在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCDC6 Antibody, Biotin conjugated

  • 中文名稱:
    CCDC6兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA623068LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CCDC6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CCDC 6 antibody; CCDC6 antibody; CCDC6_HUMAN antibody; Coiled coil domain containing 6 antibody; Coiled coil domain containing protein 6 antibody; Coiled-coil domain-containing protein 6 antibody; D10S170 antibody; FLJ32286 antibody; H4 antibody; Papillary thyroid carcinoma encoded protein antibody; Papillary thyroid carcinoma-encoded protein antibody; Protein H4 antibody; PTC antibody; TPC antibody; TST 1 antibody; TST1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Coiled-coil domain-containing protein 6 protein (347-440AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. FGFR inhibitors, particularly BGJ398, are therapeutic options for cholangiocarcinoma patients harboring FGFR2-CCDC6 fusions. PMID: 27216979
    2. Our findings nevertheless suggest that CCDC6-RET fusions identified by multiplex testing are potential targets for nintedanib therapy. PMID: 26787234
    3. we propose that the amount of CCDC6 protein in primary tumors, as reported in lung, may depend on the impairment of the CCDC6 turnover due to altered protein-protein interaction and post-translational modifications PMID: 25885523
    4. Results show that RNA-binding protein EWS binds and regulates CCDC6 expression at RNA and protein levels. PMID: 25751255
    5. CCDC6 levels provide valuable insight for OS. PMID: 25302833
    6. the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth. PMID: 24059746
    7. Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing. PMID: 23578175
    8. CCDC6 is associated with cAMP signaling by fine regulating CREB1 transcriptional activity in normal and transformed thyroid cells. PMID: 23145146
    9. CCDC6-RET fusion is associated with lung adenocarcinoma. PMID: 23154560
    10. It was shown that FBXW7 interacts with and targets CCDC6 for ubiquitin-mediated proteasomal degradation. FBXW7-mediated CCDC6 degradation was impaired in response to DNA damage. PMID: 23108047
    11. Following genotoxic stress, loss or inactivation of CCDC6 in cancers that carry the CCDC6 fusion, accelerates the dephosphorylation of pH2AX S139, resulting in defective G2 arrest and premature mitotic entry. PMID: 22655027
    12. CCDC6 plays a key role in cell cycle control. PMID: 22363533
    13. we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas PMID: 22327623
    14. down-regulation of 14-3-3sigma in the absence of CCDC6 demonstrated their direct association and supports the notion that CCDC6 contributes to cancer development, possibly through malignant pathways involving 14-3-3sigma PMID: 22399611
    15. repression of CREB1 activity by CCDC6 has a critical function in the development of human thyroid papillary carcinomas carrying RET/PTC1 activation. PMID: 20498639
    16. H4(D10S170) is involved in the cellular response to ataxia telangectasia mutated (ATM) kinase; impairment of H4(D10S170) gene function might have a role in thyroid carcinogenesis. PMID: 17420723
    17. frequency of the occurrence of BRAF mutation and/or RET/PTC in H4-PTEN positive tumors was extremely high (75%) in papillary thyroid carcinoma PMID: 18226854
    18. PTC1 and PTC3 are highly oncogenic proteins when overexpressed, but result in indolent disease compared with RET-related MTCs due to their relatively low expression from the NCOA4 and CCDC6 promoters in vivo. PMID: 19487296

    顯示更多

    收起更多

  • 相關(guān)疾病:
    A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
  • 亞細(xì)胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton. Note=May be a cytoskeletal protein.
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 18782

    OMIM: 601985

    KEGG: hsa:8030

    STRING: 9606.ENSP00000263102

    UniGene: Hs.591360



主站蜘蛛池模板: 色拍拍在线精品视频| 丰满岳妇乱一区二区三区| 久久av高清无码| 久久发布国产伦子伦精品| 精品国产av无码一区二区三区| 色欲精品国产一区二区三区av| 最新69国产成人精品视频| 亚洲男人a在天堂线一区| 久久婷婷成人综合色综合| 免费萌白酱国产一区二区三区| 成年午夜精品久久久精品| 国产日产欧产美韩系列麻豆| 中文午夜人妻无码看片| 欧美丰满熟妇xxxx性ppx人交 | 午夜片神马影院福利| 国产视频亚洲精品视频| 最新国产麻豆aⅴ精品无码| 国产综合无码一区二区色蜜蜜| 亚洲精品一区二区三区新线路| 热久久99这里有精品综合久久| 正在播放国产剧情亂倫| 亚州av综合色区无码一区| 无码人妻丰满熟妇区毛片| 国产精品久久久久久日本| 国产色a在线观看| 欧美亚洲国产精品久久高清| 中文无码字幕中文有码字幕| 国产色诱视频在线播放网站| 国自产偷精品不卡在线| 国产av精国产传媒| 国模无码一区二区三区不卡| 亚洲日韩亚洲另类| 精品国产制服丝袜高跟| 日日噜噜夜夜狠狠久久蜜桃| 国产精品aⅴ在线观看| 亚洲熟妇丰满大屁股熟妇| 久久婷婷五月综合色丁香| 人人爽人人爽人人片av东京热| 欧美人与动性xxxxx交性| 中国女人内谢69xxxx视频| 偷偷要色偷偷中文无码|