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CDSN Antibody

  • 中文名稱:
    CDSN兔多克隆抗體
  • 貨號:
    CSB-PA005124LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Mouse liver tissue, Mouse kidney tissue, MCF-7 whole cell lysate
      All lanes: CDSN antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 52 kDa
      Observed band size: 52, 36 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA005124LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CDSN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CDSN
  • 別名:
    AI747712 antibody; CDSN antibody; CDSN_HUMAN antibody; Corneodesmosin antibody; D6S586E antibody; DADB-141O4.5 antibody; Differentiated keratinocyte S protein antibody; HTSS antibody; S antibody; S protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Corneodesmosin protein (40-229AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CDSN Antibody (CSB-PA005124LA01HU),的標記方式是Non-conjugated。對于CDSN Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA005124LB01HU CDSN Antibody, HRP conjugated ELISA
    FITC CSB-PA005124LC01HU CDSN Antibody, FITC conjugated
    Biotin CSB-PA005124LD01HU CDSN Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Important for the epidermal barrier integrity.
  • 基因功能參考文獻:
    1. results show, for the first time, the male-only associations of the PSORS1C3 gene with psoriasis risk and of the PSORS1C1/CDSN gene with severity of disease. However, the age dependent associations need to be validated in larger sample sizes as well as in other populations. PMID: 29589160
    2. We found that a burden of low-frequency coding variants in N4BP2, CDSN, PRTG, and AHRR were associated with increased risk of Nonsyndromic cleft lip with or without cleft palate (NSCL/P) . Low-frequency variants in other genes were associated with decreased risk of NSCL/P. These results demonstrate that low-frequency variants contribute to the genetic etiology of NSCL/P PMID: 28425186
    3. Investigated potential direct protein-protein interactions between six late cornified envelope (LCE) proteins and two corneodesmosin sequence variants. Partial colocalization of LCE2 and CDSN was observed in normal and psoriasis skin. PMID: 25078048
    4. we report a patient with PSD caused by a novel homozygous large deletion in the 6p21.3 region encompassing the CDSN gene, which abrogates CDSN expression PMID: 24116970
    5. Case Report: homozygous deletion of CDSN was considered to be responsible for generalized peeling skin disease. PMID: 24794518
    6. PSORS1C1/CDSN gene may play a pathogenic role in ankylosing spondylitis PMID: 24210685
    7. A nonsense mutation (C717G) in cDNA sequence of the CDSN gene was identified in all three patients of the family. PMID: 22875505
    8. CDSN -619C/T polymorphism may not be associated with susceptibility to psoriasis. PMID: 22033905
    9. CDSN plays a vital role in the structural and functional integrity of the epidermis and the hair follicle integrity by preventing the rupture of corneodesmosome. PMID: 21628128
    10. identified mRNA transcripts from three genes CDSN, LOR and KRT9, showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification PMID: 21221983
    11. Study of consangunity in a large family points to a homozygous nonesense mutation of the gene coding for corneodesmosin. PMID: 21134591
    12. The distribution of corneodesmosin on the surface of the stratum corneum was mapped at the nanoscale using atomic force microscopy. PMID: 21182673
    13. Data identifies hypotrichosis simplex of the scalp as a human amyloidosis related to the aggregation of natively unfolded (mut)CDSN polypeptides into amyloid fibrils. PMID: 20448140
    14. Lack of corneodesmosin causes an epidermal barrier defect supposed to account for the predisposition to atopic diseases. PMID: 20691404
    15. identified nonsense mutations in the gene CDSN (encoding corneodesmosin) in three families suffering from hypotrichosis simplex of the scalp PMID: 12754508
    16. non-glycosylated CDSN is able to spontaneously form large homo-oligomers in vitro and that the N-terminal glycine loop domain is necessary for the formation of these macromolecular complexes. PMID: 15086562
    17. Association analyses show that haplotypes bearing CDSN*971T maps to a RNA stability motif and confers psoriasis susceptibility in a wide range of ethnic groups. PMID: 15333584
    18. phenotype of Netherton syndrome is a consequence of desmosomal fragility associated with premature proteolysis of corneodesmosin PMID: 15466487

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  • 相關疾病:
    Hypotrichosis 2 (HYPT2); Peeling skin syndrome 1 (PSS1)
  • 亞細胞定位:
    Secreted. Note=Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
  • 組織特異性:
    Exclusively expressed in skin.
  • 數據庫鏈接:

    HGNC: 1802

    OMIM: 146520

    KEGG: hsa:1041

    STRING: 9606.ENSP00000365465

    UniGene: Hs.310958



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