在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDYL Antibody

  • 中文名稱:
    CDYL兔多克隆抗體
  • 貨號:
    CSB-PA896685LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA896685LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: CDYL antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 67, 61, 35, 46 kDa
      Observed band size: 67 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CDYL Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CDYL
  • 別名:
    CDY-like antibody; CDY-like autosomal antibody; Cdyl antibody; CDYL: chromodomain protein Y-like antibody; CDYL1 antibody; CDYL1_HUMAN antibody; chromodomain protein Y chromosome-like 6 antibody; Chromodomain protein Y like antibody; Chromodomain Y-like protein antibody; DKFZP586C1622 antibody; MGC131936 antibody; OTTHUMP00000015984 antibody; OTTHUMP00000211185 antibody; OTTHUMP00000211186 antibody; OTTHUMP00000211189 antibody; testis-specific chromodomain Y-like protein antibody; Weakly similar to enoyl-CoA hydratase [H.sapiens] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Chromodomain Y-like protein (8-260AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CDYL Antibody (CSB-PA896685LA01HU),的標記方式是Non-conjugated。對于CDYL Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA896685LB01HU CDYL Antibody, HRP conjugated ELISA
    FITC CSB-PA896685LC01HU CDYL Antibody, FITC conjugated
    Biotin CSB-PA896685LD01HU CDYL Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:3000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2. Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs. Required for neuronal migration during brain development by repressing expression of RHOA. By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis. In addition to acting as a chromatin reader, acts as a hydro-lyase. Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation. Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids. By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression.; Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain.; Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain. Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.
  • 基因功能參考文獻:
    1. CDYL plays an important role in the maintenance of repressive histone marks during replication, providing a mechanism for understanding of the epigenetic inheritance and memory. PMID: 28402439
    2. CDYL negatively regulates histone crotonylation by acting as a crotonyl-CoA hydratase to convert crotonyl-CoA to beta-hydroxybutyryl-CoA and suggest role in spermatogenesis. PMID: 28803779
    3. The epigenetic regulators CDYL and EZH2 to dendrite morphogenesis and might shed new light on our understanding of the regulation of the neurodevelopment. PMID: 24671995
    4. These findings suggest that h-CDYLb and G9a are cooperatively involved in hepatocellular carcinomas PMID: 23629948
    5. CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin PMID: 22009739
    6. Results imply that multimeric binding to H3K9me3 by CDYL1b homomeric complexes is essential for efficient chromatin targeting. PMID: 19808672
    7. Chromodomain on Y-like (CDYL) is identified as a REST corepressor that physically bridges REST and the histone methylase G9a to repress transcription. PMID: 19061646

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 2]: Nucleus. Chromosome.
  • 組織特異性:
    Expressed in the hippocampus with reduced expression in epileptic tissue compared to normal adjacent tissue (at protein level). Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2: Most abundantly expressed isoform.
  • 數據庫鏈接:

    HGNC: 1811

    OMIM: 603778

    KEGG: hsa:9425

    STRING: 9606.ENSP00000380718

    UniGene: Hs.269092



主站蜘蛛池模板: 熟妇的奶头又大又长奶水视频| 一卡二卡三卡视频| 无码人妻丰满熟妇区免费 | 久久国产人妻一区二区| 少妇无码太爽了不卡视频在线看| 欧美孕妇变态重口另类| 国产96色在线 | 国| 亚洲欧美v国产一区二区| 97夜夜澡人人爽人人模人人喊| 无码国内精品久久人妻| 日韩成人无码中文字幕| 无码精品人妻一区二区三区人妻斩| 国产在线精品一区二区在线看| 亚洲欧洲综合有码无码| 亚洲人成欧美中文字幕| 美女视频黄是免费| 国产精品高潮呻吟av久久4虎| 国产精品一国产精品一k频道 | 免费国产线观看免费观看| 国产精品无套呻吟在线| 影音先锋女人aa鲁色资源| 国产精品美脚玉足脚交欧美| 欧亚乱熟女一区二区三区在线| 国产欧美日韩久久久久| 久久久日韩精品一区二区三区| 欧美老妇大p毛茸茸| 欧美综合自拍亚洲综合图片区| 激情综合婷婷丁香五月情| 久久久久亚洲精品成人网| 美丽的熟妇中文字幕| 国产无套内射普通话对白| 毛片完整版的免费观看| 最美女人体内射精一区二区| 亚洲 a v无 码免 费 成 人 a v | 青青草原精品资源站久久| 国产精品一久久香蕉国产线看观看| 日本十八禁视频无遮挡| 免费无码av片在线观看潮喷| 成人网站国产在线视频内射视频| 亚洲电影在线观看| 国产aⅴ激情无码久久久无码|