在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CD320 Antibody

  • 中文名稱:
    CD320兔多克隆抗體
  • 貨號:
    CSB-PA004924GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CD320
  • 別名:
    8D6 antibody; 8D6 antigen antibody; 8D6A antibody; CD320 antibody; CD320 antigen antibody; CD320_HUMAN antibody; FDC-signaling molecule 8D6 antibody; FDC-SM-8D6 antibody; TCblR antibody; Transcobalamin receptor antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human CD320
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.
  • 基因功能參考文獻:
    1. It has been proposed that the transcobalamin 2 receptor (TCN2R) is associated with idiopathic recurrent spontaneous abortion (RSA). The findings showed no significant association between TCN2R rs2336573 polymorphisms and the risk/protection of recurrent spontaneous abortion. PMID: 29537328
    2. the crystal structure of human holo-transcobalamin (TC) in complex with the extracellular domain of CD320, visualizing the structural basis of the TC-CD320 interaction, is reported. PMID: 27411955
    3. There was no significant difference in the expression of soluble csf CD320 between patients and controls. PMID: 28486088
    4. Although not significant when corrected for multiple testing, eight single nucleotide polymorphisms (SNPs) in two genes, transcobalamin II (TCN2) and the transcobalamin II-receptor (TCblR), were found to influence several clinical traits of cobalamin deficiency. PMID: 25657319
    5. The soluble transcobalamin receptor is present in cerebrospinal fluid and correlates to dementia-related biomarkers tau proteins and amyloid-beta. PMID: 26205293
    6. Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and transcobalamin II receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion PMID: 24750446
    7. The high urinary concentration and the strong correlation between urinary and serum sCD320 suggests that sCD320 is filtered in the kidney. PMID: 24015289
    8. Data indicate that only the extracellular region (aa 32-229) of TCblR/CD320 is needed for transcobalamin-cobalamin (TC-Cbl) binding. PMID: 23603833
    9. Proliferating cancer cells express measurable levels of TCII and TCII-R. PMID: 24122983
    10. TCblr SNP were associated with omphalocele suggests that disruption of methylation reactions, in which folate, vitamin B12, and homocysteine play critical parts, may be a risk factor for omphalocele. PMID: 22116453
    11. Our data suggest that variation in TCblR plays a role in neural tube defect risk and that these variants may modulate cobalamin metabolism. PMID: 20577008
    12. the cell cycle associated expression of TCblR appears to be tightly regulated in synchrony with the proliferative phase of the cell cycle. PMID: 20627121
    13. Analysis of TCblR/CD320, the gene for the receptor for cellular uptake of transcobalamin-bound cobalamin, identified a homozygous single codon deletion, c.262_264GAG (p.E88del), resulting in the loss of a glutamic acid residue. PMID: 20524213
    14. Confocal microscopy of tonsil sections revealed co-localization of CD320 with CD19 and CD38 but not with CD3 indicating that germinal center B cells expressed CD320 in addition to follicular dendritic cells. PMID: 19123977
    15. This gene encodes a receptor for cellular uptake of transcobalamin-bound vitamin B12. PMID: 18779389

    顯示更多

    收起更多

  • 相關疾病:
    Methylmalonic aciduria, transient, due to transcobalamin receptor defect (MMATC)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Detected in the germinal center (GC) of lymphoid follicles (at protein level). Expressed abundantly on follicular dendritic cells (FDCs).
  • 數據庫鏈接:

    HGNC: 16692

    OMIM: 606475

    KEGG: hsa:51293

    STRING: 9606.ENSP00000301458

    UniGene: Hs.558499



主站蜘蛛池模板: 日本在线视频www鲁啊鲁| yyyy11111少妇影院| 俺去啦俺来也五月天| 亚洲人精品亚洲人成在线 | 国产亚洲精品成人aa片| 亚洲乱亚洲乱妇50p| 色午夜一av男人的天堂| 碰超免费人妻中文字幕| 99r在线精品视频在线播放| 亚洲aⅴ天堂av天堂无码| 三上悠亚ssⅰn939无码播放| 疯狂撞击丝袜人妻| 成人区精品一区二区婷婷| 国产亚洲tv在线观看| 国产精品卡一卡2卡三卡网站| 国产精品成人一区二区三区| 中文字幕日韩一区二区三区不卡 | 成全世界免费高清观看| 亚洲欧洲日产最新| 体内射精日本视频免费看| 国产乱码一区二区三区| 少妇白浆高潮无码免费区| 亚洲va久久久噜噜噜久久男同| 国产日韩在线视看高清视频手机| 国产又黄又爽胸又大免费视频| 亚洲国产精品成人久久蜜臀| 国产精品毛片a∨一区二区三区| 伊人久久成综合久久影院| 让少妇高潮无乱码高清在线观看 | 一本大道东京热无码一区| 久久国产精品精品国产色婷婷| 精品国产美女av久久久久 | 亚洲精品少妇一区二区| 嫩草av久久伊人妇女超级a| 香港三级韩国三级日本三级| 欧美一区二区三区性视频| 大伊香蕉精品视频在线直播| 国产欠欠欠18一区二区| 男女真人国产牲交a做片野外| 国产精品成人一区二区不卡| 日韩 亚洲 欧美 国产 精品|