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  4. CCDC50 Antibody

CCDC50 Antibody

  • 中文名稱：
    CCDC50兔多克隆抗體
  • 貨號：
    CSB-PA004709GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CCDC50
  • 別名：
    C3orf6 antibody; C3orf6 YMER antibody; CCD50_HUMAN antibody; CCDC 50 antibody; Ccdc50 antibody; Chromosome 3 open reading frame 6 antibody; Coiled coil domain containing 50 antibody; Coiled coil domain containing protein 50 antibody; Coiled-coil domain-containing protein 50 antibody; Protein Ymer antibody; Ymer antibody; Ymer protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CCDC50
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in EGFR signaling.
  • 基因功能參考文獻：
    1. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. [review] PMID: 27142990
    2. Ymer acts as a regulator downstream of several receptors and that Ymer functions as a positive or negative regulator in a signaling pathway-dependent manner. PMID: 22331027
    3. identification of a novel DFNA locus on chromosome 3q28-29 in a Spanish family with postlingual and progressive hearing loss[DFNA44] PMID: 12483295
    4. Ymer functions as a novel inhibitor for the down-regulation of the EGF receptor and plays a crucial role for regulating the amount of the EGF receptor on the cell surface membrane PMID: 16803894
    5. These findings demonstrate that Ymer is likely to be a negative regulator for the NF-kappaB signaling pathway. PMID: 19059208
    6. CCDC50 is required for survival in mantle cell lymphoma and chronic lymphocytic leukemia cells and controls NFkappaB signaling PMID: 19641524

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  • 相關疾病：
    Deafness, autosomal dominant, 44 (DFNA44)
  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Isoform 1 and isoform 2 are coexpressed in placenta, liver, lung, kidney and pancreas. Only isoform 1 is detected in skeletal muscle, brain and heart.
  • 數據庫鏈接：

    HGNC: 18111

    OMIM: 607453

    KEGG: hsa:152137

    UniGene: Hs.478682



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