在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CASQ1 Antibody

  • 中文名稱:
    CASQ1兔多克隆抗體
  • 貨號:
    CSB-PA004556LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: CASQ1 antibody at 5µg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 46 kDa
      Observed band size: 46 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA004556LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA004556LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CASQ1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CASQ1
  • 別名:
    Calmitin antibody; Calmitine antibody; Calsequestrin 1 (fast twitch; skeletal muscle) antibody; Calsequestrin antibody; Calsequestrin; cell antibody; Calsequestrin; skeletal muscle isoform antibody; Calsequestrin-1 antibody; CASQ antibody; Casq1 antibody; CASQ1_HUMAN antibody; PDIB1 antibody; skeletal muscle isoform antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Calsequestrin-1 protein (127-396AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,CASQ1 Antibody (CSB-PA004556LA01HU),的標(biāo)記方式是Non-conjugated。對于CASQ1 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA004556LB01HU CASQ1 Antibody, HRP conjugated ELISA
    FITC CSB-PA004556LC01HU CASQ1 Antibody, FITC conjugated
    Biotin CSB-PA004556LD01HU CASQ1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity.
  • 基因功能參考文獻:
    1. These results widen the spectrum of skeletal muscle diseases associated with CASQ1 and indicate that these mutations affect properties critical for correct Ca(2+) handling in skeletal muscle fibers. PMID: 28895244
    2. the p.D244G variant in CASQ1 is associated with a skeletal muscle disease and alters sarcoplasmic calcium release PMID: 27196359
    3. Calsequestrin-1 monomers suppress Store-Operated Ca2+ Entry by interacting with STIM1 and attenuating STIM1 aggregation via its C-terminal amino acid 362-396. PMID: 27185316
    4. the protein aggregate myopathy with benign evolution and muscle inclusions composed of excess CASQ1 due to the D244G heterozygous missense mutation in the CASQ1 gene PMID: 26136523
    5. Equilibrium dialysis and turbidity measurements showed that D244G and, to a lesser extent, M87T partially lose Ca(2+) binding exhibited by wild type calsequestrin 1 at high Ca(2+) concentrations. PMID: 26416891
    6. Missense mutation in CASQ1 gene causes the formation of abnormal sarcoplasmic reticulum (SR) vacuoles containing aggregates of CASQ1 results in altered Ca2+ release, and vacuolar myopathy patients phenotype. PMID: 25116801
    7. There is a significant association between SNP A175G and heat stroke. PMID: 24887214
    8. The sarcoplasmic reticulum calcium content in human type II fibres is primarily determined by the CSQ1 abundance, and in type I fibres, by the combined amounts of both CSQ1 and CSQ2. PMID: 24127619
    9. a direct interaction of dysferlin with Trim72/MG53, AHNAK, cytoplasmic dynein, myomesin-2 and calsequestrin-1, but not with caveolin-3 or dystrophin, is reported. PMID: 23792176
    10. CASQ1 is not a major malignant hyperthermia susceptibility locus in the North American population PMID: 23460944
    11. Downregulation of CSQ-1 in diabetic platelets and impairment of CSQ-1 in normal cells leads to disturbed Ca(2+) release, demonstrating a potential role for CSQ-1 in the regulation of the platelet Ca(2+) release process PMID: 22060633
    12. a mechanism for the observed in vitro and in vivo dynamic high-capacity and low-affinity Ca(2+)-binding activity of calsequestrin PMID: 22337878
    13. Single nucleotide polymorphisms within CASQ1 were genotyped in Amish subjects with type 2 diabetes, glucose intolerance and normals. PMID: 15561962
    14. Noncoding single nucleotide polymorphisms in CASQ1 alter diabetes susceptibility, either by a direct effect on CASQ1 gene expression or perhaps by regulating a nearby gene. PMID: 15561963
    15. CASQ1 polymorphism is not associated with type 2 diabetes PMID: 17681849

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Myopathy, vacuolar, with CASQ1 aggregates (VMCQA); Myopathy, tubular aggregate, 1 (TAM1)
  • 亞細胞定位:
    Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix.
  • 蛋白家族:
    Calsequestrin family
  • 組織特異性:
    Expressed in myoblasts (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1512

    OMIM: 114250

    KEGG: hsa:844

    STRING: 9606.ENSP00000357057

    UniGene: Hs.632476



主站蜘蛛池模板: 免费看成人aa片无码视频吃奶| 欧美国产精品日韩在线| 看曰本女人大战黑人视频| 无码人妻丰满熟妇精品区| 亚洲 综合 校园 欧美 制服 | 国产jk白丝在线观看免费| 熟妇人妻无码中文字幕| 亚洲国产精品无码一线岛国| 久久www香蕉免费人成| 亚洲成av人片在线观看天堂无| 蜜臀久久99精品久久久久久小说| 国产真人做爰视频免费| 成人国产一区二区三区| 亚洲乱亚洲乱妇24p| av无码av无码专区| 多人伦交性欧美| 巨胸爆乳美女露双奶头挤奶| 精品人妻码一区二区三区| 亚洲精品国产成人一区二区| 国产精品真实灌醉女在线播放| 亚洲精品无码av中文字幕| 内射极品少妇xxxxxhd| 久久精品欧美日韩精品| 新区乱码无人区二精东| 久久99精品久久久久久hb亚瑟| 国产伦久视频免费观看视频| 性生交大全免费看| 亚洲中文字幕丝祙制服| 亚洲精品无码精品mv在线观看| 国产激情一区二区三区| 巨爆乳无码视频在线观看| 一边捏奶头一边啪高潮视频 | 无码视频免费一区二区三区| 国产精品盗摄!偷窥盗摄| 熟妇熟女乱妇乱女网站| 亚洲国产精品成人影片久久| 无码人妻h动漫| 中字幕人妻一区二区三区| 国产精品久久国产精品99盘| 精品美女国产互换人妻| 国产午夜亚洲精品国产成人小说|