在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CAPRIN1 Antibody

  • 中文名稱:
    CAPRIN1兔多克隆抗體
  • 貨號:
    CSB-PA004505GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    activation/proliferation-associated protein 1 antibody; CAPR1_HUMAN antibody; Caprin-1 antibody; CAPRIN1 antibody; Cell cycle-associated protein 1 antibody; Cytoplasmic activation- and proliferation-associated protein 1 antibody; cytoplasmic activation/proliferation-associated protein-1 antibody; GPI-anchored membrane protein 1 antibody; GPI-anchored protein p137 antibody; GPI-p137 antibody; GPIAP1 antibody; GPIP137 antibody; M11S1 antibody; Membrane component chromosome 11 surface marker 1 antibody; p137GPI antibody; RNA granule protein 105 antibody; RNG105 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CAPRIN1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
  • 基因功能參考文獻:
    1. that high Caprin1 expression was significantly associated with worse overall survival for patients with hepatocellular carcinoma PMID: 29037839
    2. Based on insights from the structures and existing biochemical data, the existence of an evolutionarily conserved ribonucleoprotein (RNP) complex consisting of Caprin-1, FMRP and G3BP1 is proposed. PMID: 27303792
    3. Data suggest that DEAD-box helicase 3 (DDX3X) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (via gene silencing with the CRISPR-Cas system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line. PMID: 28733330
    4. G3BP mediates the condensation of stress granules by shifting between two different states that are controlled by the phosphorylation of S149 and by binding to Caprin1 or USP10. PMID: 27022092
    5. The G3BP1-Caprin1-PKR complex represents a new mode of PKR activation and is important for antiviral activity of G3BP1 and PKR during infection with mengovirus. PMID: 25784705
    6. Data show that tylophorine compounds exert anti-cancer activity predominantly by targeting and sequestering the caprin-1 protein and c-Myc mRNA associated ribonucleoprotein complex. PMID: 25669982
    7. G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. PMID: 24992036
    8. Cyr61/Caprin-1 co-expression was associated with worse survival. PMID: 23528710
    9. These results suggest that the Japanese encephalitis virus core protein circumvents translational shutoff by inhibiting stress granule formation through an interaction with Caprin-1 and facilitates viral propagation in vitro and in vivo. PMID: 23097442
    10. Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes PMID: 22737234
    11. Homologous region-1 (HR-1) is a novel protein domain that has been identified near the N-terminus of human caprin-1; highly conserved in vertebrates and insects, it is also present in the human caprin-2 paralog. PMID: 14764709
    12. involvement of cellular protein p137 in transcription of intermediate stage genes may regulate the transition between early and late phases of vaccinia virus replication PMID: 15471883
    13. Suppression of expression of human Caprin-1 results in slowing of the proliferation rate, due to prolongation of the G1 phase of the cell cycle, formally demonstrating that Caprin-1 is essential for normal cellular proliferation. PMID: 16177067
    14. Caprin-1/G3BP-1 complex is likely to regulate the transport and translation of mRNAs of proteins involved with synaptic plasticity in neurons PMID: 17210633
    15. MiR-16 negatively regulate HMGA1 and caprin-1 which are involved in cell proliferation. PMID: 19250063

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Cell projection, dendrite. Cell projection, lamellipodium.
  • 蛋白家族:
    Caprin family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 6743

    OMIM: 601178

    KEGG: hsa:4076

    STRING: 9606.ENSP00000340329

    UniGene: Hs.471818



主站蜘蛛池模板: 国产白丝精品爽爽久久蜜臀| 亚洲多毛妓女毛茸茸的| 久久99精品久久久久久| 深夜国产一区二区三区在线看 | 国精产品一二三区精华液| 国产成人亚洲综合无码精品| 大地资源中文第3页| 人妻少妇精品专区性色av| 日韩欧美亚洲中文乱码| 国产高清不卡一区二区| 中出人妻中文字幕无码| 国产99视频精品免费视看9| 精品无人乱码高清| 久久久国产乱子伦精品| 日本高清视频在线www色| av人摸人人人澡人人超碰小说| 亚洲欧美日韩中文加勒比| 亚洲国产超清无码专区| 欲色欲色天天天www| 在线精品自偷自拍无码| 国产精品自在欧美一区| 18处破外女出血在线| 久久露脸国产精品| 性欧美老妇另类xxxx| 久久人妻内射无码一区三区| 精品无码欧美黑人又粗又| 国产亚洲精品一区二三区| 亚洲精品久久久久午夜福禁果tⅴ| 国产精品爱久久久久久久| 九九视频国产免| 亚洲国产制服丝袜先锋| 综合亚洲伊人午夜网| 国产精品www夜色视频| 亚洲精品久久午夜无码一区二区| 97久久国产成人免费网站| 久久久精品人妻一区二区三区蜜桃| 久久久婷婷五月亚洲97号色| 亚洲国产精品无码中文在线| 男女啪啦啦超猛烈动态图| 天天做天天爱夜夜夜爽毛片| 国产乱对白刺激视频|