在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCL27 Antibody

  • 中文名稱:
    CCL27兔多克隆抗體
  • 貨號:
    CSB-PA500478
  • 規格:
    ¥1090
  • 圖片:
    • Western blot analysis of mouse-kidney lysis using CCL27 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:100
    • Western Blot analysis of various cells using Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ALP antibody; C-C motif chemokine 27 antibody; CC chemokine ILC antibody; Ccl27 antibody; CCL27_HUMAN antibody; Chemokine (C-C motif) ligand 27 antibody; CTACK antibody; CTAK antibody; Cutaneous T cell attracting chemokine antibody; Cutaneous T-cell-attracting chemokine antibody; ESkine antibody; IL 11 R alpha locus chemokine antibody; IL-11 R-alpha-locus chemokine antibody; ILC antibody; PESKY antibody; SCYA27 antibody; Skinkine antibody; Small inducible cytokine A27 antibody; small inducible cytokine subfamily A (Cys-Cys); member 27 antibody; Small-inducible cytokine A27 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human CTACK.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.
  • 基因功能參考文獻:
    1. Plasma CCL27 levels were significantly lower in the VCA-IgA-negative normal subjects than in either the VCA-IgA-positive healthy donorsor the NPC patients. PMID: 29295705
    2. CCR10/CCL27 crosstalk mediated drug resistance, contributing to failure of proteasome-inhibitors in multiple myeloma. PMID: 27732933
    3. detected in the nucleus in eczema, cytoplasm in psoriasis PMID: 27193975
    4. CCL27 drives baseline recruitment of Herpes simplex virus-specific CD8 T cells expressing CCR10, while interferon-responsive CXCR3 ligands recruit additional cells in response to virus-driven inflammation. PMID: 28701399
    5. We therefore concluded that the cross talk between TNFa and ROS after keratinocytes was exposed to radiation, triggered CCL27 secretion for subsequent inflammation response. PMID: 27879026
    6. Our study showed that a higher immunostaining of CCL27 in supratumoral epidermis is associated with longer progression-free interval and melanoma-specific survival. PMID: 27325798
    7. Our data supports previous reports showing IL-17 and -23 upregulation in association with Multiple sclerosis and potentially identify a previously unknown involvement for CCL27. PMID: 26295034
    8. NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management. PMID: 25539641
    9. Findings support the notion that CCR10 and its ligand CCL27 may contribute to the skin infiltration of malignant T-cells in mycosis fungoides and adult T-cell leukemia/lymphoma. PMID: 24970722
    10. Our study suggests that CTACK/CCL27 may have a pivotal role in the early stage of psoriasis plaque formation, but should be downregulated in the later stage to induce inflammation characteristic for chronic psoriasis plaques PMID: 24710735
    11. Seventeen mediators were identified in burn wound exudates (concentration range 0.0006-9 ng/mg total protein), including the skin-specific chemokine CCL27. PMID: 23980822
    12. We show that the adult but not prenatal human keratinocytes produce and release large amounts of CCL27. PMID: 24037339
    13. CCL27 chemokine implicates cholesteatoma keratinocytes as contributors in cholesteatoma progression. PMID: 23670528
    14. low CCL27/CCR10 and CXCL12/CXCR4 intratumoral mRNA ratios are associated with melanoma progression PMID: 22526457
    15. Serum concentrations of TARC and CTACK were significantly higher in AD (atopic dermatitis) children than in healthy controls, and correlated with severity of symptoms. PMID: 22017510
    16. IL-1beta-induced CCL27 gene expression in normal human keratinocytes is regulated through the p38 MAPK/MSK1/Mnk1+2 as well as the IKKbeta/NF-kappaB signalling pathways. PMID: 21993219
    17. expression of CCL27 and CCL17 in the inflammatory skin diseases: psoriasis, atopic dermatitis and acute allergic contact dermatitis induced in nickel-sensitive individuals PMID: 21707761
    18. member of cytokine family; a chemokine PMID: 11821893
    19. membrane of cytokine family PMID: 11821900
    20. Serum CTACK levels in patients with atopic dermatitis(AD) and psoriasis vulgaris(pSv) were significantly higher. CTACK was strongly expressed in lesional ke-ratinocytes of patients with AD and PsV. PMID: 12642842
    21. serum levels significantly correlated with disease activity in patients with atopic dermatitis PMID: 14767451
    22. primary Th2-dominated inflammatory reaction in atopic dermatitis induced by TARC leads to an augmented skin-specific inflammatory reaction through CTACK. PMID: 15335355
    23. PSGL-1 interacts with CCL27 (CTACK/ILC/ESkine), a skin-associated chemokine that attracts skin-homing T lymphocytes PMID: 15466853
    24. CCL27 expression is under the control of NF-kappaB, and that NF-kappaB, as indicated by others, may be an attractive target for therapy in inflammatory skin diseases PMID: 15598438
    25. IL-1alpha, TNF-alpha, CCL20, CCL27, and CXCL8 alarm signals are induced in human cells after allergen and irritant exposure PMID: 15679580
    26. CCL28 produced by keratinocytes is mediated by different signal pathways from CCL27, and both CCL27 and CCL28 are involved in the pathogenesis of inflammatory skin diseases. PMID: 16433680
    27. CCR10-CTACK/CCL27 interactions between circulating T cells and keratinocytes would seem to play an important role in the pathophysiology of mycosis fungoides. PMID: 16675558
    28. LTB(4) may enhance TNF-alpha-induced CCL27 production by activating NF-kappaB via the BLT1/G(i/o)/PI3K/ERK pathway in human keratinocytes. PMID: 17581202
    29. Human keratinocyte-derived skin tumors may evade T cell-mediated antitumor immune responses by down-regulating the expression of CCL27 through the activation of epidermal growth factor receptor (EGFR)-Ras-MAPK-signaling pathways. PMID: 18025475
    30. Serum concentrations of CCL17, CCL22, and CCL27 correlate well with the extent and intensity of Atopic dermatitis (AD) in infants. Of the three Th2 chemokines examined, serum CCL27 correlated most significantly with the severity of AD PMID: 18266834
    31. a novel mechanism for the recruitment of CCR10-positive T cells to skin-draining LN following the rapid release of preformed CCL27 from the epidermis PMID: 18453562
    32. Significantly lower serum concentration of CXCL-9, CXCL-10, CCL-17, and IL-18 and higher concentration of CXCL-12 and CCL-27 were found in atopic dermatitis patients under 10 years old when compared to Control. PMID: 19639049

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine beta (chemokine CC) family
  • 組織特異性:
    Testis, thymus, placenta, ovary and skin.
  • 數據庫鏈接:

    HGNC: 10626

    OMIM: 604833

    KEGG: hsa:10850

    STRING: 9606.ENSP00000259631

    UniGene: Hs.648124



主站蜘蛛池模板: 9色国产深夜内射| av无码中文字幕不卡一区二区三区| 久久国产精品人妻丝袜| av无码免费永久在线观看| 国产内射爽爽大片视频社区在线| 国产性夜夜春夜夜爽1a片| 国产精品一区二区在线蜜芽tv| 欧美综合区自拍亚洲综合绿色| 中文有码亚洲制服av片| 人妻少妇heyzo无码专区| 国内精品综合久久久40p| 亚洲aⅴ综合av国产八av| 亚洲国产中文在线二区三区免 | 激情欧美成人久久综合| 久久国产色av免费看| 国产xxxx做受视频| 少妇无码av无码专区线y| 好吊色欧美一区二区三区四区| 亚洲一区 日韩精品 中文字幕 | 日本人妻人人人澡人人爽| 国产人妻久久精品二区三区| 131mm少妇做爰视频| 午夜福利免费0948视频| 人人妻人人澡人人爽久久av| 国产精品无码专区在线观看| 亚洲乱码日产精品bd| 特黄做受又粗又大又硬老头| 欧美人与动人物牲交免费观看久久 | 国产av国片精品一区二区| 1000部夫妻午夜免费| 精品黑人一区二区三区| 国产婷婷亚洲999精品小说| 精品综合久久久久久8888| 欧美自拍嘿咻内射在线观看| 丝袜人妻一区二区三区| 免费人成网站视频在线观看国内 | 国产精品人人做人人爽人人添| 潮喷失禁大喷水无码| 日产欧美国产日韩精品| 国产一区二区三精品久久久无广告| 少妇做爰免费视频网站|