在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CDK5RAP3 Antibody

CDK5RAP3 Antibody

  • 中文名稱：
    CDK5RAP3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA842691LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, Jurkat whole cell lysate, Rat liver tissue
      All lanes: CDK5RAP3 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 57, 47, 32, 60 kDa
      Observed band size: 57 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA842691LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CDK5RAP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CDK5RAP3
  • 別名：
    C53 antibody; CDK5 activator binding protein C53 antibody; CDK5 activator-binding protein C53 antibody; CDK5 regulatory subunit associated protein 3 antibody; CDK5 regulatory subunit-associated protein 3 antibody; Cdk5rap3 antibody; CK5P3_HUMAN antibody; HSF 27 antibody; HSF27 antibody; IC53 antibody; Ischemic heart CDK5 activator binding protein C53 antibody; LXXLL/leucine zipper containing ARFbinding protein antibody; LZAP antibody; MST016 antibody; OK/SW cl.114 antibody; PP1553 antibody; Protein HSF-27 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human CDK5 regulatory subunit-associated protein 3 protein (42-292AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CDK5RAP3 Antibody (CSB-PA842691LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于CDK5RAP3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA842691LB01HU CDK5RAP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA842691LC01HU CDK5RAP3 Antibody, FITC conjugated
    Biotin CSB-PA842691LD01HU CDK5RAP3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1. Required for liver development.; (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
  • 基因功能參考文獻(xiàn)：
    1. CDK5RAP3 negatively regulates the beta-catenin signaling pathway by repressing GSK-3beta phosphorylation in gastric neoplasms. PMID: 27793695
    2. C53/LZAP protein bound indirectly to the microtubule (MT), and expression of the C53/LZAP cleavage product caused abnormal MT bundling and NE rupture. PMID: 23478299
    3. our findings provide the new evidence that overexpression of CDK5RAP3 promotes HCC metastasis via downregulation of p14(ARF). PMID: 22860085
    4. LZAP may play an important role in hepatocellular carcinoma progression PMID: 22028922
    5. our results strongly suggest that the binding of hepatitis viral pre-S2 LHBs with C53 is a novel negative regulator of the checkpoint response PMID: 21971960
    6. Data indicate that IC53 is a positive mediator for colon cancer progression, and IC53-rs2737 may serve as protection from the onset of colorectal cancer. PMID: 21394385
    7. Nuclear gamma-tubulin interacts with tumor suppressor protein C53 that is involved in regulation of DNA damage PMID: 21465471
    8. the ability of LZAP to alter p38 phosphorylation depended, at least partially, on the p38 phosphatase, Wip1 PMID: 21283629
    9. Findings reveal that CDK5RAP3 is widely overexpressed in hepatocellular carcinoma and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation. PMID: 21385901
    10. IC53 is a novel gene, mainly expressed in vascular endothelial cells and mediates cell proliferation PMID: 12054757
    11. results strongly indicate that in response to genotoxic stress, Cdk5 activator-binding protein C53(C53) serves as an important regulatory component of DNA damage checkpoint through modulating cyclin dependent kinase 1-cyclin B1 function PMID: 15790566
    12. It is suggested that LZAP can regulate ARF biochemical and biological activity; additionally, LZAP has p53-dependent cell-cycle effects that are independent of ARF. PMID: 16173922
    13. it is concluded that CDK5RAP3, CCNB2, and RAGE genes may be used as a very reliable biomarkers of lung adenocarcinoma PMID: 17549666
    14. LZAP has a role in NF-kappaB regulation and tumor suppression. PMID: 17785205
    15. CDK5 regulatory subunit associated protein 3 promotes checkpoint kinase 1 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response. PMID: 19223857
    16. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. PMID: 19541669

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    CDK5RAP3 family
  • 組織特異性：
    Ubiquitously expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18673

    OMIM: 608202

    KEGG: hsa:80279

    STRING: 9606.ENSP00000344683

    UniGene: Hs.20157



主站蜘蛛池模板： 三级国产三级在线| 永久免费无码网站在线观看个| 激情综合色综合啪啪五月丁香搜索 | 18禁美女裸体免费网站| 日日噜噜夜夜狠狠久久蜜桃| 久久香综合精品久久伊人| 野花在线无码视频在线播放| 午夜亚洲影院在线观看| 国产男女猛烈无遮挡免费视频网站 | 成人性做爰aaa片免费| 女人高潮被爽到呻吟在线观看| 中文字幕无码毛片免费看| 无码不卡中文字幕av| 国产美女视频免费观看网址| 国产曰批免费视频播放免费| 老熟女重囗味hdxx70星空| 国产92成人精品视频免费| 亚洲αⅴ无码乱码在线观看性色 | 日产电影一区二区三区| 婷婷五月综合激情中文字幕| 偷窥 亚洲 另类 图片 熟女| 亚洲中文综合网五月俺也去| 自慰无码一区二区三区| 天天色影网| 激情射精爆插热吻无码视频| 精品国产第一福利网站| 色欲国产麻豆一精品一av一免费| 高h纯肉无码视频在线观看| 亚洲高清国产av拍精品青青草原| 丰满的少妇hd高清中文字幕| 国产欧美精品区一区二区三区| 97人妻人人做人碰人人爽| 午夜福利啪啪无遮挡免费| 日日碰狠狠躁久久躁9| 99久久亚洲精品无码毛片| 福利视频在线播放| 巨熟乳波霸若妻在线播放| 久久人妻夜夜做天天爽| 强睡邻居人妻中文字幕| 亚洲综合色噜噜狠狠网站超清| 国产成人a在线观看视频|