在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CAMK1 Antibody

CAMK1 Antibody

  • 中文名稱：
    CAMK1兔多克隆抗體
  • 貨號：
    CSB-PA128065
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA128065(CAMK1 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CAMK1
  • 別名：
    Calcium / calmodulin dependent protein kinase 1 antibody; Calcium / calmodulin dependent protein kinase I antibody; Calcium / calmodulin dependent protein kinase type 1 antibody; Calcium/calmodulin dependent protein kinase 1 antibody; Calcium/calmodulin dependent protein kinase I antibody; Calcium/calmodulin dependent protein kinase type 1 antibody; Calcium/calmodulin-dependent protein kinase type 1 antibody; CaM K1 antibody; CaM KI antibody; CaM kinase 1 alpha antibody; CAM kinase 1 antibody; CaM kinase I alpha antibody; CaM kinase I antibody; CaM-KI antibody; CaMK 1 antibody; CAMK I antibody; CaMK1 alpha antibody; CAMK1 antibody; CAMK1 PEN antibody; CaMKI alpha antibody; CaMKI-alpha antibody; KCC1A_HUMAN antibody; MGC120317 antibody; MGC120318 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CAMK1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:10-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
  • 基因功能參考文獻：
    1. The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients PMID: 27907007
    2. Barettin has inhibitory activity against two protein kinases related to inflammation, namely the receptor-interacting serine/threonine kinase 2 (RIPK2) and calcium/calmodulin-dependent protein kinase 1alpha (CAMK1alpha). PMID: 26466644
    3. CAMK1 functional regulation subnetwork in hepatocellular carcinoma PMID: 24825433
    4. this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A and CaMKI and PME-1 networks may function in fine-tuning cell proliferation and stress response. PMID: 24841198
    5. It is one of Ca(2+)-sensing proteins and substantial age- and Alzheimer disease(AD)-related alterations in Ca(2+)-sensing proteins most likely contribute to selective vulnerability of basal forebrain cholinergic neurons to degeneration in AD. PMID: 24461366
    6. Fbxl12-induced CaMKI degradation attenuates p27 phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 phosphorylation appears to be upstream to other p27 phosphorylation events PMID: 23707388
    7. structures of three CaMKIalpha truncates in apo form and in complexes with ATP PMID: 23028635
    8. CaMKI was significantly upregulated in adrenal adenomas. PMID: 21249615
    9. variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, have roles in memory and general cognitive abilities PMID: 19844571
    10. CaMKI is involved in angiotensin II and K(+) stimulation of CYP11B2 transcription and the capacity of the adrenal to produce aldosterone PMID: 12193581
    11. we cloned a novel calmodulin-kinase (CaM-KIdelta) from HeLa cells and characterized its activation mechanism. CaM-KIdelta exhibits Ca(2+)/CaM-dependent activity that is enhanced in vitro by phosphorylation of its Thr180 by CaM-K kinase (CaM-KK)alpha PMID: 12935886
    12. calcium/calmodulin-dependent protein kinase I regulates of cyclin D1/Cdk4 complexes PMID: 14754892
    13. Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation PMID: 15251453
    14. Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. PMID: 18089838

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 組織特異性：
    Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex.
  • 數據庫鏈接：

    HGNC: 1459

    OMIM: 604998

    KEGG: hsa:8536

    STRING: 9606.ENSP00000256460

    UniGene: Hs.434875



主站蜘蛛池模板： 日日摸日日碰夜夜爽免费| 国产v亚洲v天堂无码久久久| 波多野结衣av在线无码中文18| 国产老熟女网站| 成人免费看黄网站yyy456| 国产情侣真实54分钟在线| 婷婷色婷婷开心五月四房播播久久| 久久婷婷是五月综合色| 久久久久久午夜成人影院| 九月婷婷人人澡人人添人人爽| 国产成人精品久久久久精品日日 | 99这里只有精品| 四虎国产精品永久在线国在线| 国产99青草视频在线播放视| 国产成人啪精品视频网站午夜| 日本乱偷人妻中文字幕在线 | 在线涩涩免费观看国产精品| 精品国产亚洲午夜精品av | 99久久精品国产一区二区三区 | 色六月婷婷亚洲婷婷六月| 人妻丰满熟av无码区hd| 搡老女人老妇女老熟妇| 少妇精品无码一区二区三区| 国产欧美日韩视频怡春院| 国产美女遭强高潮网站下载| 在线观看国产一区二区三区| 五十路亲子中出在线观看| 天天摸夜夜添狠狠添高潮出水 | 娜娜麻豆国产电影| 国精一二二产品无人区免费应用| 精品少妇人妻av一区二区三区| 亚洲高清无在码在线电影| 2021精品亚洲中文字幕| 老师粉嫩小泬喷水视频90| 日本免费一区二区三区四区五六区 | 波多野结衣乳巨码无在线| 天堂а√在线最新版中文在线| 色8久久人人97超碰香蕉987| 亚洲精品午夜无码电影网| 国产精品久久久久久人妻精品动漫| 国产精品久久久一区二区|