在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CASK Antibody

  • 中文名稱:
    CASK兔多克隆抗體
  • 貨號:
    CSB-PA004539LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA004539LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA004539LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CASK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CAGH39 antibody; Caki antibody; Calcium/calmodulin dependent serine protein kinase antibody; Calcium/calmodulin dependent serine protein kinase (MAGUK family) antibody; Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase antibody; Calcium/calmodulin-dependent serine protein kinase antibody; CAMGUK antibody; CAMGUK protein antibody; CAMGUK; drosophila; homolog of antibody; casK antibody; CMG antibody; CSKP_HUMAN antibody; DXPri1 antibody; DXRib1 antibody; FGS4 antibody; FLJ22219 antibody; FLJ31914 antibody; hCASK antibody; LIN 2 antibody; Lin 2 homolog antibody; LIN2 antibody; Lin2 homolog antibody; MICPCH antibody; MRXSNA antibody; Pals3 antibody; Peripheral plasma membrane protein CASK antibody; Protein lin-2 homolog antibody; TNRC8 antibody; Trinucleotide repeat containing 8 antibody; Vertebtate LIN2 homolog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Peripheral plasma membrane protein CASK protein (470-760AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,CASK Antibody (CSB-PA004539LA01HU),的標記方式是Non-conjugated。對于CASK Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA004539LB01HU CASK Antibody, HRP conjugated ELISA
    FITC CSB-PA004539LC01HU CASK Antibody, FITC conjugated
    Biotin CSB-PA004539LD01HU CASK Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
  • 基因功能參考文獻:
    1. Data suggest that children with heterozygous mutation in the gene CASK kinase (CASK) and mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) are responsive to intensive therapy aimed at increasing functional skills/independence. PMID: 29258560
    2. Authors have identified mutations in PAK3, CASK, and MECP2 that likely contribute to intellectual disability, and the findings extend the spectrum of mutations and phenotypes associated with X-linked intellectual disability. PMID: 28481730
    3. The CASK as a novel regulator of Cav1.2 via a modulation of the voltage-gated calcium channel Cav1.2 open probability. PMID: 27720444
    4. findings demonstrate that microcephaly with pontine and cerebellar hypoplasia (MICPCH) is a genetically heterogeneous condition, in which CASK inactivating mutations appear to account for the majority of MICPCH cases and with severer phenotypes, while the non-CASK mutation cases tend to have milder microcephaly PMID: 28783747
    5. we provide a further characterization of genotype-phenotype correlations in CASK mutations and the presentation of nystagmus and the FGS4 phenotype. PMID: 28139025
    6. During atrial dilation/remodeling, CASK expression was reduced but its localization remained unchanged. PMID: 27364017
    7. we report a patient presenting with a complex phenotype consisting of severe, adult-onset, dilated cardiomyopathy, hearing loss and developmental delay, in which exome sequencing revealed two genetic variants that are inherited from a healthy mother: a novel missense variant in the CASK gene, mutations in which cause a spectrum of neurocognitive manifestations PMID: 27173948
    8. In clinical specimens, CASK was over-expressed in tumors and H. pylori positive tissues, and its mRNA levels were inversely correlated with miR-203 expression. PMID: 25373785
    9. Data indicate that patients with low calcium/calmodulin-dependent serine protein kinase (CASK) staining had a significantly better survival compared to patients with high CASK staining. PMID: 24927672
    10. The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane. PMID: 23542924
    11. CASK regulates CaMKII autophosphorylation in a pathway required for memory formation. PMID: 23543616
    12. a model whereby CASK recruits FRMD7 to the plasma membrane to promote neurite outgrowth during development of the oculomotor neural network and that defects in this interaction result in nystagmus. PMID: 23406872
    13. our findings suggest a molecular mechanism by which CASK binding regulates SAP97 conformation and its subsequent sorting and synaptic targeting of AMPARs and NMDARs during trafficking to synapses. PMID: 23864692
    14. CASK represents an intracellular gateway to regulate purinergic nociceptive signaling. PMID: 23600800
    15. An early diagnosis and be useful for medical care of females with ID and MICPCH associated with CASK mutations. PMID: 23165780
    16. CASK combines the scaffolding activity of MAGUKs with an unusual kinase activity that phosphorylates substrates recuited by the scaffolding activity. PMID: 18423203
    17. case reports - mutations resulting in Ohtahara syndrome and cerebellar hypoplasia PMID: 22709267
    18. During wounding, CASK is mobilized to the plasma membrane where it colocalizes with Cx43 and CADM1 1 hour after skin explant wounding. PMID: 22389404
    19. CASK related PCH is the second most frequent cause of PCH. The identification of a de novo mutation in these patients enables accurate and reassuring genetic counselling PMID: 22452838
    20. Intragenic duplications and mutations of CASK is associated with mental retardation and microcephaly with pontine and cerebellar hypoplasia PMID: 21735175
    21. Heterozygous mutations in the CASK gene are described in 20 female patients that are associated with distinct brain malformations and phenotypes of remarkably varying degrees. PMID: 21954287
    22. The liprin-alpha2/CASK complex structure is solved here. PMID: 21855798
    23. Study shows that a short linear EEIWVLRK peptide motif from Caskin1 is necessary and sufficient for binding CASK. PMID: 21763699
    24. CASK plays a role in axonogenesis, which may be related to brain anatomical characteristics in humans PMID: 20623620
    25. These findings reinforce the CASK gene as a relatively frequent cause of X-linked mental retardation in females and males. PMID: 20029458
    26. syndecan's interactions with both CASK and neurofibromin are dependent on syndecan homodimerization. PMID: 20006588
    27. Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation. PMID: 19781660
    28. Upregulation of CASK protein is associated with tumorigenesis of esophagus PMID: 11880184
    29. coordinated folding and association of the LIN-2, -7 domain PMID: 12110687
    30. plasma membrane Ca2+ pump 4b/CI binds to Ca2+/calmodulin-dependent membrane-associated kinase CASK PMID: 12511555
    31. Thus, we speculate that the regulation of cell growth mediated by CASK may be involved in Id1. PMID: 15694377
    32. Genetic deletion of CASK results in haploinsufficiency, which might cause X-linked dominant mental retardation. PMID: 18629876
    33. CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. PMID: 18664494
    34. hCASK regulation of cell growth might involve p21 expression, and that the bHLH (basic helix-loop-helix) transcription factor E2A probably participates in hCASK regulation of p21 expression PMID: 19125693
    35. Here we describe a previously unreported X-linked brain malformation syndrome caused by mutations of CASK PMID: 19165920
    36. study reports that a p.R28L (c.83G-->T) missense mutation in CASK causes FG syndrome phenotype in an Italian family PMID: 19200522
    37. The molecular functions of CASK may explain, at least partially in this review, the malformations of the brain and the mental retardation in human patients carrying mutations in the CASK gene. PMID: 19847910

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH); FG syndrome 4 (FGS4)
  • 亞細胞定位:
    Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily; MAGUK family
  • 組織特異性:
    Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1497

    OMIM: 300172

    KEGG: hsa:8573

    STRING: 9606.ENSP00000367408

    UniGene: Hs.495984



主站蜘蛛池模板: 欧美老熟妇videos极品另类| 97熟女毛毛多熟妇人妻aⅴ| 最新精品国偷自产在线美女足| 免费无遮挡无码永久在线观看视频 | 亚洲中文久久精品无码照片| 乱子伦av无码中文字| 黄瓜视频在线观看网址| 国产午夜亚洲精品不卡在线观看| 欧美s码亚洲码精品m码| 亚洲熟女综合一区二区三区| 一本天堂v无码亚洲道久久| 国产熟妇乱子伦视频在线观看 | 九九九精品成人免费视频小说| 妺妺窝人体色www婷婷| 亚洲国产一区二区波多野结衣| 午夜无码片在线观看影院y| 亲近乱子伦免费视频| 亚洲精品一区二区久| 亚洲第一成年免费网站| 久久久久久亚洲精品a片成人| 爆乳2把你榨干哦ova在线观看| 成人毛片一区二区| 亚洲a成人无m网站在线| 337p日本欧洲亚洲大胆精筑 | 人妻久久久精品99系列2021| 日韩精品无码不卡无码| 亚洲综合国产成人丁香五月激情 | 日韩精品成人av在线观看| 精品人妻av区乱码| 女人喷水高潮时的视频网站| 亚洲精品无码不卡av| 精品无码国产av一区二区三区| 亚洲精品一区二区三区新线路 | 免费无码av片流白浆在线观看| 色老板精品视频在线观看| 亚洲国产精品成人精品无码区在线| 国产精品亚洲综合色区| 女人高潮抽搐喷液30分钟视频| 精品乱码久久久久久中文字幕| 七妺福利精品导航大全| 国产三级精品三级在线观看|