在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCL28 Antibody

  • 中文名稱:
    CCL28兔多克隆抗體
  • 貨號:
    CSB-PA868302ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: C-C motif chemokine 28 antibody at 5μg/ml + Mouse spleen tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 15, 13 kDa
      Observed band size: 15 kDa
    • Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA868302ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA868302ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA868302ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CCL28 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    C C motif chemokine ligand 28 antibody; C-C motif chemokine 28 antibody; CC chemokine CCL28 antibody; CCK 1 antibody; CCK1 antibody; CCK1 protein antibody; CCL 28 antibody; CCL28 antibody; CCL28_HUMAN antibody; Chemokine (C-C motif) ligand 28 antibody; chemokine (C-C motif) ligand 28 splice variant chi antibody; MEC antibody; Mucosae associated epithelial chemokine antibody; Mucosae-associated epithelial chemokine antibody; Protein CCK1 antibody; SCYA28 antibody; Small inducible cytokine A28 [Precursor] antibody; small inducible cytokine subfamily A (Cys-Cys); member 28 antibody; Small-inducible cytokine A28 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human C-C motif chemokine 28 protein (20-127AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
  • 基因功能參考文獻:
    1. this review discusses the role of CCL28 in innate and adaptive immunity PMID: 28843907
    2. Results show that CCL28 expression was up-regulated under hypoxic condition in lung adenocarcinoma cells. Besides other effects on tumor biology such as immunosuppression, CCL28 could promote angiogenesis in lung adenocarcinoma by directly activating its receptor, CCR3, on microvascular endothelial cells. PMID: 27250766
    3. our results show for the first time that CCL28 contributes to breast cancer progression through the ERK/MAPKmediated anti-apoptotic and metastatic signaling pathway. Antagonists of CCL28 and the MAPK signaling pathway may be used synergistically to treat breast cancer patients. PMID: 28713975
    4. HCC recruits Tregs to promote angiogenesis under hypoxic condition by upregulating CCL28 expression. These findings establish a link between Tregs and hypoxia in HCC growth and may provide a new potential therapeutic target for treating HCC. PMID: 27716621
    5. CCL28 was absent in saliva of primary Sjogren's syndrome patients. This finding did not correlate with salivary IgA levels. PMID: 25567740
    6. disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE PMID: 26642722
    7. CCL28-CCR3 interactions are involved in the homeostatic trafficking of CD4(+) T cells to the upper airways. PMID: 24917456
    8. High CCL28 gene methylation is associated with gastric tumor aggressiveness. PMID: 25740824
    9. CCL28 is a potent growth-promoting factor with the ability to support the in vitro and in vivo functional properties of cultured human hematopoietic cells. PMID: 23509159
    10. These results indicate a role for IL-17A in the human lung by enhancing the expression of CCL28 and hence driving the recruitment of IgE-secreting B cells. PMID: 21447959
    11. tumour hypoxia promotes the recruitment of regulatory T (T(reg)) cells through induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis PMID: 21753853
    12. CCL28 may play dual roles in mucosal immunity as a chemoattractant for cells expressing CCR10 and/or CCR3 such as plasma cells and also as a broad-spectrum antimicrobial protein secreted into low-salt body fluids. PMID: 12538707
    13. CCR10 and its mucosal epithelial ligand CCL28 have roles in the migration of circulating IgA plasmablasts PMID: 12671049
    14. CCL28 produced by keratinocytes is mediated by different signal pathways from CCL27, and both CCL27 and CCL28 are involved in the pathogenesis of inflammatory skin diseases. PMID: 16433680
    15. CCL28 is one link between microbial insult and the exacerbation of pathologies such as asthma, through an NFkappaB-dependent mechanism PMID: 16581045
    16. Expression of CCL28 by epithelial cells from chronically inflamed liver in response to microbial products or interleukin-1 provides a signal to localize CCR10-expressing regulatory T cells at mucosal surfaces. PMID: 16785557
    17. CCL28 mediates mucosal immunity in HIV exposure and infection PMID: 17912348
    18. These studies are the first to show increased CCL28 production during gastrointestinal infection in humans and provide an explanation for the large influx of IgA-secreting cells to the gastric mucosa in H. pylori-infected individuals. PMID: 18426876
    19. There was a robust migration of specific IgA- and IgM-antibody-secreting cells induced by Salmonella vaccination toward the mucosal chemokines CCL25 and CCL28 PMID: 19003934
    20. data reinforce concept that CCL28 may contribute to the pathogenesis of atopic dermatitis probably through selective migration & infiltration of effector/memory T-helper-2 cells in the skin; CCL28 may represent a prognostic marker for disease severity PMID: 19659860

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine beta (chemokine CC) family
  • 組織特異性:
    Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leu
  • 數據庫鏈接:

    HGNC: 17700

    OMIM: 605240

    KEGG: hsa:56477

    STRING: 9606.ENSP00000354416

    UniGene: Hs.656904



主站蜘蛛池模板: 东京热人妻中文无码av| 国产精品美女被遭强扒开双腿| 九九久久精品无码专区| 人妻有码av中文字幕久久琪| 国产日产欧产美| 欧美成 人版中文字幕| 国产日韩欧美久久久精品图片| 久久九九兔免费精品6| 亚洲精品国产成人无码区a片| 综合自拍亚洲综合图区高清| 朝鲜女人大白屁股ass孕交| 国产日韩在线时看高清视频| 亚洲的天堂av无码| 国产精品被窝福利一区| 免费无码又爽又刺激成人| 69国产成人精品午夜福中文| 亚洲 丝袜 另类 校园 欧美| 玩弄放荡人妻一区二区三区| 亚洲人成电影网站色| 精品久久国产综合婷婷五月| 天堂在线www资源| 午夜福利啪啪片| 无遮挡又黄又刺激的视频| 成年免费视频黄网站在线观看| 欧美黑人巨大videos精品男男| 日韩欧美激情兽交| 国精产品一品二品国精在线观看| 国产精品美女久久久网av| 久久人妻无码中文字幕第一| 日本vs亚洲vs韩国一区三区| 久久99亚洲精品久久频| 精品国产人成亚洲区| 狠狠色噜噜狠狠色综合久| 涩里番网污站| 欧美在线精彩视频免费播放| 亚洲夂夂婷婷色拍ww47| 国内精品伊人久久久久777| 日韩精品一卡2卡三卡4卡| 成人网站精品久久久久| 欧美牲交a欧美牲交aⅴ| 中文字幕丰满乱子伦无码专区|