在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CD6 Antibody

  • 中文名稱:
    CD6兔多克隆抗體
  • 貨號:
    CSB-PA134350
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Jurkat cells, using CD6 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CD6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human CD6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
  • 基因功能參考文獻:
    1. This study provides evidence that CD6 is involved in the susceptibility to Behcet's disease in a Chinese Han population. PMID: 27108704
    2. These results suggest that (i) CD6 is a negative regulator of T-cell activation, (ii) at the same time, CD6 is a positive regulator of activated T-cell survival/proliferation and infiltration; and (iii) CD6 is a potential new target for treating multiple sclerosis (MS)and potentially other T-cell-driven autoimmune conditions. PMID: 28209777
    3. These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6. PMID: 28289074
    4. Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen and linker for activation of T cells protein (LAT) phosphotyrosine (pTyr) peptides. PMID: 27896837
    5. Results from recent genetic association studies provide evidence for a role of CD6 in multiple sclerosis and in rheumatoid arthritis pathogenesis. [review] PMID: 26844569
    6. Study provides evidence on the role of CD6, a lymphocyte-specific surface receptor from to the ancient and highly conserved Scavenger Receptor Cysteine-Rich (SRCR) superfamily, as a pattern recognition receptor, and the functional consequences this may have on T cell activation and differentiation. [review] PMID: 25777272
    7. Data show the multiple aspects that determine the nature of the signals transmitted via CD6 and the context that may define a dual role for this important T cell surface molecule. [review] PMID: 26028048
    8. Data show a role for extracellular and intracellular interactions of CD6 in lateral movement in response to T cell activation. [review] PMID: 26302795
    9. The binding sites on CD6 and CD166 have been characterized to show that a SNP in CD6 causes glycosylation that hinders the CD6/CD166 interaction. PMID: 26146185
    10. CD6 regulatory T cells are characterized by CD6 expression and FOXP3 expression. PMID: 25088497
    11. interaction of Galectin-1 and -3 with CD6 PMID: 24945728
    12. upon T cell activation, SRSF1 becomes limiting, and its function in CD6 exon 5 splicing is countered by an increase in CD6 transcription, dependent on chromatin acetylation. PMID: 24890719
    13. The CD6 polymorphism conferred reduced odds of optic neuritis as an attack location PMID: 24130718
    14. In a Korean population, one SNP in CD6 was associated with neuromyelitis optica. PMID: 22994200
    15. Our findings reveal that this new MS-associated CD6 risk haplotype significantly modifies expression of CD6 on CD4(+) and CD8(+) T cells. PMID: 23638056
    16. A novel level of regulation of CD6 function by intracytoplasmic serine phosphorylation. PMID: 23711376
    17. Data suggest that genetic variations within CD6 and syntaxin binding protein 6 (STXBP6) may influence response to TNFalpha inhibitors in patients with rheumatoid arthritis (RA). PMID: 22685579
    18. Cd6 is a signaling attenuator whose expression alone, i.e. in the absence of ligand engagement, is sufficient to restrain signaling in T cells. PMID: 21956609
    19. These findings indicate that the multiple sclerosis risk allele in the CD6 locus is associated with altered proliferation of CD4(+) T cells PMID: 21849685
    20. CD6 expression on peripheral NK cells marks a novel CD56(dim) subpopulation associated with distinct patterns of cytokine and chemokine secretion. PMID: 21178331
    21. association of single nucleotide polymorphisms to multiple sclerosis PMID: 21552549
    22. CD6+ B cells are diminished in Sjogren's syndrome PMID: 20810246
    23. Data show that CD6-ALCAM interaction in vitro induced a synergistic co-stimulation of normal peripheral blood mononuclear cells. PMID: 20726988
    24. Study reinforces a role for CD6 and TNFRSF1A as risk loci for multiple sclerosis, extending to populations of southern European ancestry. PMID: 20430450
    25. CD6 associates with the scaffolding PDZ-containing protein syntenin-1 during maturation of the immunological synapse PMID: 16034076
    26. Engagement of CD6 with CD166 on tumor cells plays an important role in gammadelta T cell activation by tumor cells sensitized with nonpeptide antigens endogenously or exogenously. PMID: 16818742
    27. the CD6-ALCAM interaction results in activation of the three MAP kinase cascades, likely influencing the dynamic balance that determines whether resting or activated lymphocytes survive or undergo apoptosis. PMID: 16818773
    28. The costimulatory effect of CD6 is mediated through phosphorylation-dependent binding of a specific tyrosine residue, 662Y, in its cytoplasmic region to the adaptor SLP-76. PMID: 16914752
    29. Unprecedented bacterial binding properties of recombinant soluble CD6 support its therapeutic potential for the intervention of septic shock syndrome or other inflammatory diseases of infectious origin. PMID: 17601777
    30. A chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. PMID: 18707547
    31. Replication in an independent set of 2,215 subjects with multiple sclerosis (MS) and 2,116 control subjects validates new MS susceptibility loci at TNFRSF1A, IRF8 and CD6; TNFRSF1A harbors two independent susceptibility alleles. PMID: 19525953
    32. Comprehensive profiling of the cell surface proteome provides an effective approach for the identification of commonly occurring proteins as well as proteins with restricted expression patterns in this compartment. PMID: 12493773

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.; [Soluble CD6]: Secreted.
  • 組織特異性:
    Detected on thymocytes. Detected on peripheral blood T-cells. Detected on natural killer (NK) cells. Soluble CD6 is detected in blood serum (at protein level). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes. Expressed by
  • 數據庫鏈接:

    HGNC: 1691

    OMIM: 186720

    KEGG: hsa:923

    STRING: 9606.ENSP00000323280

    UniGene: Hs.744366



主站蜘蛛池模板: 免费裸体黄网站18禁免费| 狠狠躁天天躁中文字幕| 亚洲日韩中文第一精品| 亚洲熟妇无码av另类vr影视| 国产精品真实灌醉女在线播放| 亚洲欧美成人精品香蕉网| 国产乱人无码伦av在线a| 久久精品亚洲一区二区三区浴池| 欧美人禽杂交狂配免费看| 少妇精品视频无码专区| 国语自产少妇精品视频| 国产精品亚洲一区二区三区喷水 | 国产在线 | 中文| 国产爆乳无码视频在线观看| 日韩精品专区在线影院重磅| 一本大道东京热无码| 男女裸交免费无遮挡全过程| 无码少妇一区二区浪潮免费| 香草乱码一二三四区别| 国精产品999国精产品官网| 亚洲精品久久久久久动漫器材一区| 亚洲日韩看片成人无码| 国产精品玩偶在线观看| 久久婷婷五月国产色综合| 无码高潮又爽又黄a片软件| 国产福利无码一区在线| 艳妇荡女欲乱双飞两中年熟妇 | 天堂网在线观看| 亚洲a成人片在线观看| 亚洲欧洲自拍拍偷精品 美利坚| 四虎成人国产精品永久在线 | 欧美成人精品三级一二三在线观看 | 精品女同一区二区| 国产精品久久777777| 亚洲日韩日本中文在线| 熟妇的奶头又大又粗视频| 亚洲第一av网站| 免费国产乱理伦片在线观看| 午夜一区二区亚洲福利| 国产欧美日韩综合精品二区| 国产成人精品日本亚洲一区|