CEP72 Antibody
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中文名稱：CEP72兔多克隆抗體
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貨號：CSB-PA889176DSR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: CEP72 antibody at 3.37µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 72, 22 kDa
Observed band size: 72 kDa -
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA889176DSR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CEP72 Polyclonal antibody
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Uniprot No.：
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基因名：CEP72
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別名：Centrosomal protein 72kDa antibody; Centrosomal protein of 72 kDa antibody; Cep72 antibody; CEP72_HUMAN antibody; FLJ10565 antibody; MGC5307 antibody; RGD1566336 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Centrosomal protein of 72 kDa protein (200-460AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2.
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基因功能參考文獻：
- CEP72-ROS1 is a novel ROS1 fusion variant in non-small cell lung cancer (NSCLC) discovered by next-generation sequencing and could be included in ROS1 detection assay, such as reverse transcription PCR. PMID: 29517860
- CEP72 represents a putative oncogene in colorectal cancer that might negatively regulate the mitotic function of BRCA1 to ensure chromosomal stability PMID: 26300001
- The CEP72 polymorphism can identify adults at increased risk of vincristine-induced peripheral neuropathy PMID: 27618250
- aim of this study was to determine whether the CEP72 rs924607 TT genotype is a useful marker of vincristine neuropathy during induction therapy among Spanish children with B-ALL treated on the LAL-SHOP protocols PMID: 26618658
- In this study an inherited polymorphism in the promoter region of CEP72 was associated with increased risk and severity of vincristine-related peripheral neuropathy. PMID: 25710658
- Findings show that Cep72 is the key protein essential for maintaining microtubule-organizing activity and structural integrity of the centrosome. PMID: 19536135
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亞細胞定位：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.
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蛋白家族：CEP72 family
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數據庫鏈接：
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