在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDK11B Antibody

  • 中文名稱:
    CDK11B兔多克隆抗體
  • 貨號:
    CSB-PA003790
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HepG2 cells using PITSLRE Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CDK11B
  • 別名:
    CDK11B antibody; CDC2L1 antibody; CDK11 antibody; PITSLREA antibody; PK58 antibody; Cyclin-dependent kinase 11B antibody; EC 2.7.11.22 antibody; Cell division cycle 2-like protein kinase 1 antibody; CLK-1 antibody; Cell division protein kinase 11B antibody; Galactosyltransferase-associated protein kinase p58/GTA antibody; PITSLRE serine/threonine-protein kinase CDC2L1 antibody; p58 CLK-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human PITSLRE.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
  • 基因功能參考文獻:
    1. These findings suggest that CDK11 is involved in the regulation of AR pathway and AR can be a potential novel prognostic marker and therapeutic target for osteosarcoma treatment. PMID: 28262798
    2. DNA methylation exists in the CDC2L1 gene promoter region in keloid tissue fibroblasts. DNA methylation of the CDC2L1 gene promoter region dramatically inhibits the expression of CDK11p58 protein in keloid tissues. PMID: 29204684
    3. CDK11 has a role in human cancers [review] PMID: 27049727
    4. we showed high expression of CDK11 in metastatic and recurrent ovarian cancer and demonstrated that CDK11 is essential for ovarian cancer cell growth and survival in vitro and in vivo. PMID: 27207777
    5. CDK11 was found associated with the TREX/THOC, which recruited this kinase to DNA. Once at the viral genome, CDK11 phosphorylated serines at position 2 in the CTD of RNAPII, which increased levels of cleavage and polyadenylation factors at the HIV 3' end. In its absence, cleavage of viral transcripts was greatly attenuated. PMID: 26567509
    6. Real-time PCR and dual-luciferase assay showed CDK11(p58) inhibited the mRNA levels of VEGF and the promoter activity of VEGF PMID: 26470709
    7. Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR expression and eIF-2alpha phosphorylation. PMID: 25576733
    8. CDK11 and CK2 expression are individually essential for breast cancer cell survival, including TNBC. PMID: 25837326
    9. CDK11(p58) kinase activity appears to be involved in early events in the establishment of the centromere protection machinery. PMID: 24436071
    10. Data indicate that CDK11p58 is an anti-metastatic gene in ERalpha-positive breast cancer and that the regulation of integrin beta3 by CDK11p58 via the repression of ERalpha signaling may constitute part of a signaling pathway underlying breast cancer invasion. PMID: 25106495
    11. silencing induces cell death in osteosarcoma PMID: 25348612
    12. CHK2 kinase constitutively phosphorylates CDK11(p110) in a DNA damage-independent manner. PMID: 23178491
    13. CDK11 is critical for the growth and proliferation of liposarcoma cells. PMID: 24007862
    14. CDK11 signaling is essential in osteosarcoma cell growth and survival, further elucidating the regulatory mechanisms controlling the expression of CDK11 and ultimately develop a CDK11 inhibitor that may provide therapeutic benefit against osteosarcoma. PMID: 22791884
    15. We have identified a correlation between two exon 7 mutations of the CDC2L1 gene and keloid disease. PMID: 22188294
    16. Since PITSLRE/CDK11 regulates autophagy in both Drosophila and human cells, this kinase represents a novel phylogenetically conserved component of the autophagy machinery. PMID: 21808150
    17. These data suggest that CDK11 may play a vital role in cell cycle re-entry in Alzheimer disease neurons in an APP-dependent manner. PMID: 21461981
    18. CDK11(p58), which accumulates only in the vicinity of mitotic centrosomes, directly interacts with the centriole-associated protein kinase Plk4 that regulates centriole number in cells. PMID: 21297952
    19. Taken together, these results provide evidence for the novel role of CDK11p46 in the regulation of translation and cell apoptosis. PMID: 21371428
    20. Thr-370 is responsible for the autophosphorylation, dimerization, and kinase activity of CDK11(p58). Moreover, Thr-370 mutants might affect CDK11(p58)-mediated signaling pathways. PMID: 21078675
    21. interaction with cyclin D3 PMID: 12082095
    22. CDK11p110 and casein kinase 2 negatively regulate tyrosine hydroxylase[TH] catecholamine biosynthetic activity since phosphoserine 19 of TH requires 14-3-3 binding for optimal enzyme activity and a decreased rate of dephosphorylation PMID: 14675149
    23. the PITSLRE IRES interacts with the Unr protein, which is more prominently expressed at the G2/M stage of the cell cycle PMID: 15330758
    24. Although hCDK11 has nearly 80% amino acid sequence identity to hCDK8, siRNA-knockdown study revealed that hCDK8 and hCDK11 possess opposing functions in viral activator VP16-dependent transcriptional regulation. PMID: 18651850
    25. CDK11(p58) is involved in the negative regulation of VDR. PMID: 19538938
    26. eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). PMID: 19854136

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性:
    Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
  • 數據庫鏈接:

    HGNC: 1729

    OMIM: 176873

    KEGG: hsa:984

    STRING: 9606.ENSP00000384442

    UniGene: Hs.651228



主站蜘蛛池模板: 精品毛片乱码1区2区3区| 胸大美女又黄的网站| 国产精品久久久久9999赢消| 中文日韩亚洲欧美制服| 小12萝裸体自慰出白浆| 熟女人妻av完整一区二区三区| 色噜噜狠狠狠狠色综合久一| 国内精品久久久久伊人av| 亚洲欧美日韩二三区在线| 噜噜色综合天天综合网mp3| 国产又爽又黄又无遮挡的激情视频 | 国产精品无码v在线观看| 人人妻人人爽人人做夜欢视频| 冲田杏梨av一区二区三区| 撕开奶罩揉吃奶高潮av在线观看 | 人妻夜夜添夜夜无码av| 色欲av无码一区二区人妻| 亚洲国产精品日本无码网站| 亚洲欲色欲色xxxxx在线| 熟妇人妻中文字幕| 久久午夜夜伦鲁鲁片无码免费| 最近中文字幕免费mv在线| 久久久久久久综合日本| 国产欧美久久一区二区| 久久精品国产亚洲a片高清不卡| 中文字幕丰满乱子无码视频| 极品新婚夜少妇真紧| 精品欧美乱码久久久久久1区2区 | 成人国产一区二区三区| 国产精品狼人久久久久影院| 免费无码成人av片在线| 拍摄av现场失控高潮数次| 熟睡人妻被讨厌的公侵犯深田咏美| 人人妻人人爽人人做夜欢视频九色| 97免费人妻在线视频| 试看120分钟做受小视频| 狠狠躁夜夜躁人人躁婷婷| 亚洲精品综合欧美一区二区三区| 国产免费又色又爽粗视频| 国产亚洲精品久久久ai换| 国内芒果精品自线一区2021|