在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CD248 Antibody

Unavailable
  • 中文名稱:
    CD248兔多克隆抗體
  • 貨號:
    CSB-PA004905GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD164 sialomucin like 1 antibody; CD164L1 antibody; CD248 antibody; CD248 antigen endosialin antibody; CD248 molecule endosialin antibody; CD248_HUMAN antibody; Endosialin antibody; TEM 1 antibody; TEM1 antibody; Tumor endothelial marker 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CD248
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in tumor angiogenesis.
  • 基因功能參考文獻:
    1. These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation PMID: 28671670
    2. Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells. PMID: 28122639
    3. the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer PMID: 27635044
    4. Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis. PMID: 28126825
    5. Tumour cell endosialin expression was seen in 89% of undifferentiated pleomorphic sarcomas, 77% of adult fibrosarcomas/spindle cell sarcomas, 62% of synovial sarcomas, 51% of leiomyosarcomas and 31% of rhabdomyosarcomas. PMID: 27434038
    6. CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker. PMID: 27080864
    7. TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer PMID: 26336878
    8. MORAb-004 reduced CD248 on pericytes, impaired tumor microvasculature maturation and ultimately suppressed tumor development. PMID: 26327620
    9. The authors show that endosialin, a C-type lectin, expressed in the liver exclusively by HSC and portal fibroblasts, is upregulated in liver fibrosis in mouse and man. PMID: 25680861
    10. The genes CD248, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. PMID: 24716914
    11. new monoclonal antibodies described in this paper are domain-specific and represent important reagents for the study of functional contributions of extracellular endosialin domains PMID: 22824847
    12. [review] CD248 is a C-type lectin-like domain-containing cell surface glycoprotein that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions. PMID: 22206249
    13. CD248 defines a subset of stromal cells, including but not limited to some myofibroblasts, linked to albuminuria and tubulointerstitial damage during tissue remodeling in CKD. PMID: 21490589
    14. endosialin can be detected in advanced sarcoma PMID: 21537839
    15. Endosialin expression may be involved in the progression of rectal cancers. PMID: 21362178
    16. Results provide evidence for a TEM-1-dependent signal pathway that controls proliferation of pericytes. PMID: 20484976
    17. TEM1/endosialin was induced in the vasculature of high-grade brain tumors where its expression was inversely correlated with patient age. PMID: 19948061
    18. Endosialin colocalized with thrombomodulin, suggesting the proteins may have complementary functions in tumor progression. PMID: 15624764
    19. Endosialin is a marker of stromal fibroblasts and is not selectively expressed on tumor endothelium. PMID: 15862292
    20. results pinpoint to a molecular mechanism by which expression of endosialin/TEM1 in the tumor stroma and endothelium may support tumor progression and invasion PMID: 17986615
    21. experiments unambiguously demonstrate that endosialin is expressed by tumor-associated myofibroblasts & mural cells & not by endothelial cells; results validate endosialin as marker of tumor-associated myofibroblasts & tumor vessel-associated mural cells PMID: 18187565
    22. endosialin is not expressed in normal human adult brain but is strongly upregulated in the angiogenic vasculature of all high-grade glioma specimens examined PMID: 18192970
    23. identified extracellular endosialin ligands and identified Mac-2 BP/90K as a specific interaction partner PMID: 18490383
    24. expression of TEM1 or endosialin (CD248) and other TEM has been discovered in a population of vascular endothelial growth factor receptor 2+/CD31+/CD45-/VE-cadherin+ EPC derived from human CD133+/CD34+ cells PMID: 18723498
    25. endosialin is strongly expressed by pericytes during periods of active angiogenesis during embryonic and tumor development PMID: 18761022
    26. These findings elucidate important aspects of endosialin gene regulation PMID: 18813310

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of
  • 數據庫鏈接:

    HGNC: 18219

    OMIM: 606064

    KEGG: hsa:57124

    STRING: 9606.ENSP00000308117

    UniGene: Hs.195727



主站蜘蛛池模板: 国产又黄又硬又粗| 日本免费高清一本视频| 亚洲熟妇无码爱v在线观看| 久久精品人妻一区二区蜜桃| 国产成人亚洲综合精品| 伦理片无码电影在线看| 国产在线拍揄自揄拍无码视频| 亚洲а∨天堂久久精品2021| 无码人妻精品一区二区三区夜夜嗨| 小小拗女性bbwxxxx国产| 亚洲乱妇亚洲乱妇xinglu| 波多野结衣av无码久久一区| 国产一区二区在线影院| 国产超碰女人任你爽| 欧美性猛交内射兽交老熟妇| 99视频偷窥在线精品国自产拍| 欧美丰腴丰满大屁股熟妇| 亚洲亚洲人成综合丝袜图片| 国产亚洲精品成人aa片新蒲金| 亚洲欧美中文日韩在线v日本| 无码中文人妻在线三区| 高潮好爽视频在线观看| 无码人妻人妻经典| 无码av免费毛片一区二区| 西西人体大胆啪啪实拍| 国产欧美日韩另类精彩视频| 成人永久免费网站在线观看| 亚洲人成在线观看网站不卡 | 国产网红主播无码精品| 精品国产福利一区二区| 久久国产高潮流白浆免费观看| 狠狠色综合激情丁香五月| 久久精品免视看国产成人明星| 未满十八勿入午夜免费网站| av无码av天天av天天爽| 人妻丝袜中文无码av影音先锋专区| 秋秋影视午夜福利高清| 亚洲综合区图片小说区| 午夜射精日本三级| 亚洲第一狼人天堂久久| 综合亚洲桃色第一影院|