在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDSN Antibody

  • 中文名稱:
    CDSN兔多克隆抗體
  • 貨號:
    CSB-PA005124LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Mouse liver tissue, Mouse kidney tissue, MCF-7 whole cell lysate
      All lanes: CDSN antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 52 kDa
      Observed band size: 52, 36 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA005124LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CDSN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CDSN
  • 別名:
    AI747712 antibody; CDSN antibody; CDSN_HUMAN antibody; Corneodesmosin antibody; D6S586E antibody; DADB-141O4.5 antibody; Differentiated keratinocyte S protein antibody; HTSS antibody; S antibody; S protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Corneodesmosin protein (40-229AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CDSN Antibody (CSB-PA005124LA01HU),的標記方式是Non-conjugated。對于CDSN Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA005124LB01HU CDSN Antibody, HRP conjugated ELISA
    FITC CSB-PA005124LC01HU CDSN Antibody, FITC conjugated
    Biotin CSB-PA005124LD01HU CDSN Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Important for the epidermal barrier integrity.
  • 基因功能參考文獻:
    1. results show, for the first time, the male-only associations of the PSORS1C3 gene with psoriasis risk and of the PSORS1C1/CDSN gene with severity of disease. However, the age dependent associations need to be validated in larger sample sizes as well as in other populations. PMID: 29589160
    2. We found that a burden of low-frequency coding variants in N4BP2, CDSN, PRTG, and AHRR were associated with increased risk of Nonsyndromic cleft lip with or without cleft palate (NSCL/P) . Low-frequency variants in other genes were associated with decreased risk of NSCL/P. These results demonstrate that low-frequency variants contribute to the genetic etiology of NSCL/P PMID: 28425186
    3. Investigated potential direct protein-protein interactions between six late cornified envelope (LCE) proteins and two corneodesmosin sequence variants. Partial colocalization of LCE2 and CDSN was observed in normal and psoriasis skin. PMID: 25078048
    4. we report a patient with PSD caused by a novel homozygous large deletion in the 6p21.3 region encompassing the CDSN gene, which abrogates CDSN expression PMID: 24116970
    5. Case Report: homozygous deletion of CDSN was considered to be responsible for generalized peeling skin disease. PMID: 24794518
    6. PSORS1C1/CDSN gene may play a pathogenic role in ankylosing spondylitis PMID: 24210685
    7. A nonsense mutation (C717G) in cDNA sequence of the CDSN gene was identified in all three patients of the family. PMID: 22875505
    8. CDSN -619C/T polymorphism may not be associated with susceptibility to psoriasis. PMID: 22033905
    9. CDSN plays a vital role in the structural and functional integrity of the epidermis and the hair follicle integrity by preventing the rupture of corneodesmosome. PMID: 21628128
    10. identified mRNA transcripts from three genes CDSN, LOR and KRT9, showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification PMID: 21221983
    11. Study of consangunity in a large family points to a homozygous nonesense mutation of the gene coding for corneodesmosin. PMID: 21134591
    12. The distribution of corneodesmosin on the surface of the stratum corneum was mapped at the nanoscale using atomic force microscopy. PMID: 21182673
    13. Data identifies hypotrichosis simplex of the scalp as a human amyloidosis related to the aggregation of natively unfolded (mut)CDSN polypeptides into amyloid fibrils. PMID: 20448140
    14. Lack of corneodesmosin causes an epidermal barrier defect supposed to account for the predisposition to atopic diseases. PMID: 20691404
    15. identified nonsense mutations in the gene CDSN (encoding corneodesmosin) in three families suffering from hypotrichosis simplex of the scalp PMID: 12754508
    16. non-glycosylated CDSN is able to spontaneously form large homo-oligomers in vitro and that the N-terminal glycine loop domain is necessary for the formation of these macromolecular complexes. PMID: 15086562
    17. Association analyses show that haplotypes bearing CDSN*971T maps to a RNA stability motif and confers psoriasis susceptibility in a wide range of ethnic groups. PMID: 15333584
    18. phenotype of Netherton syndrome is a consequence of desmosomal fragility associated with premature proteolysis of corneodesmosin PMID: 15466487

    顯示更多

    收起更多

  • 相關疾病:
    Hypotrichosis 2 (HYPT2); Peeling skin syndrome 1 (PSS1)
  • 亞細胞定位:
    Secreted. Note=Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
  • 組織特異性:
    Exclusively expressed in skin.
  • 數據庫鏈接:

    HGNC: 1802

    OMIM: 146520

    KEGG: hsa:1041

    STRING: 9606.ENSP00000365465

    UniGene: Hs.310958



主站蜘蛛池模板: 色妺妺免费影院| 久久综合给合久久狠狠狠97色| 精品福利一区二区三区免费视频| 中文字幕精品久久久久人妻红杏ⅰ| 日韩爆乳一区二区无码| 亚洲国产精品无码中文字| 极品老师腿张开粉嫩小泬| 国产又黄又爽又猛免费视频播放| 18禁无码永久免费无限制网站 | 永久免费观看美女裸体视频的网站| 中国免费看的片| 无码人妻精品一区二区三区在线| 久久国产精品无码hdav| 非洲黑人性xxxx精品| 国产精品无码一区二区在线看| 毛片无码国产| 人妻无码中文字幕免费视频蜜桃| 国产乱人伦偷精品视频下| 午夜伦费影视在线观看| 欧美老熟妇乱子伦视频| 国产乱子经典视频在线观看| 国产在不卡免费一区二区三| 亚洲综合色无码| 特级毛片爽www免费版| 色妺妺av爽爽影院| 激情国产av做激情国产爱| 亚洲国产精品综合久久20| 亚洲精品久久久久中文第一幕| 欧美韩中文精品有码视频在线| 伊人久久大香线蕉综合影院首页| 久久av无码精品人妻出轨| 亚洲精品亚洲人成在线| 神马午夜福利不卡片在线| 国产成人无码短视频| 狠狠色综合7777久夜色撩人ⅰ | 女学生14毛片视频片二毛| 国产av天堂亚洲国产av天堂| 国产精品久久..4399| 香蕉蕉亚亚洲aav综合| 国产大量精品视频网站| 水蜜桃色314在线观看|