在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CDCA2 Antibody

CDCA2 Antibody

  • 中文名稱：
    CDCA2兔多克隆抗體
  • 貨號：
    CSB-PA124174
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from 293 cells, using CDCA2 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CDCA2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CDCA2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human CDCA2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
  • 基因功能參考文獻(xiàn)：
    1. The p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently of Galphai, the kinase Aurora A, and the phosphatase PP2A. PMID: 29222185
    2. Repo-Man/PP1 regulates the formation of heterochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochromatin protein 1 binding and H3K27me3 recruitment. PMID: 28091603
    3. Here the authors show how Ki-67 and RepoMan form mitotic exit phosphatases by recruiting PP1, how they distinguish between distinct PP1 isoforms and how the assembly of these two holoenzymes are dynamically regulated by Aurora B kinase during mitosis. PMID: 27572260
    4. Inhibition of cell division cycle associated 2 (CDCA2) suppressed the proliferation of lung adenocarcinoma (LAC) cells via G1 phase arrest by downregulating cyclin E1(CCNE1), while overexpression of CDCA2 promoted LAC cells proliferation by upregulating CCNE1. PMID: 28423619
    5. Results report that BubR1 and RepoMan bind directly to PP2A-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser residue enhances binding. RepoMan and BubR1 bind B56 using both hydrophobic and electrostatic interactions. PMID: 27998540
    6. Aurora B phosphorylates Repo-Man at S893, preventing its recruitment by histones. PMID: 23746640
    7. Proteomic identification of a large number of novel RepoMan interactors. PMID: 23362328
    8. Data indicate that CDCA2 frequently is overexpressed in oral squamous cell carcinoma (OSCC) and might be associated with OSCC progression by preventing cell-cycle arrest and apoptosis. PMID: 23418564
    9. It was shown that Repo-Man and Sds22 contribute to timely Aurora B kinase substrate dephosphorylation on anaphase chromatin. PMID: 22801782
    10. This study demonistrated that identify Repo-Man as a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit. PMID: 21820363
    11. Repo-Man promotes H3T11ph dephosphorylation by an indirect mechanism but directly and specifically targets H3T3ph for dephosphorylation by associated PP1gamma. PMID: 21514157
    12. This study reports essential DNA damage response regulation mediated by Repo-Man-protein phosphatase 1 and further delineate underlying mechanisms. PMID: 20188555
    13. Repo-Man forms an essential complex with protein phosphatase 1 (PP1) gamma and is required for the recruitment of PP1 to chromatin PMID: 16492807

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14623

    KEGG: hsa:157313

    STRING: 9606.ENSP00000328228

    UniGene: Hs.33366



主站蜘蛛池模板： 日日噜狠狠噜天天噜av| 国产精品无码专区av在线播放| 国产精品福利视频萌白酱| 另类亚洲综合区图片区小说| 蜜臀av在线无码国产| 亚洲 卡通 欧美 制服 中文| 人妻精品久久久久中文字幕69| 精品午夜福利1000在线观看| 韩产日产国产欧产| 色综合 图片区 小说区| 美女黄网站18禁免费看| 国产成人av 综合 亚洲| 午夜影视免费| www国产成人免费观看视频| 国产mv在线天堂mv免费观看| 五月婷婷久久草| 中文字幕乱偷无码av先锋| а天堂中文官网| 国产成人无码av在线影院| 最近2019中文字幕在线| 精品无人国产偷自产在线| 奇米影视777四色米奇影院| 少妇高潮无套内谢| 国产永久免费观看的黄网站| 中文字幕无码精品亚洲资源网久久| 无码成人aaaaa毛片| 老司机导航亚洲精品导航| 亚洲国产成人久久一区| 亚洲无人区一区二区三区| 色拍拍在线精品视频| 久热在线这里只有精品国产| 熟女乱牛牛视频在线观看| 性高朝久久久久久久| 国产色在线 | 亚洲| 久久无码中文字幕无码| 国产在线视频主播区| 在线播放免费人成视频在线观看 | 午夜精品久久久久久久喷水| 欧美亚洲精品中文字幕乱码 | 狠狠人妻久久久久久综合| 欧美日韩在手机线旡码可下载|