在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CDCA7L Antibody

CDCA7L Antibody

  • 中文名稱：
    CDCA7L兔多克隆抗體
  • 貨號：
    CSB-PA850301LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA850301LA01HU diluted at 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA850301LA01HU diluted at 1:400 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CDCA7L Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CDCA7L
  • 別名：
    c Myc Interacting protein JPO2 antibody; CDA7L_HUMAN antibody; Cdca7l antibody; Cell division cycle-associated 7-like protein antibody; DKFZp762L0311 antibody; HR1 antibody; JPO2 antibody; Protein JPO2 antibody; R1 antibody; RAM2 antibody; Transcription factor RAM2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Cell division cycle-associated 7-like protein (14-167AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CDCA7L Antibody (CSB-PA850301LA01HU)，的標記方式是Non-conjugated。對于CDCA7L Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA850301LB01HU CDCA7L Antibody, HRP conjugated ELISA
    FITC CSB-PA850301LC01HU CDCA7L Antibody, FITC conjugated
    Biotin CSB-PA850301LD01HU CDCA7L Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
  • 基因功能參考文獻：
    1. Suppression of CDCA7L limits multiple myeloma proliferation through apoptosis. PMID: 27882933
    2. We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma PMID: 27013196
    3. common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN PMID: 26245978
    4. The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 and MYC. PMID: 25480495
    5. Data indicate that JPO2 and LEDGF/p75 interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75. PMID: 24634210
    6. CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC progression. PMID: 24141559
    7. Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A protein levels within the major depressive disorder groups compared with controls. PMID: 21654740
    8. monoamine oxidase A activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 PMID: 16728402
    9. demonstrates the functions of MAO A and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways PMID: 16829576
    10. Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 PMID: 17669426

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
  • 組織特異性：
    Ubiquitous. Overexpressed in medulloblastoma.
  • 數據庫鏈接：

    HGNC: 30777

    OMIM: 609685

    KEGG: hsa:55536

    STRING: 9606.ENSP00000383986

    UniGene: Hs.744069



主站蜘蛛池模板： 亚洲日韩av在线观看| 成人黄网站高清免费视频| 好爽好舒服要高潮了视频| 亚洲精品一区国产精品| 丰满诱人的人妻3| 精品午夜国产福利观看| 免费无码久久成人网站入口 | 国产人妻高清国产拍精品| 国产精品久久久国产盗摄| 欧美日韩亚洲tv不卡久久| 四库影院永久四虎精品国产| 人人妻人人澡人人爽久久av| 日本欧美久久久久免费播放网| 国产 校园 另类 小说区| 亚洲精品无码鲁网午夜| 亚洲日韩精品a∨片无码| 99精品国产再热久久无毒不卡 | yy6080久久伦理一区二区| 日韩午夜理论免费tv影院| 国产日产欧产精品品不卡| 国产精品美女久久久网av| 欧美成人va免费看视频| 少妇无码精油按摩专区| 国产精品人妻久久久久| 色偷偷888欧美精品久久久| 国产成av人片在线观看天堂无码 | 精品亚洲欧美自拍| 国产成人精品精品日本亚洲| 狠狠色婷婷久久综合频道毛片| 国产免国产免费| 国产在线精品一区二区三区直播| 一本大道大臿蕉视频无码| 全免费又大粗又黄又爽少妇片 | 久久久久亚洲精品成人网| 亚洲午夜福利在线观看| 亚洲综合av色婷婷五月蜜臀| 小草国产精品情侣| 国产精品成人精品久久久| 国精品无码人妻一区二区三区| 欧美日韩不卡高清在线看| 伊人久久大香线蕉无码不卡|