在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CC2D1A Antibody

  • 中文名稱:
    CC2D1A兔多克隆抗體
  • 貨號:
    CSB-PA004608GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CC2D1A
  • 別名:
    CC2D1A antibody; AKI1Coiled-coil and C2 domain-containing protein 1A antibody; Akt kinase-interacting protein 1 antibody; Five prime repressor element under dual repression-binding protein 1 antibody; FRE under dual repression-binding protein 1 antibody; Freud-1 antibody; Putative NF-kappa-B-activating protein 023N antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CC2D1A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
  • 基因功能參考文獻:
    1. Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different PMID: 26782176
    2. CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR and TLR4. PMID: 27769858
    3. Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1. Aki1 regulates CREB by modulating protein kinase A activity. The Aki1-CREB axis plays an important role in DMM pathogenesis. PMID: 26294214
    4. Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD, and seizures. CC2D1A regulates NF-kappaB signaling. PMID: 25066123
    5. All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt and increased the phosphorylation of cleaved PARP. PMID: 25036909
    6. Non-genomic downregulation of 5-HT1A receptor by 17betaestradiol does not involve NUDR and Freud-1 proteins. PMID: 22328058
    7. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity PMID: 22833682
    8. CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex. PMID: 22406677
    9. CC2D1A interaction with CHMP4B/4A blocks HIV-1 budding. PMID: 22258254
    10. Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective. PMID: 22023432
    11. Reductions in Freud-1 expression in prefrontal cortex may be associated with early onset of major depressive disorder. PMID: 20392296
    12. Data suggest that the anti-tumor activity of NF-kappaB inhibitors is associated with p53-mediated activation of autophagy. PMID: 21274377
    13. central role for TAPE (CC2D1A/Freud-1/Aki-1)in linking TLR3 and TLR4 to innate immune defenses at an early step PMID: 21189260
    14. CC2D1A activates NF-kappaB through the canonical IKK pathway PMID: 20529849
    15. these results indicate that cyclin B1-Cdk1 is a kinase of Aki1 during mitosis and that its phosphorylation of Aki1 may regulate mitotic function. PMID: 20171170
    16. Centrosome-associated Aki1 and cohesin play pivotal roles in preventing premature cleavage in centriole cohesion. PMID: 19948489
    17. A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive mental retardation. PMID: 16033914
    18. a deletion in the CC2D1A gene has been linked to nonsyndromic mental retardation. This deletion results in the truncation of the helix-loop-helix DNA binding and the C2 domains. PMID: 17394259
    19. Freud-1 has a key role in regulating DRD2 expression PMID: 17535813
    20. disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation PMID: 17714190
    21. Results suggest that Freud-1/Aki1 is a novel receptor-selective scaffold protein for the PDK1/Akt pathway and present a new activation mechanism of Akt. PMID: 18662999
    22. Aki1 (Akt kinase-interacting protein 1)/CC2D1A/Freud-1 localized in centrosomes in addition to cytosol and in nucleus. Aki1 interacts with cohesin to prevent premature separase-mediated centriole disengagement. PMID: 19948489
    23. CC2D1A associated with epidermal growth factor receptor (EGFR) in response to EGF stimulation, and was required for Akt activation induced by EGF, but not by insulin-like growth factor 1 (IGF-1). PMID: 18662999
    24. Paper describes a function of Cc2d1a/Cc2d1b and their Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking. PMID: 17084358
    25. Review of Freud-1 as a repressor of serotonin 1A receptor gene. PMID: 15534042
    26. Freud-1 mediates HDAC-independent repression of the 5-HT1A receptor promoter in neuronal 5-HT1A-positive cells. PMID: 14756806

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, autosomal recessive 3 (MRT3)
  • 亞細胞定位:
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    CC2D1 family
  • 數據庫鏈接:

    HGNC: 30237

    OMIM: 608443

    KEGG: hsa:54862

    STRING: 9606.ENSP00000313601

    UniGene: Hs.269592



主站蜘蛛池模板: 国产av亚洲精品ai换脸电影| 人妻巨大乳一二三区| 午夜dj在线观看免费视频| 天天噜噜噜在线视频| 日本熟妇色一本在线观看| 忘忧草社区在线资源www| 国产精品无码v在线观看| av免费网址在线观看| 亚洲国产精品成人一区二区在线| 色综合欧美亚洲国产| 无人去码一码二码三码区| 天天做天天爱夜夜爽毛片毛片| 韩国理伦片一区二区三区在线播放| 日本丰满熟妇videossex| 极品少妇扒开粉嫩小泬视频| 国产精品门事件av| 国精产品一区一区三区mba下载| 男人扒女人添高潮视频| 免费观看啪啪黄的网站| 亚洲aⅴ天堂av天堂无码app| 狠狠躁天天躁无码中文字幕| 国产精品无码一区二区三区电影 | 久久精品人成免费| 少妇愉情理伦片bd| 久久国产精品偷| 综合激情久久综合激情| 国产精品亚洲一区二区z| 国产精品va无码一区二区| 乱中年女人伦av一区二区| 女人被躁到高潮免费视频软件| 狠狠色狠狠色综合日日五| 五月花成人网| 日日做夜狠狠爱欧美黑人| 亚洲性夜色噜噜噜在线观看不卡 | 又色又爽又黄的美女裸体网站| 欧美日韩亚洲国内综合网| 国产成人亚洲精品| 成人影院yy111111在线 | 一色屋精品视频在线观看| 亚洲午夜无码极品久久| 色欲综合久久中文字幕网|