在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCNY Antibody

  • 中文名稱:
    CCNY兔多克隆抗體
  • 貨號:
    CSB-PA004834GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CCNY
  • 別名:
    CCNY antibody; C10orf9 antibody; CBCP1 antibody; CFP1Cyclin-Y antibody; Cyc-Y antibody; Cyclin box protein 1 antibody; Cyclin fold protein 1 antibody; cyclin-X antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CCNY
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.
  • 基因功能參考文獻:
    1. increased expression of CCNY was significantly associated with cell proliferation and migration. PMID: 29557391
    2. Amplification of gene CCNY is associated with metastatic lung adenocarcinoma. PMID: 28381877
    3. we believe that CCNY has biological effect in breast cancer (BC) development, and its inhibition via an RNA interference lentiviral system may provide a therapeutic option for BC PMID: 27666310
    4. CCNY was significantly upregulated in ovarian cancer cell lines and tissues. Significant association was observed between CCNY expression and clinicopathological stage and lymph node metastasis. It significantly exacerbated proliferation, migration, and invasion of A2780 cells, in vitro and in nude mice. It significantly increased c-Myc, cyclin D1, PFTK1, ki67, and OGT protein expressions in xenograft tumor tissues. PMID: 26831658
    5. Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3. PMID: 26205494
    6. Our findings highlight a PFTK1-CCNY complex in activating noncanonical Wnt signaling in HCC cells. PMID: 24824184
    7. Human cyclin Y (CCNY) is a phosphoprotein in vivo and phosphorylation of CCNY by CDK14 triggers its ubiquitination and degradation. PMID: 24794231
    8. Cyclin Y regulates the expression and membrane trafficing of PCTAIRE kinases (PCTK). (Review) PMID: 22895054
    9. CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site. PMID: 22184064
    10. these results validated the role of CCNY as a clinically relevant human oncoprotein PMID: 21273179
    11. CCNY might play an important role in glioma tumorigenisis. PMID: 20441050
    12. Single nucleotide polymorphism in CCNY gene is associated with Crohn's disease and ulcerative colitis PMID: 18438405

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side.; [Isoform 3]: Nucleus.
  • 蛋白家族:
    Cyclin family, Cyclin Y subfamily
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 23354

    OMIM: 612786

    KEGG: hsa:219771

    STRING: 9606.ENSP00000363836

    UniGene: Hs.14745



主站蜘蛛池模板: 欧美激欧美啪啪片| 在线播放十八禁视频无遮挡| 怀孕挺大肚子疯狂高潮av毛片| 国产 制服丝袜 动漫在线| 天天躁夜夜躁av天天爽| 加勒比一本heyzo高清视频| 国产69囗曝吞精在线视频| 国产熟妇精品高潮一区二区三区| 7777奇米四色成人眼影| 蜜桃av抽搐高潮一区二区| 亚洲欧美日韩综合在线一| 亚洲国产精品久久久久网站| 漂亮人妻被黑人久久精品| 男女裸交免费无遮挡全过程| 蜜桃av无码免费看永久| 国产精品免费视频色拍拍| 四川丰满少妇被弄到高潮| 国产成人亚洲精品| 亚洲精品拍拍央视网出文| 欧美xxxx黑人又粗又长| 97久久超碰国产精品2021| 成人看的污污超级黄网站免费 | 精品久久久久久久久中文字幕| 国产精品无码a∨果冻传媒| 国产卡一卡二无线乱码| 久久青草费线频观看| 国产成人免费无码av在线播放| 久久人人97超碰国产精品| 亚洲情综合五月天| 亚洲乱码中文字幕久久孕妇黑人| 超碰97人人做人人爱亚洲尤物| 丰满多毛少妇做爰视频爽爽和| 又爽又黄又无遮挡的视频| 欧美成人精品三级一二三在线观看 | 99久久人妻精品免费二区| 国产欧美日韩视频怡春院| 精品国产一区二区av麻豆| 国产精品十八禁在线观看| 国产熟女出轨做受的叫床声| 99大香伊乱码一区二区| 欧洲精品99毛片免费高清观看|