在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CBX1 Antibody

  • 中文名稱:
    CBX1兔多克隆抗體
  • 貨號:
    CSB-PA712321
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA712321(CBX1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CBX1
  • 別名:
    CBX 1 antibody; CBX antibody; Cbx1 antibody; CBX1_HUMAN antibody; Chromobox 1 antibody; Chromobox homolog 1 (HP1 beta homolog Drosophila ) antibody; chromobox homolog 1 antibody; Chromobox protein homolog 1 antibody; Drosophila HP1 beta antibody; Heterochromatin protein 1 beta antibody; Heterochromatin protein 1 homolog beta antibody; Heterochromatin protein p25 antibody; heterochromatin protein p25 beta antibody; HP1 beta antibody; HP1 beta homolog antibody; HP1 beta homolog Drosophila antibody; HP1; Drosophila. homolog of; beta antibody; HP1beta antibody; HP1Hs beta antibody; HP1Hsbeta antibody; Human heterochromatin protein p25 mRNA complete cds antibody; M31 antibody; MOD 1 antibody; MOD1 antibody; Modifier 1 protein antibody; p25beta antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human CBX1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
  • 基因功能參考文獻:
    1. the prolyl residue of the PXXVXL motif appears to play a role distinct from that of Pro in the known HP1beta CSD-PXVXL complexes. PMID: 28223359
    2. Data show that heterochromatin protein 1-beta (HP1beta) is a prototypic HP1 protein exemplifying most basal chromatin binding and effects. PMID: 27090491
    3. increased HP1beta expression is associated with the poor prognosis in breast cancer PMID: 25769025
    4. In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions. PMID: 24793759
    5. Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively. PMID: 24840329
    6. Phosphorylation at Ser89 and Ser175 results in localized conformational changes in HP1beta that do not compromise the ability of the protein to bind chromatin. PMID: 24561199
    7. HP1 isoforms distinctly augment AR signaling and cell growth in prostate cancer. Therefore, silencing of HP1beta and HP1gamma may be a promising therapeutic strategy for treatment of prostate cancer. PMID: 23536649
    8. The structural plasticity of HP1beta supports its ability to bind and connect a wide variety of binding partners in epigenetic processes. PMID: 23585859
    9. HP1beta which is associated with PCNA in regions of DNA repair, is bound and does not exchange with the mobile pool, suggesting that HP1beta in association with PCNA may be a component of a DNA repair complex. PMID: 23337132
    10. The HP1beta interactome is enriched with Lys methylated proteins.Role of HP1beta in DNA damage response. PMID: 23707759
    11. study finds that while HP1apha and beta stimulate homologous recombination and single-strand annealing, HP1gamma has an inhibitory role PMID: 23287531
    12. Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1beta with the nucleosome PMID: 22815475
    13. HP1 beta and PCNA, a key player in DNA replication, are closely spaced components of a multiprotein complex involved in replication, both in S phase and during DNA repair, and that the functional complex requires formation of an HP1 dimer. PMID: 22617335
    14. Abrogating GRP/GRPR signaling specifically down-regulates HP1(Hsbeta) expression and inhibiting GRPR signaling, or ablating HP1(Hsbeta) expression, increases colon cancer cell invasiveness in vitro. PMID: 21281799
    15. HP1beta is involved in the proliferation of AR-expressing prostate cancer cells and progression to CRPC as an AR coactivator. PMID: 20308360
    16. Isoform-specific interaction of HP1 with human TAFII130. PMID: 11959914
    17. Gene regulation by human orthologs of Drosophila heterochromatin protein 1. PMID: 12054505
    18. the chromodomain and the chromoshadow domain of HP1 are both required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin PMID: 12560555
    19. cells are exquisitely sensitive to the amount of HP1(Hsalpha) or HP1(Hsbeta) present, as their overexpression influences telomere stability, population doubling time, radioresistance, and tumorigenicity PMID: 14585993
    20. HP1beta recruits endogenous HP1alpha to the chromatin and this induces heterochromatin formation and enhanced histone lysine methylation. PMID: 15899859
    21. analysis of methylation-independent binding to histone H3 and cell cycle-dependent incorporation of HP1beta into heterochromatin PMID: 16547356
    22. HP1 binding as analyzed through the crystal structure of the HP1-EMSY complex PMID: 16615912
    23. Overexpression of HP1-BETA in eye imaginal discs caused abnormally patterned eyes, with reduced numbers of ommatidia. PMID: 17575412
    24. HP1 recruitment-release is a sequential mechanism that is precisely regulated and highly dependent on transcription. PMID: 18239689
    25. findings reveal an unrecognized signalling cascade that helps to initiate the DNA damage response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code itself PMID: 18438399
    26. when HP1beta was co-expressed with TIF1beta/S473A, but not TIF1beta/S473E, the colocalization of TIF1beta/S473A and HP1beta to the promoters of Cdc2 and Cdc25A was enhanced. PMID: 18590578
    27. a nonconventional interaction between HP1 and a tissue-specific transcription factor, MyoD. In addition, they strongly suggest that HP1 isoforms play important roles during muscle terminal differentiation in an isoform-dependent manner. PMID: 18599480

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Unassociated with chromosomes during mitosis.
  • 組織特異性:
    Expressed in all adult and embryonic tissues.
  • 數據庫鏈接:

    HGNC: 1551

    OMIM: 604511

    KEGG: hsa:10951

    STRING: 9606.ENSP00000225603

    UniGene: Hs.77254



主站蜘蛛池模板: 日射精情感性色视频| 中文字幕人成乱码熟女app| 久久96国产精品久久久| 五月婷婷之综合缴情| 国产成人av在线影院无毒| 99久久久精品免费观看国产| 中国凸偷窥xxxx自由视频妇科| 99热99这里只有高清国产| 制服丝袜亚洲中文欧美在线| 九九热爱视频精品视频| 久久伊人色av天堂九九| 亚州中文字幕无码中文字幕 | 欧美va天堂在线电影| 亚洲国产精品久久人人爱| 中文人妻熟妇乱又伦精品| 久久精品国产2020| 亚洲色欲色欲www| 久久精品女人天堂av麻| 东京热无码一区二区三区av| 在线播放国产精品三级| 夜鲁鲁鲁夜夜综合视频欧美| 亚洲日韩av片在线观看| 大ji巴好深好爽又大又粗视频| 欧美自拍亚洲综合图区| 久久久久久亚洲精品| 国产精品人人妻人人爽| 女人夜夜春高潮爽a∨片传媒| 成人一区二区免费视频| 国产精品天干天干综合网| 国产午夜精品一区二区三区老| 午夜精品影视国产一区在线麻豆| 人人妻人人澡人人爽久久av| 日韩精品乱码av一区二区 | 动漫精品中文无码卡通动漫| 亚洲a∨无码无在线观看| 特黄 做受又硬又粗又大视频| 精品国产v无码大片在线观看 | 又大又粗又长的高潮视频| 国产精品久久久久9999爆乳| 欧洲精品欧美精品| 国产成av人片久青草影院|