在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CD8B Antibody

CD8B Antibody

  • 中文名稱：
    CD8B兔多克隆抗體
  • 貨號：
    CSB-PA004967ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004967ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004967ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CD8B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD8B; CD8B1; T-cell surface glycoprotein CD8 beta chain; CD antigen CD8b
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human T-cell surface glycoprotein CD8 beta chain protein (22-170AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
  • 基因功能參考文獻：
    1. results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 and Annexin A2. The pathway downstream this interaction needs to be explored PMID: 28976984
    2. [review] Coreceptor CD8alphabeta contributes to the antigen-recognition process by binding to a largely invariant region of the MHCI molecule and by promoting intracellular signaling. PMID: 21954283
    3. A clustering of DNase hypersensitivity sites and matrix attachment regions capable of binding SATB1 and GATA-3, colocalized at the 3' end of the CD8B gene, suggests that this region is an epigenetic regulator of CD8 expression. PMID: 11937547
    4. RT-PCR, and related methodologies are not useful substitutes for assessment of CD4 and CD8 cell numbers in HIV-infected persons. PMID: 12702212
    5. study demonstrated differential mRNA expression patterns of CD8beta splice variants in thymocytes and in resting, memory, and activated primary CD8(+) T cells PMID: 18490743

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 8]: Secreted.
  • 組織特異性：
    Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in pe
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1707

    OMIM: 186730

    KEGG: hsa:926

    STRING: 9606.ENSP00000331172

    UniGene: Hs.405667



主站蜘蛛池模板： 色又黄又爽18禁免费视频| 色135综合网| 久久人妻无码一区二区| 国产天堂久久天堂av色综合| 久久国产精品日本波多野结衣| 亚洲精品久久久久一区二区| 国色天香中文字幕在线视频| 中国熟妇牲交视频| 色综合天天天天综合狠狠爱| 四虎成人精品一区二区免费网站| 成人免费视频一区二区三区| 琪琪电影午夜理论片八戒八戒| 99精品丰满人妻无码a片| 亲子乱子伦xxxx视频| 亚洲国产精品久久精品| 精品国产免费一区二区三区| 亚洲综合一区国产精品| 野外亲子乱子伦视频丶| 日韩成人无码中文字幕| 麻豆精品一卡二卡三卡| 国产福利在线永久视频| 午夜大片免费男女爽爽影院| 99精品国产在热久久无码| 亚洲国产成av人天堂无码| 久久精品人妻中文系列| 奇米影视第四色首页| 久久视频这里有精品33| 人妻丰满熟妇av无码区动漫| 亚洲精品nv久久久久久久久久| 精品国产一区av天美传媒| 精品一卡二卡三卡四卡网站| 亚洲乱色熟女一区二区三区丝袜 | 亚洲va久久久噜噜噜久久无码| 久久99精品九九九久久婷婷| 国精品人妻无码一区二区三区喝尿| 久久不见久久见www免费| 亚洲成_人网站图片| 西西人体www大胆高清视频| 精品亚洲一区二区三区在线播放| 2021精品亚洲中文字幕| 久久av高清无码|