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CBX2 Antibody

  • 中文名稱:
    CBX2兔多克隆抗體
  • 貨號:
    CSB-PA070046
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CBX2
  • 別名:
    Cbx 2 antibody; CBX2 antibody; CBX2_HUMAN antibody; CDC A6 antibody; CDCA6 antibody; Cell division cycle associated 6 antibody; Cell division cycle associated6 antibody; chromobox homolog 2 (Pc class homolog, Drosophila) antibody; Chromobox homolog 2 antibody; Chromobox homolog2 antibody; Chromobox protein homolog 2 antibody; hromobox homolog 2 antibody; M33 antibody; M33 polycomb like antibody; MOD 2 antibody; MOD2 antibody; Modifier 3 antibody; Modifier3 antibody; Pc class homolog antibody; Polycomb antibody; SRXY5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human CBX2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.
  • 基因功能參考文獻:
    1. study indicates a distinct function of the shorter form of CBX2 and by identifying several of its unique targets, can advance our understanding of DSD pathogenesis and ultimately DSD diagnosis and management. PMID: 29998616
    2. These results suggest that CBX2's phosphorylation is critical for its transcriptional repression of target genes. PMID: 28992316
    3. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax-group genes and it overexpressed polycomb genes EZH2 and CBX2. PMID: 26431491
    4. up-regulated in metastatic castration-resistant prostate cancer and elevated expression correlates with poor clinical outcome PMID: 26877821
    5. CBX2 role in the sex development cascade is to stimulate the male pathway and concurrently inhibit the female pathway. PMID: 25569159
    6. CBX2 upregulation and amplification significantly correlated with metastatic progression and lower overall survival in many cancer types, particularly those of the breast PMID: 25225902
    7. This study does not support CBX2 gene disruption as a common cause of gonadal gonadal disorders of sex development. PMID: 23219007
    8. Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 protein complex. PMID: 22419124
    9. CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin PMID: 22009739
    10. hPc2 serves as a SUMO E3 ligase for cystathionine beta-synthase, increasing the efficiency of sumoylation. PMID: 19107218

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  • 相關疾病:
    46,XY sex reversal 5 (SRXY5)
  • 亞細胞定位:
    Nucleus. Chromosome.
  • 數據庫鏈接:

    HGNC: 1552

    OMIM: 602770

    KEGG: hsa:84733

    STRING: 9606.ENSP00000308750

    UniGene: Hs.368410



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