在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CEACAM6 Antibody

  • 中文名稱:
    CEACAM6兔多克隆抗體
  • 貨號(hào):
    CSB-PA999004
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA999004(CEACAM6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA999004(CEACAM6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Carcinoembryonic antigen related cell adhesion molecule 6 antibody; Carcinoembryonic antigen related cell adhesion molecule 6 (non specific cross reacting antigen) antibody; Carcinoembryonic antigen-related cell adhesion molecule 6 antibody; CD 66c antibody; CD66c antibody; CD66c antigen antibody; CEA LIKE PROTEIN antibody; CEACAM 6 antibody; CEACAM6 antibody; CEAL antibody; CEAM6_HUMAN antibody; MGC93832 antibody; NCA antibody; Non specific cross reacting antigen antibody; Non-specific crossreacting antigen antibody; Normal cross reacting antigen antibody; Normal cross-reacting antigen antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human CEACAM6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion. Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells.
  • 基因功能參考文獻(xiàn):
    1. CEACAM6 promoted oral squamous cell carcinoma cell invasion, migration, cytoskeletal rearrangement, and metastasis via interaction with EGFR and enhancing it activation. PMID: 28892050
    2. Studies provide evidence that dysregulated overexpression of CEACAM6 plays a role in several of the hallmarks of cancer, including uncontrolled proliferation, anoikis resistance, immune evasion, invasion and metastasis. [review] PMID: 29110374
    3. Helicobacter pylori HopQ binds the amino-terminal IgV-like domain of human CEACAM1, CEACAM3, CEACAM5 or CEACAM6 proteins, thereby enabling translocation of the major pathogenicity factor CagA into host cells. PMID: 27748756
    4. Here, the authors identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of Helicobacter pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. PMID: 27748768
    5. CD66c (KOR-SA3544) antigen expression of leukemic blasts in pediatric acute myeloid leukemia with TLS/FUS-ERG fusion transcript PMID: 28766906
    6. Data suggest that the expression of these TSPAN8, LGALS4, COL1A2 and CEACAM6 in the whole blood may be useful in the detection of colorectal cancer (CRC). PMID: 26993598
    7. expression is increased in severe asthma and primarily associated with airway epithelial cells and tissue neutrophils PMID: 28275137
    8. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8 PMID: 27579896
    9. In enterocytic C2BBe1 cells, Candida albicans caused a transient tyrosine phosphorylation of CEACAM1 and induced higher expression of membrane-bound CEACAM1 and soluble CEACAM6. PMID: 28292985
    10. Monoclonal Antibody 1B5A5 Against CEACAM6 PMID: 27328063
    11. western blot analysis results indicated that the 1B5A5 epitope is located within an amino-terminal domain of CEACAM6. These results raised the possibility that our approach could lead to discovery of novel biomarkers for the early stage of cancers in a relatively short period of time. PMID: 27172290
    12. show the upregulation of the tumor-associated antigens CEACAM5/6 by trans-signaling of the pro-inflammatory cytokine IL-6 PMID: 26673628
    13. Biliary CEACAM6 can identify patients with extrahepatic cholangiocarcinoma with a high degree of sensitivity and should be investigated further as a potential screening tool. PMID: 26974538
    14. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
    15. CEACAM6 protein and mRNA were increased ~4-fold in lungs from infants with chronic lung disease as compared with controls. PMID: 26374831
    16. vaccination with recombinant attenuated Salmonella harboring the CEACAM6 and 4-1BBL gene efficiently increased the number of CD3+CD8+ TIL and NK cells, decreased the number of FOXP3 cells and inhibited the development of DMH-induced colorectal cancer PMID: 25872647
    17. CEACAM6 increased the levels of phosphorylated AKT, which is involved in the progression of a variety of human tumors. PMID: 25398131
    18. Data show that carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) and forkhead box P3 (FOXP3) are associated with the malignant degree of pancreatic cancer. PMID: 26271985
    19. Data indicate that carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes angiogenesis in gastric cancer via focal adhesion kinase FAK signaling. PMID: 25703140
    20. Results show that pancreatic cancer patients with CEACAM 1, 5 and 6 expression showed a significantly shortened overall survival and elevated serum values are correlated with distant metastasis suggesting a role in epithelial-mesenchymal transition. PMID: 25409014
    21. CEACAM6 may be a valuable biomarker screening for gastric tumor and novel predictor for patients in advanced stages of gastric cancer PMID: 25299082
    22. results suggested that CEACAM6 functions as an oncoprotein in gastric cancer and may be an important metastatic biomarker and therapeutic target PMID: 24492534
    23. CEACAM6 expression was expressed in different molecular subtypes of breast cancer. Among different subtypes, the highest expression was found with HER2 positive cancers. PMID: 24186057
    24. High carcinoembryonic cell adhesion molecule 6 expression is associated with malignant biliary stenoses. PMID: 23806607
    25. our findings identified CEACAM6, which is regulated by miR-29a/b/c, as an important positive regulator of EMT in pancreatic cancer PMID: 23857344
    26. CD66c expression appears useful only as a predictor of the Ph in adult patients (not in pediatric cases). PMID: 24014076
    27. Data indicate that CD66c is frequently expressed in CRLF2-positive as well as hypodiploid cases. PMID: 24231528
    28. these findings show that PDEF-CEACAM6 is a highly active oncogenic axis in breast cancer PMID: 23592399
    29. CEACAM-6 plays an important role in the regulation of CD8+ T-cell responses against multiple myeloma. PMID: 23603913
    30. CEACAM6 is significantly upregulated in colon cancer tissues and is closely associated with poor prognosis. PMID: 22975528
    31. The expression of CD66c was significantly higher in colorectal cancer specimens than in normal colon. PMID: 23027178
    32. CEACAM6 is focally overexpressed in a large fraction of human HNSCCs in situ. over-expression of CEACAM6 increases tumour growth and tumour initiating activity by suppressing PI3K/AKT-dependent apoptosis of HNSCC in a xenotransplant model of HNSCC. PMID: 23021083
    33. High CEACAM6 expresssion is associated with inflammatory bowel disease. PMID: 21994005
    34. a novel role for NA in enhancing host cell survival by activating the Src/Akt signaling axis via an interaction with carcinoembryonic antigen-related cell adhesion molecule 6/cluster of differentiation 66c (C6). PMID: 22396546
    35. The authors show that the expression of CEACAM1 and CEACAM6 potentiate CEACAM3-dependent responses of neutrophils, exposing a cooperative role for this family of proteins during neisserial infection of neutrophils. PMID: 22064717
    36. CEACAM6 is expressed by alveolar and airway epithelial cells of human lung and is secreted into lung-lining fluid, where fully glycosylated protein binds to surfactant. PMID: 22037359
    37. Despite its important role in bacterial attachment in ileal CD, no role was detected for CEACAM6 variants in IBD susceptibility or regarding an ileal CD phenotype PMID: 21559399
    38. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
    39. High serum CEACAM6 is associated with gastric cancer. PMID: 21618249
    40. CEACAM6 and a regulatory element near the 3' end of CEACAM3 are associated with cystic fibrosis disease severity and intrapair discordance PMID: 20047061
    41. Positivity for both leukemia-associated antigens CD66c and CD25 in combination can predict the presence of BCR/ABL rearrangement in pre-B cell acute lymphoblastic leukemia PMID: 20063526
    42. Overexpression of CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation PMID: 11896570
    43. CEACAM6 subdomains involved in intercellular adhesion activity and subdomains involved in inhibition of cell differentation are identified and their respective activities are independently blocked. PMID: 12571231
    44. CEACAM6 gene silencing reversed the acquired anoikis resistance of tumor cell lines and inhibited in vivo metastatic ability PMID: 14724575
    45. overexpression among human malignancies, immunological targeting of this tumor antigen may have therapeutic applicability PMID: 15081416
    46. the results show that recognition of CEA and CEACAM6, but not CEACAM1, is accompanied by tight attachment to bacteria of cell surface microvilli-like extensions PMID: 15130118
    47. CEACAM6 is an important determinant of pancreatic adenocarcinoma malignant cellular behavior PMID: 15208677
    48. Levels of CEACAM6 expression can modulate pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner PMID: 15316565
    49. CD66c is regulated in a manner distinct from other myeloid antigens in childhood lymphoblastic leukemia PMID: 15826304
    50. Data show that variants of Neisseria gonorrhoeae that bind to human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) 1 and 6 failed to induce detachment and, instead, promoted enhanced host cell adhesion to the ECM. PMID: 16115956

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface.
  • 蛋白家族:
    Immunoglobulin superfamily, CEA family
  • 組織特異性:
    Expressed in neutrophils. Expressed in columnar epithelial and goblet cells of the colon. Expressed in numerous tumor cell lines (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1818

    OMIM: 163980

    KEGG: hsa:4680

    STRING: 9606.ENSP00000199764

    UniGene: Hs.466814



主站蜘蛛池模板: 亚洲国产精品成人精品无码区| 99久热在线精品996热是什么| 日本护士毛茸茸| 久人人爽人人爽人人片av| 色资源av中文无码先锋| 午夜在线看的免费网站 | 国产色情又大又粗又黄的电影| 国产高清在线精品一区下载| 狠狠综合久久综合88亚洲| 精品深夜av无码一区二区| 岛国片人妻三上悠亚| 国产午夜精品一区二区三区老| 一本一本久久a久久综合精品| 曰批全过程免费视频在线观看无码| 久久久久波多野结衣高潮| 日本久久久久久久做爰片日本| 精品午夜福利在线视在亚洲| 琪琪午夜理论片福利在线观看| 国模gogo无码人体啪啪| 国产剧情国产精品一区| 国产欧美另类久久久精品图片| 欧美成人精品午夜免费影视| 2020精品国产a不卡片| 伦埋琪琪电影院久久| 亚欧免费无码aⅴ在线观看蜜桃| 成人麻豆亚洲综合无码精品| 色婷婷六月亚洲综合香蕉| 特大巨黑吊xxxx高潮| 国产真实乱人偷精品视频| 亚洲欧洲自拍拍偷综合| 亚洲人成线无码7777| 亚洲国产成人精品女人久久久 | 日本熟人妻中文字幕在线| 国产成人精品一区二区三区视频 | 国产麻豆剧果冻传媒一区 | 少妇富婆高级按摩出水高潮 | 精品国产成人网站一区在线| 麻豆一区二区三区蜜桃免费| 2017亚洲天堂最新地址| 97精品免费公开在线视频| 亚洲老妈激情一区二区三区|