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CARMIL1 Antibody

  • 中文名稱：
    CARMIL1兔多克隆抗體
  • 貨號：
    CSB-PA713356LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA713356LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CARMIL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CARMIL1
  • 別名：
    Acan 125 antibody; Capping protein; Arp2/3; and myosin I linker antibody; CARMIL homolog antibody; leucine rich repeat containing 16 antibody; Leucine-rich repeat-containing protein 16A antibody; LR16A_HUMAN antibody; Lrrc16 protein antibody; LRRC16A antibody; p116 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human F-actin-uncapping protein LRRC16A protein (1184-1295AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CARMIL1 Antibody (CSB-PA713356LA01HU)，的標記方式是Non-conjugated。對于CARMIL1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA713356LB01HU CARMIL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA713356LC01HU CARMIL1 Antibody, FITC conjugated
    Biotin CSB-PA713356LD01HU CARMIL1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration.
  • 基因功能參考文獻：
    1. A novel genetic variant in leucine-rich repeat-containing 16A (LRRC16A) has been associated with reduced ARDS risk. PMID: 27768389
    2. LRRC16A plays a role in adult respiratory distress syndrome pathophysiology by interacting with, and being mediated through, platelets. PMID: 25254322
    3. shown for the first time that CARMIL/LRRC16A was associated with gout, which could be due to urate transportsome failure PMID: 24318514
    4. The results also suggest that the ability of CARMIL1 to inhibit CP in cells may be regulated. PMID: 23904264
    5. Data suggest that CARMIL promotes uncapping by binding to a freely accessible site on Capping protein (CP) bound to a filament barbed end and inducing a change in the conformation of the actin-binding surface of CP. PMID: 22411988
    6. The two CARMIL isoforms are both important for cell migration, but they have distinct functions.[CARMIL1, CARMIL2] PMID: 19846667

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium.
  • 蛋白家族：
    CARMIL family
  • 組織特異性：
    Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
  • 數據庫鏈接：

    HGNC: 21581

    OMIM: 609593

    KEGG: hsa:55604

    STRING: 9606.ENSP00000331983

    UniGene: Hs.649550



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