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  4. CEP70 Antibody

CEP70 Antibody

  • 中文名稱：
    CEP70兔多克隆抗體
  • 貨號：
    CSB-PA005247GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CEP70
  • 別名：
    BITE antibody; Centrosomal protein of 70 kDa antibody; Cep70 antibody; CEP70_HUMAN antibody; p10 binding protein antibody; p10-binding protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CEP70
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
  • 基因功能參考文獻：
    1. Cep70 interacts with tubulin, and promotes the ability of paclitaxel to stimulate microtubule assembly. These data demonstrate that Cep70 mediates paclitaxel sensitivity in breast cancer. PMID: 28632150
    2. these results demonstrate a critical role for Cep70 in the development and progression of breast cancer. PMID: 28063737
    3. Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization PMID: 26893288
    4. findings suggest that Cep70 promotes microtubule stability by interaction with HDAC6 and regulation of tubulin acetylation PMID: 26112604
    5. data showed that Cep70 increased the microtubule length without affecting the microtubule number in the purified system; results demonstrate that Cep70 could directly regulate microtubule assembly by promoting microtubule elongation instead of microtubule nucleation PMID: 22427462
    6. These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly. PMID: 21795687

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.
  • 數據庫鏈接：

    HGNC: 29972

    OMIM: 614310

    KEGG: hsa:80321

    STRING: 9606.ENSP00000264982

    UniGene: Hs.531962



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