在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CDK7 Antibody

CDK7 Antibody

  • 中文名稱：
    CDK7兔多克隆抗體
  • 貨號(hào)：
    CSB-PA005075LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA005075LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA005075LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CDK7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    39 kDa protein kinase antibody; CAK antibody; CAK1 antibody; Cdk activating kinase antibody; CDK-activating kinase 1 antibody; CDK-activating kinase antibody; cdk7 antibody; CDK7_HUMAN antibody; CDKN7 antibody; Cell division protein kinase 7 antibody; Cyclin dependent kinase 7 antibody; cyclin-dependent kinase 7 (MO15 homolog; Xenopus laevis; cdk-activating kinase) antibody; Cyclin-dependent kinase 7 antibody; HCAK antibody; Homolog of Xenopus MO15 Cdk activating kinase antibody; Kinase subunit of CAK antibody; MO15 antibody; MO15; Xenopus; homolog of antibody; P39 Mo15 antibody; p39MO15 antibody; Serine threonine kinase Stk1 antibody; Serine/threonine protein kinase 1 antibody; Serine/threonine protein kinase MO15 antibody; STK1 antibody; TFIIH basal transcription factor complex kinase subunit antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cyclin-dependent kinase 7 protein (212-341AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CDK7 Antibody (CSB-PA005075LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于CDK7 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA005075LB01HU CDK7 Antibody, HRP conjugated ELISA
    FITC CSB-PA005075LC01HU CDK7 Antibody, FITC conjugated
    Biotin CSB-PA005075LD01HU CDK7 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
  • 基因功能參考文獻(xiàn)：
    1. Study demonstrate that CDK7 activity is necessary to maintain the transcriptional program induced by STAT proteins that are activated both aberrantly by mutation and by extracellular cues in T-cell lymphomas. PMID: 28134252
    2. these results implicate a CDK7-dependent "CTD code" that regulates chromatin marks in addition to RNA processing and pol II pausing. PMID: 28768201
    3. Our studies have demonstrated the essential role of endogenous PRL and CDK7 in the upregulation of PRLR by E2 and provide insights for therapeutic approaches that will mitigate the transcription/expression of PRLR and its participation in breast cancer progression fueled by E2 and PRL via their cognate receptors. PMID: 28423697
    4. MYC promotes mRNA cap methylation and protein production of Wnt/beta-catenin signaling transcripts through recruitment of cyclin-dependent kinase 7 (CDK7) and consequently RNMT to gene promoters. PMID: 27899423
    5. High expression of MMP14 and CDK7 was independent prognostic factors for overall survival in patients with gastric cancer. PMID: 27562173
    6. Taken together, these findings elucidated a novel mechanism of prostate cancer progression. Thus, SNHG1 might serve as a potential target for prostate cancer therapies. PMID: 28400279
    7. Data indicate that cyclin dependent kinase 7 (CDK7) is overexpressed in gastric cancer cell lines and tissues. PMID: 27155449
    8. Cdk7 broadly influences transcription and capping. PMID: 26257281
    9. Study shows that triple-negative but not hormone receptor-positive breast cancer cells are exceptionally dependent on CDK7, a transcriptional cyclin-dependent kinase. PMID: 26406377
    10. Data suggest a quantitative contribution of CDK7 to mRNA synthesis, which is critical for cellular homeostasis. PMID: 25047832
    11. Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration PMID: 23393140
    12. three CTD kinases, CDK7, CDK9, and BRD4, engage in cross-talk, modulating their subsequent C-terminal domain phosphorylation, and also phosphorylate TAF7 PMID: 23027873
    13. Cdk7 thus acts through TFIIE and DSIF to establish, and through P-TEFb to relieve, barriers to elongation: incoherent feedforward that might create a window to recruit RNA-processing machinery. PMID: 23064645
    14. glioma cells may be proliferating through a novel PI (3)-kinase-/PKC-iota/Cdk7/cdk2-mediated pathway. PMID: 22021906
    15. Our findings suggest that the CDK7 TT genotype and the combined genetic polymorphisms of CDK7 and ESR1P325P are associated with breast cancer in Korean women. PMID: 19941161
    16. determined the crystal structure of human CDK7 in complex with ATP at 3 A resolution PMID: 15530371
    17. Cdk7 accomplishes dual functions in cell-cycle control and transcription not through promiscuity but through distinct, stringent modes of substrate recognition. PMID: 16327805
    18. Different modes of CDK activation by Cdk7 at two distinct execution points in the cell cycle. PMID: 17386261
    19. Data revealed that SF1 and CDK7 reside in the same complex and CDK inhibitor roscovitine blocked phosphorylation of SF1, and an inactive form of CDK7 repressed the phosphorylation level and the transactivation capacity of SF1. PMID: 17901130
    20. A role of Cdk7 in regulating elongation is further suggested by enhanced histone H4 acetylation and diminished histone H4 trimethylation on lysine 36-two marks of elongation-within genes when the kinase was inhibited. PMID: 19667075

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1778

    OMIM: 601955

    KEGG: hsa:1022

    STRING: 9606.ENSP00000256443

    UniGene: Hs.184298



主站蜘蛛池模板： 亚洲跨种族黑人xxxxx| 玩弄了裸睡少妇人妻野战| 无码av在线一本无码| 久久97超碰色中文字幕总站| 性色做爰片在线观看ww| 精品久久久久久综合日本| 国内无遮挡18禁无码网站免费| 亚洲男男无套gv大学生| 精人妻无码一区二区三区| 又黄又爽吃奶视频在线观看| 国产成人精品自在线导航| 丰满的少妇被猛烈进入白浆| 99久久人妻无码精品系列蜜桃 | 亚洲学生妹高清av| 国产白袜脚足j棉袜在线观看| 国产成人av大片大片在线播放 | 国产在线精品一区二区三区| 无码av免费精品一区二区三区| 国产边摸边吃奶边做爽视频| 又黄又湿啪啪响18禁| 放荡的少妇2欧美版| 4438xx亚洲最大五色丁香| 亚洲国产成人精品福利| 亚洲乱码中文字幕综合234 | 色狠狠色狠狠综合天天| 人妻少妇heyzo无码专区| 亚在线第一国产州精品99| 国产亚洲精品综合一区| 亚洲精品久久久久久久久久吃药| 国产精品狼人久久久久影院| 熟妇无码熟妇毛片| 国产又色又爽又黄又免费| 人妻有码av中文字幕久久琪| 久久久久免费看成人影片| 99久久久国产精品消防器材| 国产欧美va欧美va香蕉在线| 免费大黄网站在线观| 拍拍拍无挡免费视频| 国产日产欧产精品网站| 亚洲熟妇av乱码在线观看| 色综合久久久久综合99|