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中文名稱：
CEP131兔多克隆抗體
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貨號：
CSB-PA000964
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規格：
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圖片：
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其他：
產品詳情
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Uniprot No.：
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基因名：
CEP131
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別名：
5 azacytidine induced 1 antibody; 5-azacytidine-induced protein 1 antibody; AZ1 antibody; Azi antibody; Azi1 antibody; AZI1_HUMAN antibody; Centrosomal protein 131 kDa antibody; Centrosomal protein of 131 kDa antibody; Cep131 antibody; KIAA1118 antibody; OTTMUSP00000004498 antibody; Pre-acrosome localization protein 1 antibody; RP23 37J21.1 antibody
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宿主：
Rabbit
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反應種屬：
Human
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免疫原：
Synthesized peptide derived from the Internal region of Human AZI1.
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免疫原種屬：
Homo sapiens (Human)
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標記方式：
Non-conjugated
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抗體亞型：
IgG
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純化方式：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：
It differs from different batches. Please contact us to confirm it.
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保存緩沖液：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：
Liquid
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應用范圍：
WB, IHC, ELISA
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推薦稀釋比：
| Application |
Recommended Dilution |
| WB |
1:500-1:2000 |
| IHC |
1:100-1:300 |
| ELISA |
1:40000 |
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Protocols：
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儲存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點詳情
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功能：
Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells. Involved in centriole duplication. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. Essential for maintaining proper centriolar satellite integrity.
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基因功能參考文獻：
- CEP131 serves as a potential prognostic biomarker in HCC PMID: 28694105
- CEP131 is the key regulatory target of MK2 and 14-3-3 in centriolar satellite remodeling. PMID: 26616734
- These data therefore highlight the importance of human Cep131 for maintaining genomic integrity PMID: 22797915
- Analysis of the data suggested that SP1 is a pivotal transcription factor for the regulation of CEP131 expression, consequently leading the control of centrosome functions. PMID: 23137637
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亞細胞定位：
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle, secretory vesicle, acrosome.
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蛋白家族：
CEP131 family
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數據庫鏈接：
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