在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CBLIF Antibody, Biotin conjugated

  • 中文名稱:
    CBLIF兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA009417LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GIF Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GIF
  • 別名:
    CBLIF antibody; GIF antibody; IFMH antibody; Cobalamin binding intrinsic factor antibody; Gastric intrinsic factor antibody; Intrinsic factor antibody; IF antibody; INF antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Cobalamin binding intrinsic factor protein (19-417AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
  • 基因功能參考文獻(xiàn):
    1. the present findings reveal that High-altitude polycythemia -induced gastric mucosal lesion inspires the protection responses by up-regulating APOA4 and APOC3, and down-regulating GIF. PMID: 26485402
    2. Our genetic screening of 154 families of patients with inherited cobalamin malabsorption revealed population-specific mutations, mutational hotspots, and functionally distinct regions in the three causal genes: CUBN, AMN, and GIF. PMID: 22929189
    3. Acute lymphoblastic leukemia and vitamin B12 deficiency secondary to a gastric intrinsic factor gene mutation PMID: 22556038
    4. crystal structure of the complex between IF-Cbl and the cubilin IF-Cbl-binding-region (CUB(5-8)) determined at 3.3 A resolution PMID: 20237569
    5. A polymorphism in the gastric intrinsic factor gene is associated with congenital intrinsic factor deficiency. PMID: 14695536
    6. The parameters obtained for ligand and receptor binding in this study indicate that both full-length 50-kDA intrinsic factor and its 30-kDa and 20-kDa fragments may be involved in assimilation of cobalamin. PMID: 15736970
    7. possible basis for the lack of interchangeability of human and rat IF receptors is presented PMID: 17954916
    8. The Q5R mutation of the intrinsic factor gene predisposes to adult-onset pernicious anemia & other causes of low vitamin B12. In this mutation, intrinsic factor secretion is preserved but B12 absorption may be impaired. PMID: 18338170
    9. a specific GIF mutation to be responsible for all Juvenile cobalamin deficiency cases of West-African origin so far was identified PMID: 19036097

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Hereditary intrinsic factor deficiency (IFD)
  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Eukaryotic cobalamin transport proteins family
  • 組織特異性:
    Gastric mucosa.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4268

    OMIM: 261000

    KEGG: hsa:2694

    STRING: 9606.ENSP00000257248

    UniGene: Hs.110014



主站蜘蛛池模板: 久久婷婷五月综合色丁香| 亚洲精品入口一区二区乱麻豆精品 | 亚洲色欲色欲www在线丝| 一区二区三区在线 | 欧| 蜜臀av综合网| 亚洲欧美日韩另类丝袜一区| 中文字幕日韩人妻在线视频| 少妇一边呻吟一边说使劲视频 | 国内揄拍国产精品人妻门事件| 国产精品国产三级国av| 亚洲va欧美va国产va综合| av小次郎收藏| 精品一区二区三区免费播放| 伊人久久大香线蕉午夜av| 国产三级视频在线播放线观看 | 欧美日韩在线视频| 久久久中文字幕日本无吗| 欧洲精品无码一区二区三区在线播放| 中文无码日韩欧av影视| 18禁免费无码无遮挡不卡网站| 精品一区二区ww| 美女粉嫩饱满的一线天mp4| 久久99精品国产99久久6不卡| 黑人巨大精品欧美黑寡妇| 久久综合99re88久久爱| 亚洲国产欧美日韩精品一区二区三区| 国产小屁孩cao大人免费| 久久久久久综合网天天| 丰满护士巨好爽好大乳| 亚洲热妇无码av在线播放| 国产亚州精品女人久久久久久| av无码一区二区大桥久未| 综合欧美亚洲日本一区| 丰满熟妇人妻av无码区| 欧美一区二区三区激情 | 亚洲精品无码久久| 国产成人亚洲精品| 狠狠色噜噜狠狠狠8888在| 精品国产一区二区三区久久久狼 | 97精品免费公开在线视频| 国内自拍久久久久影院|