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  4. CCDC134 Antibody

CCDC134 Antibody

  • 中文名稱：
    CCDC134兔多克隆抗體
  • 貨號：
    CSB-PA863989EA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA863989EA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA863989EA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CCDC134 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CCDC134
  • 別名：
    CC134_HUMAN antibody; ccdc134 antibody; coiled-coil domain containing 134 antibody; Coiled-coil domain-containing protein 134 antibody; dJ821D11.3 antibody; FLJ22349 antibody; MGC21013 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Coiled-coil domain-containing protein 134 protein (23-229AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CCDC134 Antibody (CSB-PA863989EA01HU)，的標記方式是Non-conjugated。對于CCDC134 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA863989EB01HU CCDC134 Antibody, HRP conjugated ELISA
    FITC CSB-PA863989EC01HU CCDC134 Antibody, FITC conjugated
    Biotin CSB-PA863989ED01HU CCDC134 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling.; In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
  • 基因功能參考文獻：
    1. CCDC134 may also act as a novel regulator of human alteration/deficiency in activation 2a, and be involved in the p300-CBP-associated factor complex and affect its acetyltransferase activity PMID: 29115376
    2. CCDC134 promotes cell proliferation through the JAK3-STAT5 pathway. PMID: 25125657
    3. The attenuated expression of CCDC134 promoted the activation of Erk1/2 and JNK/SAPK, but had no effect on p38 in gastric cancer. PMID: 23070808
    4. CCDC134 might act as a novel regulator of hADA2a, and plays roles in the PCAF complex via hADA2a to affect its acetyltransferase activity and UV-induced DNA damage repair. PMID: 22644376
    5. These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways. PMID: 18087676

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum.
  • 蛋白家族：
    CCDC134 family
  • 組織特異性：
    Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level). Also detected in placenta. Highest expression in
  • 數據庫鏈接：

    HGNC: 26185

    KEGG: hsa:79879

    STRING: 9606.ENSP00000255784

    UniGene: Hs.474991



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