在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CEP63 Antibody

CEP63 Antibody

  • 中文名稱：
    CEP63兔多克隆抗體
  • 貨號：
    CSB-PA005245GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CEP63
  • 別名：
    CEP63Centrosomal protein of 63 kDa antibody; Cep63 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CEP63
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.
  • 基因功能參考文獻：
    1. CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated. PMID: 26400686
    2. centrosomal Cdk1 signals were strongly diminished in cells treated with Cep63 siRNA when sc-54 was used for Cdk1 labeling PMID: 25643699
    3. both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation. PMID: 23936128
    4. Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. PMID: 23333316
    5. One new SNP (rs112926188) in CEP63O was reported. Analysis showed that rs112926188 allele substituting proline at the 61st residue position of CEP63 produced more flexibility in three-deimensional space. PMID: 22555018
    6. Findings define Cep63 as a centrosomal recruitment factor for Cdk1 that is essential for mitotic entry, providing a physical link between the centrosome and the cell-cycle machinery. PMID: 21406398
    7. CEP63 transcripts exhibited three different expression patterns, downregulation was found in about 50% of the cases analyzed and CEP63 gene transcription was associated with invasive tumors. PMID: 16410684

    顯示更多

    收起更多

  • 相關疾病：
    Seckel syndrome 6 (SCKL6)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
  • 蛋白家族：
    CEP63 family
  • 數據庫鏈接：

    HGNC: 25815

    OMIM: 614724

    KEGG: hsa:80254

    STRING: 9606.ENSP00000336524

    UniGene: Hs.443301



主站蜘蛛池模板： 无码人妻丰满熟妇啪啪7774| 无码国产精品一区二区免费模式| 少妇做爰免费视频了| 欧美性生交大片免费看| 真人做人60分钟啪啪免费看| 人成午夜大片免费视频| 国产成人无码精品久久久露脸| 国产又黄又爽又猛免费视频播放| 久久无码人妻丰满熟妇区毛片| 九个美女露脸撒尿嘘嘘视频| 国产欧洲精品自在自线官方| 久久麻豆成人精品av| 国模精品一区二区三区| 国产三区在线成人av| 国产白丝精品爽爽久久久久久蜜臀| 美国人性欧美xxxx| 两个人看的www视频免费完整版| 日韩精品久久久肉伦网站| 亚洲国产成人精品无码一区二区| 亚洲综合色视频在线观看 | 免费毛片在线看片免费丝瓜视频| 午夜一区一品日本| 久久99精品久久久久婷婷| 亚洲理论在线a中文字幕| 邪恶肉肉全彩色无遮盖| 成人欧美一区二区三区| 国产69精品久久久久777| 亚洲成本人无码薄码区| 综合亚洲桃色第一影院| 女人大荫蒂毛茸茸视频| 亚洲理论在线a中文字幕| 午夜爽爽爽男女免费观看影院| 人人妻人人玩人人澡人人爽| 日韩精品中文字幕无码专区| 日本少妇三级hd激情在线观看| av无码免费一区二区三区| 热re99久久精品国产66热| 精品国产av最大网站| 亚洲精品第一区二区三区| 色综合欧美在线视频区| 日本理论片午午伦夜理片2021|