在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CCNF Antibody

CCNF Antibody

  • 中文名稱：
    CCNF兔多克隆抗體
  • 貨號(hào)：
    CSB-PA172235
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA172235(CCNF Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: CSB-PA172235(CCNF Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CCNF
  • 別名：
    Ccnf antibody; CCNF_HUMAN antibody; Cyclin-F antibody; F box only protein 1 antibody; F-box only protein 1 antibody; FBX1 antibody; FBXO1 antibody; G2 mitotic specific cyclin F antibody; G2/mitotic specific cyclin F antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human CCNF
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle. Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability. Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity. In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability. Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry. May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB.
  • 基因功能參考文獻(xiàn)：
    1. A single missense mutation in cyclin F causes hyper-ubiquitylation of proteins that can indirectly impair the autophagy degradation pathway, which is implicated in amyotrophic lateral sclerosis pathogenesis. PMID: 28852778
    2. Cyclin F and ribonucleotide reductase family member 2 (RRM2) compose a functional axis responsible for nucleotide metabolism. Impairment in this pathway may contribute to increased DNA damage repair and drug resistance. Additionally, we analyzed the expression of RRM2 mRNA and discovered that high expression of RRM2 is associated with worse overall survival. PMID: 29767233
    3. Mutational spectrum of CCNF emphasizes the pathogenic role of CCNF mutations in ALS. PMID: 29102476
    4. Our result indicates that the mutation of CCNF is rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia from Mainland China PMID: 28281833
    5. These data indicate that the coordinated, temporal ordering of cyclin F and Cdh1 degradation, organized in a double-negative feedback loop, represents a fundamental aspect of cell-cycle control PMID: 27653696
    6. Authors demonstrated a significant correlation between the severity of the CCNF-induced axonopathy and a reduced motor response to a light stimulus (photomotor response). PMID: 28444311
    7. Cyclin F-mediated degradation of SLBP limits H2A.X accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint. PMID: 27773672
    8. cyclin F is a novel F-box protein that functions as an intrinsic cellular regulator of HIV-1 Vif and has a negative regulatory effect on the maintenance of viral infectivity by restoring APOBEC3G expression PMID: 28184007
    9. The SCYL1- BP1 affects the cell cycle through increasing steady state levels of Cyclin F and RRM2 proteins, thus constituting a dual regulatory circuit. PMID: 25980818
    10. Data indicate that a missense mutation in cyclin F (CCNF) in a large Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) family. PMID: 27080313
    11. CDC6 and Cyclin F interact through defined sequence motifs that promote CDC6 ubiquitylation and degradation. PMID: 26818844
    12. Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control. PMID: 25557911
    13. Cyclin F controls genome stability through ubiquitin-mediated proteolysis. (Review) PMID: 23182110
    14. After DNA damage, cyclin F is downregulated in an ATR-dependent manner to allow accumulation of RRM2. Defective elimination of cyclin F delays DNA repair and sensitizes cells to DNA damage, a phenotype that is reverted by expressing a nondegradable RRM2 mutant. PMID: 22632967
    15. SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity PMID: 20596027
    16. degradation during G2-M by mechanisms fundamentally different from other cyclins PMID: 12122006

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 蛋白家族：
    Cyclin family, Cyclin AB subfamily
  • 組織特異性：
    Widely expressed, with expression detected in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1591

    OMIM: 600227

    KEGG: hsa:899

    STRING: 9606.ENSP00000380256

    UniGene: Hs.1973



主站蜘蛛池模板： 久久精品国产精品青草| 久久午夜福利电影| 精品一区二区三区无码免费直播| 精品久久久无码中文字幕边打电话| 国产精品无码制服丝袜| 韩国精品一区二区三区四区| 日本人又黄又爽又色的视频| 综合激情五月综合激情五月激情1| 图片区 小说区 区 亚洲五月| 国产又爽又猛又粗的视频a片| 国产成人福利美女观看视频| 琪琪秋霞午夜av影视在线| 精品多人p群无码| 99偷拍视频精品一区二区| 少妇扒开粉嫩小泬视频| 忘忧草社区中文字幕www| 宅男宅女精品国产av天堂| 免费无码久久成人网站入口| 中文字幕精品久久久久人妻红杏1| 婷婷五月深深久久精品| 伊人无码精品久久一区二区| 亚洲欧洲日产国码无码| 狠狠cao日日穞夜夜穞av| 久久精品国产亚洲一区二区| 色多多成视频人在线观看| 成人免费乱码大片a毛片| 国产人妖视频一区二区| 伊人狠狠色丁香婷婷综合| 国产麻豆一精品av一免费软件| 内射女校花一区二区三区| 非洲黑人最猛性xxxx交| 亚洲综合小说另类图片五月天| 超清精品丝袜国产自在线拍| 中国丰满少妇人妻xxx性董鑫洁| 搡8o老女人老妇人老熟| 少妇午夜啪爽嗷嗷叫视频| 人人做人人爽久久久精品| 越南女子杂交内射bbwxz| 亚洲精品成a人在线观看 | 午夜精品久久久久久久爽| 久久亚洲精品中文字幕一区|