在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDK3 Antibody

  • 中文名稱:
    CDK3兔多克隆抗體
  • 貨號:
    CSB-PA005064GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CDK3
  • 別名:
    Cdk 3 antibody; Cdk3 antibody; CDK3_HUMAN antibody; CDKN3 antibody; Cell division kinase 3 antibody; Cell division protein kinase 3 antibody; Cyclin dependent kinase 3 antibody; Cyclin-dependent kinase 3 antibody; OTTHUMP00000206828 antibody; p36 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human CDK3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
  • 基因功能參考文獻:
    1. These results suggest that miR-125a-3p can function as a novel tumor suppressor in ER(+) breast cancer by targeting CDK3, which may be a potential therapeutic approach for TamR breast cancer therapy PMID: 28939591
    2. HuR facilitated lung cancer stemness dependent on CDK3 expression. miR-873 or miR-125a-3p level was negatively correlated with HuR and CDK3 expression levels in lung cancer tissues. HuR facilitates lung cancer stemness via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis. PMID: 29344850
    3. ectopic expression of HuR promotes breast cancer cell proliferation and survival by directly binding to and stabilizing CDK3 mRNA. PMID: 28501005
    4. These results provided evidence supporting the oncogenic potential of NFAT3 and suggested that CDK3-mediated phosphorylation of NFAT3 has an important role in skin tumorigenesis. PMID: 27893713
    5. The analysis of tumor and matched normal lung tissues indicates that miR-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR-150 transfection experiments with cancer-derived cell lines reveal that miR-150-mediated CDK3 suppression directly induces growth inhibition. PMID: 28108217
    6. High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis. PMID: 26755651
    7. Data indicate that microRNA miR-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC) through inhibition of E2F2 transcription factor (E2F2), cyclin-dependent kinases CDK3 and CDK6. PMID: 26498144
    8. Mir-873 inhibits ESR1 activity and cell growth via targeting CDK3. PMID: 25531331
    9. CDK3 is associated with the progression of NPC, and may be a potential biomarker for prediction of the prognosis of patients with NPC. PMID: 24691537
    10. The Walleye dermal sarcoma virus cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 and Cdk3. PMID: 21067790
    11. A non-cdk8-associated cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently. PMID: 15084261
    12. Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1)and enhances the transactivation and transcriptional activities of ATF1. PMID: 18794154

    顯示更多

    收起更多

  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性:
    Expressed in cancer cell lines and glioblastoma tissue.
  • 數據庫鏈接:

    HGNC: 1772

    OMIM: 123828

    KEGG: hsa:1018

    STRING: 9606.ENSP00000400088

    UniGene: Hs.706766



主站蜘蛛池模板: 综合在线视频精品专区| 最新亚洲人成无码网站| 国产精品无码午夜福利| 女女互磨互喷水高潮les呻吟| 国内精品伊人久久久久777 | 亚洲精品一区二区三区新线路| 制服视频在线一区二区| 好爽太紧了舒服视频| 天天天狠天天碰天天爱| 日日夜夜撸啊撸| 久久亚洲一区二区三区四区| 国产精品爽黄69天堂a| 亚洲性视频免费视频网站| 久久天天躁狠狠躁夜夜2020老熟妇| 欧洲精品一线二线三线区别| 久久精品国产精品亚洲色婷婷| 国产av麻豆mag剧集| 午夜dj高清免费观看视频| 中老年熟妇激情啪啪大屁股| 亚洲午夜久久久精品影院| 久久久久国色av免费看| 色老久久精品偷偷鲁| 男人的天堂av社区在线| 7777奇米成人狠狠成人影视| 长腿校花无力呻吟娇喘的视频| 日韩超碰人人爽人人做人人添 | 欧美亅性猛交内射| 亚洲男人片片在线观看| 亚洲无碼网站观看| 蜜臀av在线播放一区二区三区| 少妇无码av无码专区线| 日本韩国的免费观看视频| 自拍偷自拍亚洲精品牛影院| 少妇高潮一区二区三区99| 国产农村妇女aaaaa视频| 一本久久伊人热热精品中文字幕| 高清国产在线拍揄自揄视频| 国产熟妇按摩3p高潮大叫| 久久久一本精品99久久精品66| 99久久国产亚洲高清观看| 国产精品日本一区二区不卡视频|