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  4. CEP78 Antibody

CEP78 Antibody

  • 中文名稱：
    CEP78兔多克隆抗體
  • 貨號：
    CSB-PA001588
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using CEP78 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CEP78
  • 別名：
    CEP78 antibody; C9orf81 antibody; Centrosomal protein of 78 kDa antibody; Cep78 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CEP78.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis.
  • 基因功能參考文獻：
    1. Our results provide evidence that CEP78 is a novel disease-causing gene for Usher syndrome, demonstrating an additional link between ciliopathy and Usher protein network in photoreceptor cells and inner ear hair cells. PMID: 27627988
    2. we identify Cep78 as a new player that regulates centrosome homeostasis by inhibiting the final step of the enzymatic reaction catalyzed by EDD-DYRK2-DDB1(Vpr)(BP). PMID: 28242748
    3. the interaction between Cep78 and the N-terminal catalytic domain of Plk4 is a new and important element in the centrosome overduplication process. PMID: 27246242
    4. data strongly suggest that mutations in CEP78 cause a previously undescribed clinical entity of a ciliary nature characterized by blindness and deafness but clearly distinct from Usher syndrome, a condition for which visual impairment is due to retinitis pigmentosa PMID: 27588451
    5. truncating mutations in CEP78 result in a phenotype involving both the visual and auditory systems but different from typical Usher syndrome PMID: 27588452
    6. CEP78 functions as a tumor suppressor in colorectal cancer and low CEP78 expression leads to shorter survival in colorectal cancer patients. PMID: 27357513

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  • 相關疾病：
    Cone-rod dystrophy and hearing loss (CRDHL)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    CEP78 family
  • 組織特異性：
    Widely expressed. Expressed in different retinal cell types with higher expression in cone compared to rod cells (at protein level).
  • 數據庫鏈接：

    HGNC: 25740

    OMIM: 617110

    KEGG: hsa:84131

    STRING: 9606.ENSP00000365782

    UniGene: Hs.187621



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