在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCL23 Antibody

  • 中文名稱:
    CCL23兔多克隆抗體
  • 貨號:
    CSB-PA784773
  • 規格:
    ¥2024
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/50.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CCL23 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide corresponding to residues near the C terminal of Human C-C motif chemokine 6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
  • 基因功能參考文獻:
    1. CCL23 is posttranslationally modified by trypsin-like serine proteases and CCL23(47-117) might be a major active form of CCL23 in nasal polyps with chronic rhinosinusitis. PMID: 26560043
    2. The coexistence of diabetes and oxidative stress independently affected CCL23 levels, while the presence of Cardiovascular disease and inflammation had no impact on its concentrations. PMID: 24995525
    3. ADAMTS 8, CCL23, and TNFSF15 are implicated in anti-angiogenic activities PMID: 24384427
    4. Data show CCL23 stimulates chemotaxis of human THP-1 monocytes and enhances release of MMP-2, and suggest it plays a role in atherogenesis. PMID: 21656154
    5. Overproduction of CCL23 in nasal polyps might contribute to the pathogenesis of eosinophilic chronic rhinosinusitis with nasal polyps PMID: 21497884
    6. Patients with systemic sclerosis who had elevated CCL23 levels had shorter disease duration, and a higher frequency of pulmonary arterial hypertension. Serum CCL23 level was increased in early phase of disease and could be a marker for disease activity. PMID: 20824279
    7. Fresh eosinophils contained trace amounts of CCL23 protein. CCL23 was significantly released into the supernatant when the eosinophils were stimulated with GM-CSF or IL-5 but not with IFN-gamma or immobilized sIgA. PMID: 21646793
    8. independently associated with coronary atherosclerosis PMID: 20187767
    9. CKbeta8 transduces the chemotaxis signal through the G(i)/G(o) protein, phospholipase C, protein kinase C delta and NF-kappaB. PMID: 19951712
    10. CCL23 promoted chemotactic migration and differentiation of endothelial cells, and neovascularization in the chick chorioallantoic membrane PMID: 15927850
    11. May play a direct role in angiogenesis via upregulation of matrix metalloproteinase (MMP)-2 expression. PMID: 16378600
    12. Collectively, these data suggest a link between the inducible phenotype of CCL23 expression in monocytes by the prototype Th2 molecule pair IL-4/STAT6 and the increased number of CCL23-expressing cells in skin of atopic dermatitis patients. PMID: 17371990
    13. A peptide ligand termed SHAAGtide is cleaved from CCL23; is itself an attractant of monocytes and neutrophils in vitro; recruits leukocytes in vivo; is more potent than other natural agents with activity for FPRL1; receives authors' designation "CCR12." PMID: 17513790
    14. This protein may participate in the malignant progression of certain human cancer cells that overexpress ErbB2 through the transactivation of ErbB2 tyrosine kinase. PMID: 18258606
    15. CCL23, M-CSF, TNFRSF9, TNF-alpha, and CXCL13 are predictive of rheumatoid arthritis disease activity and may be useful in the definition of disease subphenotypes and in the measurement of response to therapy in clinical studies. PMID: 18668547
    16. these findings suggest that CCL23 results in up-regulation of KDR/flk-1 receptor gene transcription and protein expression and that KDR/Flk-1 up-regulation induced by CCL23 may contribute to potentiation of VEGF action in angiogenesis. PMID: 19265684

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine beta (chemokine CC) family
  • 組織特異性:
    High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CC
  • 數據庫鏈接:

    HGNC: 10622

    OMIM: 602494

    KEGG: hsa:6368

    UniGene: Hs.169191



主站蜘蛛池模板: 一区一区三区产品乱码| 亚洲人成网站18禁止大| 国产v在线最新观看视频| 欧美真人性做爰全过程| 国产尤物精品视频| 在线亚洲日产一区二区| 久久久久国色av∨免费看| 日韩人妻精品无码一区二区三区| 国产成人亚洲综合无码精品| 国产日韩欧美亚欧在线| 亚洲人成网站观看在线播放| 国内精品久久久久影院免费| 成人做爰www网站视频下载| 午夜dj在线观看免费视频| av人摸人人人澡人人超碰小说 | 亚洲精品乱码久久久久久久久久久久| 人妻夜夜爽天天爽三区麻豆av网站| 亚洲精品国产精品国产自2022| 无码视频免费一区二区三区| 免费无码又爽又刺激高潮的视频| 日日摸天天摸爽爽狠狠97| 国产粉嫩小泬在线观看泬| 日韩欧美mv在线观看免费| 无码aⅴ精品一区二区三区浪潮| 无码av天天av天天爽| 老汉色老汉首页a亚洲| 亚洲乱码一区av春药高潮| 亚洲欧洲免费无码| 亚洲亚洲熟妇色l图片20p| 亚洲乱码中文字幕小综合| 婷婷五月小说| 久精品国产欧美亚洲色aⅴ大片| 欧美 在线 成 人怡红院| 极品老师腿张开粉嫩小泬| 阳茎伸入女人阳道视频免费| 先锋人妻无码av电影| 4hu亚洲人成人无码网www电影首页| 少妇扒开粉嫩小泬视频| 亚洲色在线v中文字幕| 永久黄网站色视频免费看| 乱人伦人妻中文字幕无码久久网 |