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CAMK1D Antibody

  • 中文名稱:
    CAMK1D兔多克隆抗體
  • 貨號:
    CSB-PA004463GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CAMK1D
  • 別名:
    A630059D12Rik antibody; Calcium/calmodulin dependent protein kinase ID antibody; Calcium/calmodulin dependent protein kinase type 1D antibody; Calcium/calmodulin-dependent protein kinase I-delta antibody; Calcium/calmodulin-dependent protein kinase type 1D antibody; CaM K1 antibody; CaM KI delta antibody; CaM kinase I delta antibody; CaM kinase ID antibody; CaM-KI delta antibody; CAMK 1D antibody; CAMK1D antibody; CaMKI delta antibody; CamKI like protein kinase antibody; CamKI-like protein kinase antibody; CaMKID antibody; CKLiK antibody; E030025C11Rik antibody; KCC1D_HUMAN antibody; OTTHUMP00000019119 antibody; OTTHUMP00000019120 antibody; OTTHUMP00000045030 antibody; RP11 462F15.1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CAMK1D
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
  • 基因功能參考文獻:
    1. There were no statistically significant differences in the distribution of CDC123/CAMK1D rs12779790 genotypes and alleles between women with gestational diabetes mellitus and healthy pregnant women. PMID: 28079868
    2. identified the CAMK1D gene as a novel locus associated with blood pressure response to losartan PMID: 25410890
    3. Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1). PMID: 22923468
    4. A significant association of rs10906115 in CDC123/CAMK1D and rs1359790 near SPRY2 was identified with type 2 diabetes in a Japanese population. PMID: 21909839
    5. role of CKLiK in specific granulocyte effector functions such as phagocytosis, respiratory burst, migration, and adhesion PMID: 15840691
    6. CAMK1D as a novel amplified oncogene linked to epithelial-mesenchymal transition in breast cancer, with elevated expression in invasive carcinomas compared to carcinoma in situ PMID: 19383354

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  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 組織特異性:
    Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes.
  • 數據庫鏈接:

    HGNC: 19341

    OMIM: 607957

    KEGG: hsa:57118

    STRING: 9606.ENSP00000368124

    UniGene: Hs.600547



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