在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCP110 Antibody

  • 中文名稱:
    CCP110兔多克隆抗體
  • 貨號:
    CSB-PA528588ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: CCP110 antibody at 4.6μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 114, 112 kDa
      Observed band size: 114 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA528588ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA528588ESR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CCP110 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CCP110
  • 別名:
    110 kDa centrosomal protein antibody; CCP110 antibody; Centriolar coiled coil protein 110kDa antibody; Centrosomal protein 110 kDa antibody; Centrosomal protein CP110 antibody; Centrosomal protein of 110 kDa antibody; Cep110 antibody; CP110 antibody; CP110_HUMAN antibody; DKFZp781G1416 antibody; FAN antibody; KIAA0419 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Centriolar coiled-coil protein of 110 kDa protein (1-280AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
  • 基因功能參考文獻(xiàn):
    1. PLK4 specifically phosphorylates CP110 at the S98 position and is an essential step for centriole assembly. PMID: 28562169
    2. This brief communication reports on a patient with an exceedingly rare "8p11 (eight-p-eleven) myeloproliferative syndrome" (EMS) with CEP110-FGFR1 rearrangement who responded to treatment with the multi-tyrosine kinase inhibitor (TKI) dasatinib PMID: 28242791
    3. In tissues of prostate cancer patients, low CP110 and high miR-129-3p expression levels correlated with metastasi PMID: 26918338
    4. We demonstrated that restoration of CP110 expression in MDA-MB-231 and MCF-7 cells by miR-129 overexpression rendered the cells sensitive to docetaxel. PMID: 26487539
    5. Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression. PMID: 26304236
    6. CP110 plays a mechanistic role in response of lung cancer cells to CDK2 inhibition, especially in the presence of activated KRAS mutations. PMID: 25808870
    7. Centrin2 regulates primary ciliogenesis through controlling CP110 levels. PMID: 25753040
    8. Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1, TAp73 were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length PMID: 25201258
    9. using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels PMID: 23486064
    10. Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres PMID: 22441691
    11. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. PMID: 22684256
    12. Cp110 expression in mucosa from patients with chronic rhinosinusitis might contribute to the poor ciliation observed in these patients PMID: 21982113
    13. Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly. PMID: 21620453
    14. SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity PMID: 20596027
    15. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication (CP110) PMID: 12361598
    16. These data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. PMID: 16760425
    17. CP110 suppresses a cilia assembly program. PMID: 17719545
    18. The transition from centrioles to basal bodies is negatively regulated by CP11 protein. PMID: 17765674
    19. These results suggest that CEP290 cooperates with Rab8a to promote ciliogenesis and that this function is antagonized by CP110. PMID: 18694559
    20. Results suggest that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles. PMID: 19481458

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
  • 組織特異性:
    Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24342

    OMIM: 609544

    KEGG: hsa:9738

    STRING: 9606.ENSP00000370803

    UniGene: Hs.279912



主站蜘蛛池模板: 国产aⅴ精品一区二区三区| 看国产黄大片在线观看| 国产av无码专区亚洲草草| 午夜无码性爽快影院6080| 狠日狠干日日射| 无码国产精品一区二区免费式影视| 亚洲国产午夜精品理论片在线播放 | 亚洲爆乳www无码专区| 午夜爽爽爽男女污污污网站| 国产啪视频1000部免费| 国产午夜成人久久无码一区二区| www国产亚洲精品久久麻豆| 极品少妇扒开粉嫩小泬视频| 人妻在线无码一区二区三区 | 国产 麻豆 日韩 欧美 久久| 亚洲高清成人av电影网站| 久久人人97超碰caoporen | 亚洲精品久久久久午夜福利| 欧洲成人午夜精品无码区久久| 天天弄天天模| 特殊重囗味sm在线观看无码| 欧美人与动性xxxxbbbb| 午夜大片免费男女爽爽影院| 无遮挡又爽又刺激的视频| 国内精品美女a∨在线播放| 欧美性猛交xxxx乱大交| 成品人视频ww入口| 人妻中文字幕无码系列| 2021久久最新国产精品| 精品深夜av无码一区二区老年 | 亚洲精品色情app在线下载观看| 国産精品久久久久久久| 欧美日韩免费专区在线| 开心色怡人综合网站| 久久久亚洲欧洲日产国码aⅴ| 国产真实夫妇交换视频| 啪啪激情婷婷久久婷婷色五月| 暴力调教一区二区三区| 99精品国产在热久久| 97性无码区免费| 好吊妞人成视频在线观看27du|