在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDC37 Antibody

  • 中文名稱:
    CDC37兔多克隆抗體
  • 貨號:
    CSB-PA160889
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA160889(CDC37 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA160889(CDC37 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA160889(CDC37 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CDC 37 antibody; Cdc37 antibody; CDC37 cell division cycle 37 homolog antibody; CDC37 cell division cycle 37 S cerevisiae homolog antibody; CDC37 cell division cycle 37; S cerevisiae; homolog of antibody; Cdc37 homolog antibody; CDC37 protein antibody; CDC37_HUMAN antibody; CDC37A antibody; cell division cycle 37 antibody; Cell division cycle 37 homolog antibody; Hsp90 chaperone protein kinase targeting subunit antibody; Hsp90 chaperone protein kinase targeting subunit p50Cdc37 antibody; Hsp90 chaperone protein kinase-targeting subunit antibody; Hsp90 co chaperone Cdc37 antibody; Hsp90 co-chaperone Cdc37 antibody; p50 antibody; p50Cdc37 antibody; S cerevisiae hypothetical protein CDC37 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human CDC37
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
    IHC 1:15-1:50
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
  • 基因功能參考文獻:
    1. Study showed that Cdc37 gene was up-regulated in human colorectal adenocarcinoma (CRC). Furthermore, knockdown of Cdc37 effectively reduced cell proliferation activity, enhanced apoptosis, and inhibited G1-S transition in CRC cells, and vice versa. For the mechanism, Cdc37 increased CDK4 stability to promote the phosphorylation of RB1, which finally promoted the progression of CRC. PMID: 29288563
    2. During the kinase chaperone cycle, Cdc37 phosphorylated at Y298 acts as a platform for docking of non-receptor tyrosine kinases through their regulatory domains to drive the coupled Hsp90 phosphorylation at Y197 and specifically regulate kinase chaperoning. PMID: 29343704
    3. findings suggested that this mechanism may be exploited by the Hsp90-Cdc37 chaperone to recruit and protect intrinsically dynamic kinase clients from degradation PMID: 29267381
    4. The results suggest a re-evaluation of the role of Cdc37 in the kinase lifecycle, and suggest that such interactions potentially allow kinases to more rapidly respond to key signals while simultaneously protecting unstable kinases from degradation and suppressing unwanted basal activity. PMID: 28784328
    5. Niclosamide ethanolamine disrupted the interaction between cell division cycle 37 and heat shock protein 90 in hepatocellular carcinoma, reducing tumor growth. PMID: 28284560
    6. Cdc37 performs a quality control of protein kinases, including b-raf, where induced conformational instability acts as a "flag" for Hsp90 dependence and stable cochaperone association. PMID: 27105117
    7. Ulk1 promoted the degradation of Hsp90-Cdc37 client kinases, resulting in increased cellular sensitivity to Hsp90 inhibitors. Thus, our study provides evidence for an anti-proliferative role of Ulk1 in response to Hsp90 inhibition in cancer cells PMID: 28073914
    8. The authors find that the interaction between sB-Raf and the Hsp90 chaperone system is based on contacts with the M domain of Hsp90, which contributes in forming the ternary complex with Cdc37 as long as the kinase is not stabilized by nucleotide. PMID: 27620500
    9. Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes. PMID: 26511315
    10. Suppressing expression of the cochaperone CDC37 in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth. PMID: 25098386
    11. Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37 PMID: 24869908
    12. The N-terminal tail serves as an intramolecular chaperone ensuring that CDC37 assumes one of two interconvertible states in a manner impacting the interaction of the client binding N-domain and the MC-domains, involved in dimerization and HSP90 binding. PMID: 25619116
    13. CDC37 has an important role in chaperoning protein kinases; it stabilizes kinase clients by a mechanism that is not dependent on a substantial direct interaction between CDC37 and HSP90, but requires HSP90 activity PMID: 24292678
    14. As a novel Hsp90 inhibitor, FW-04-806 binds to the N-terminal of Hsp90 and inhibits Hsp90/Cdc37 interaction, resulting in the disassociation of Hsp90/Cdc37/client complexes and the degradation of Hsp90 client proteins. PMID: 24927996
    15. CDC37 is a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors PMID: 23584476
    16. SGK3 stability and kinase activation are regulated by the Hsp90-Cdc37 chaperone complex. PMID: 24379398
    17. Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites. PMID: 23569206
    18. ERK5 interacts with the Hsp90-Cdc37 chaperone in resting cells, and inhibition of Hsp90 or Cdc37 results in ERK5 ubiquitylation and proteasomal degradation. PMID: 23428871
    19. an essential role for surface Cdc37 in concert with HSP90 on the cell surface during cancer cell invasion processes PMID: 22912728
    20. A series of tyrosine phosphorylation events, involving both p50(Cdc37) and Hsp90, are minimally sufficient to provide directionality to the chaperone cycle. PMID: 22727666
    21. Data show that part of the normal clearance cascade for TDP-43 involves the Cdc37/Hsp90 complex. PMID: 22674575
    22. Cdc37-mediated direct interaction between Hsp90/Cdc37 and an IRE1alpha cytosolic motif is important to maintain basal IRE1alpha activity and contributes to normal protein homeostasis and unfolded protein response under physiological stimulation. PMID: 22199355
    23. The primary mechanisms by which apigenin kill multiple myeloma cells is by targeting the trinity of CK2-Cdc37-Hsp90. PMID: 21871133
    24. the Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics PMID: 21367866
    25. Hsp90-Cdc37 complex acta as an endogenous regulator of noncanonical p38alpha activity. PMID: 20299663
    26. Tnf-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. PMID: 11864612
    27. role in regulating Hsp90 ATPase activity PMID: 11916974
    28. CDC37 binds to Akt and HSP90 in the signal transduction pathway in human tumor cells PMID: 12176997
    29. Results show that Cdc37 and heat shock protein 90 bind specifically to the kinase domain of LKB1. PMID: 12489981
    30. phosphorylation of Cdc37 on Ser13 is critical for its ability to coordinate Hsp90 nucleotide-mediated conformational switching and kinase binding PMID: 12930845
    31. Heteromeric comlpexes containing the molecular chaperones Hsp90 and Cdc37/p50 interacts with the kinase domain of LKB1. PMID: 14668798
    32. the interaction of Cdc37 with its client protein kinases requires amino acid residues within a motif that is present in many protein kinases PMID: 14701845
    33. Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling PMID: 15001580
    34. the Hsp90.Cdc37 molecular chaperone module has a central role in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors PMID: 15647277
    35. Cdc37 is found to heterodimerize with heat-shock protein 90 (Hsp90)-associating relative of Cdc37 (Harc) in vitro. PMID: 15850399
    36. Nuclear magnetic resonance study of binding to to HSP90. PMID: 16132836
    37. results suggest that a region of Cdc37 other than the client-binding site may be responsible for discriminating client protein kinases from others PMID: 16156789
    38. JAK1/2 are client proteins of Hsp90 alpha and beta; Hsp90 and CDC37 play a critical role in types I and II interferon pathways PMID: 16280321
    39. N-terminal glycine-rich loop of protein kinases is essential for physically associating with Cdc37. PMID: 16611982
    40. The data shows the expression and purification of an Hsp90-Cdc37-Cdk4 complex, defining its stoichiometry, and determining its 3D structure by single-particle electron microscopy. PMID: 16949366
    41. these observations support the hypothesis that there is a specific coordination between the activation of the cytosolic Ah receptor and the c-Src- and cdc37-containing HSP90 complex. PMID: 17223712
    42. The present data denote Hsp90-Cdc37 as a transiently acting essential regulatory component of IKK signaling. PMID: 17728246
    43. identify Pink1 as a novel Cdc37/Hsp90 client kinase PMID: 18003639
    44. Cdc37 is essential for maintaining prostate tumor cell growth and may represent a novel target in the search for multitargeted therapies. PMID: 18089825
    45. These data reveal a cyclic regulatory mechanism for Cdc37, in which its constitutive phosphorylation is reversed by targeted dephosphorylation in Hsp90 complexes. PMID: 18922470
    46. CDC37 in concert with HSP90 plays an essential role in maintaining oncogenic protein kinase clients including ERBB2, CRAF, CDK4, CDK6, & phosphorylated AKT. PMID: 18931700
    47. The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy. PMID: 19073599
    48. C-terminal tail and determinants in the alphaE-helix of the catalytic domain allows the chaperones Hsp90 and Cdc37 to bind newly synthesized PKC beta II, a required event in the processing of PKC by phosphorylation PMID: 19091746
    49. celastrol may represent a new class of Hsp90 inhibitor by modifying Hsp90 C terminus to allosterically regulate its chaperone activity and disrupt Hsp90-Cdc37 complex. PMID: 19858214

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    CDC37 family
  • 數據庫鏈接:

    HGNC: 1735

    OMIM: 605065

    KEGG: hsa:11140

    STRING: 9606.ENSP00000222005

    UniGene: Hs.160958



主站蜘蛛池模板: 国产精品美女久久久久久| 久久人妻xunleige无码| 波多野结衣av高清一区二区三区| 日韩中文亚洲欧美视频二| 亚洲国产av美女网站| 爆爽久久久一区二区又大又黄又嫩| 新版天堂资源中文www连接| 国产未成女一区二区| 久久婷婷成人综合色综合 | 无码h肉动漫在线观看免费| 国产精品久久人妻互换| 97久久精品人人做人人爽| 无码中文字幕色专区| 国产高清japanese在线播放e| 99999久久久久久亚洲| 日韩欧美mv在线观看免费| 国产精品毛片无遮挡高清| 夜夜爽夜夜叫夜夜高潮漏水| 夜色约爱网站| 黑人大战欲求不满人妻| 国产涩涩视频在线观看| 午夜精品久久久久久久久久久久 | 香港三级精品三级在线专区| 亚欧洲精品在线视频免费观看| 久久亚洲精品国产精品婷婷| 又色又爽又黄还免费毛片96下载| 台湾无码一区二区| 久久久久国产一区二区三区| 国产在线观看免费观看不卡| 亚洲中字慕日产2020| 人妻av中文字幕久久| 亚洲欧美精品伊人久久| 人妻久久久精品99系列2021| 国产牛仔裤网站精品| 国产色爱av资源综合区| 男ji大巴进入女人的视频小说| 97se亚洲综合自在线| 日日av拍夜夜添久久免费| 亚洲伊人久久综合影院| 中文字幕人妻无码专区| 欧美成人性做爰77777|