在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CD79A Antibody

CD79A Antibody

  • 中文名稱：
    CD79A兔多克隆抗體
  • 貨號：
    CSB-PA080055
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CD79A; IGA; MB1; B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD antigen CD79a
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD79a.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
  • 基因功能參考文獻：
    1. The incidence of MYD88 and CD79B mutations in patients with CD5(+) DLBCL is lower than that in patients with DLBCL-SS, suggesting that CD5(+) DLBCL is not the same disease as DLBCL-SS in terms of gene mutation status. PMID: 27915469
    2. Phosphorylation of CD79a causes a decrease in helical propensity in the C-terminal region, for CD79b, the opposite was observed and phosphorylation resulted in an increase of helical propensity in the C-terminal part. PMID: 24769851
    3. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
    4. CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy. PMID: 24146823
    5. STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL. PMID: 21324920
    6. CD79a may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma PMID: 20102401
    7. Unlike the B29 octamer motif, the mb-1 octamer motif does not have the essential sequence required for OBF-1/Bob1 interaction, therefore its promoter is not transactivated by OBF-1/Bob1. PMID: 11907094
    8. B cell-restricted mb-1 gene: expression, function, and lineage infidelity. Review. PMID: 12403343
    9. There is a somatic hypermutation of this gene in B-cell lymphoma and multiple myeloma. PMID: 12651942
    10. Results indicate that PAX5 is a more specific marker than CD79a for B-cell ALL diagnosis. PMID: 15492262
    11. lower levels of B-cell receptor surface expression observed in chronic lymphocytic leukemia are accounted for by an impaired glycosylation and folding of the mu and CD79a chains. PMID: 15591116
    12. FISH findings indicate that CD79a, despite its specificity for B-cell differentiation, represented the aberrant presence of a B-cell antigen in leukemias of distinct myeloid linage. PMID: 16271957
    13. Acute leukemia with t(8;21) coexpresses CytCD79a represent biphenotypic acute leukemia. PMID: 17350472
    14. Anti-CD79b antibodies downregulated surface B-cell receptor and were trafficked to the lysosomal-like major histocompatibility complex class II-positive compartment of a mouse xenograft model of non-Hodgkin lymphoma. PMID: 17374736
    15. Ig-alpha was phosphorylated in all myeloma IgG BCR isolates, the 31-kD variant being phosphorylated most frequently. It was not phosphorylated in normal control B cells. PMID: 17701175
    16. Median survival time of cytoplasmic CD79 alpha positive group was shorter than that of cytCD79a negative group in acute myeloid leukemia. PMID: 18160827

    顯示更多

    收起更多

  • 相關疾病：
    Agammaglobulinemia 3, autosomal recessive (AGM3)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    B-cells.
  • 數據庫鏈接：

    HGNC: 1698

    OMIM: 112205

    KEGG: hsa:973

    STRING: 9606.ENSP00000221972

    UniGene: Hs.631567



主站蜘蛛池模板： 亚洲a∨国产av综合av| 伊人久久精品一区二区三区| 国产男女爽爽爽免费视频| 人妻无码一区二区三区av| 亚洲国产精品久久久天堂不卡海量 | 久久国产乱子伦精品免费午夜 | 人妻洗澡被强公日日澡| 国色天香网www在线观看| 男女爽爽无遮挡午夜视频| 香港三日本三级少妇三级66| 欧洲多毛裸体xxxxx| 好日子在线观看视频大全免费动漫| 国产成年女人毛片80s网站| 成人综合婷婷国产精品久久蜜臀 | 亚洲精品第一国产综合境外资源| 亚洲色无码专区一区| 97在线观看永久免费视频| 狠狠综合久久久久尤物丿| 国产高清午夜人成在线观看| 亚洲 卡通 欧美 制服 中文| 欧美日韩在线视频一区| 日本欧美大码a在线观看| 国产在线无码一区二区三区| 亚洲图片综合图区20p| 亚洲精品久久久久久久久久久 | 欧美精品人人做人人爱视频| 一进一出抽搐gif| 欧美熟妇丰满肥白大屁股免费视频| 午夜福利视频一区二区手机免费看| 国产又爽又粗又猛的视频| 精品女同一区二区三区免费站| 国产成人影院一区二区三区| 天干天干啦夜天干天天爽| 韩国三级丰满少妇高潮| 久久精品2021国产| 人人妻人人澡人人爽偷拍台湾| 在线成人一区二区| 精品无人区一区二区三区| 亚洲国产精品久久久久4婷婷| 377人体粉嫩噜噜噜| 国产一区二区三区影院|