在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CALML3 Antibody

  • 中文名稱:
    CALML3兔多克隆抗體
  • 貨號(hào):
    CSB-PA004453DSR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA004453DSR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CALML3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CALL3_HUMAN antibody; CALML3 antibody; Calmodulin like 3 antibody; Calmodulin related protein NB 1 antibody; Calmodulin-like protein 3 antibody; Calmodulin-related protein NB-1 antibody; CaM like protein antibody; CaM-like protein antibody; CLP antibody; OTTHUMP00000019004 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Calmodulin-like protein 3 protein (1-149AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.
  • 基因功能參考文獻(xiàn):
    1. Metformin suppresses gastric cancer through stimulating Calml3 secretion from TAFs. PMID: 30320344
    2. UVB irradiation induced increase in apoptosis, Reactive Oxygen Species production and Ca2+ concentration of human lens epithelial cells , in part, by downregulating the expression of CALML3 and involved oxidative stress, Ca2+, JNK1/2 and ERK1/2 signaling pathways, suggesting that investigating CALML3 may useful for developing cataract treatment. PMID: 29436594
    3. We identified calmodulin-like protein 3 (CALML3) as a key sensor of this SNP and a coregulator of ERalpha, which contributes to differential gene transcription regulation in an estrogen and SERM-dependent fashion. Furthermore, using CRISPR/Cas9-engineered ZR75-1 breast cancer cells with different ZNF423 SNP genotypes, striking differences in cellular responses to SERMs and PARP inhibitors, alone or in combination PMID: 28821270
    4. Loss of CALML3 predicts shorter overall and relapse-free survival in postoperative hepatocellular carcinoma (HCC) patients, thus providing a prognostic biomarker and therapy target in HCC. PMID: 29445139
    5. Increased CALML3 expression in suprabasal layers is characteristic for differentiating keratinocytes in normal epidermis, and nuclear expression of CALML3 inversely correlates with expression of the proliferation marker Ki-67. PMID: 23638045
    6. CLP may be required during terminal differentiation to increase myosin-10 function as cells migrate toward the upper layers and establish new adhesive contacts. PMID: 17130134
    7. increased CLP expression and CLP-mediated Myo10 function are important for skin differentiation and wound reepithelialization PMID: 18818677
    8. expression was readily detected in areas of normal oral mucosa, while a notable downregulation of expression occurred in areas of malignant transformation PMID: 19166543

    顯示更多

    收起更多

  • 蛋白家族:
    Calmodulin family
  • 組織特異性:
    Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 1452

    OMIM: 114184

    KEGG: hsa:810

    STRING: 9606.ENSP00000315299

    UniGene: Hs.239600



主站蜘蛛池模板: 日本边添边摸边做边爱边| 免费人成网站在线观看不卡| 在教室伦流澡到高潮hgl动漫| 亚洲日韩乱码中文无码蜜桃臀网站| 国产日韩成人内射视频| 亚洲精品白浆高清久久久久久| av无码久久久久不卡蜜桃| 中文字幕免费无码专区| 国产热re99久久6国产精品首页 | 精品国产乱码久久久久久免费| 国产成+人+综合+亚洲欧美丁香花| 男人和女人高潮做爰视频| 日本二区三区欧美亚洲国| 人妻无码久久精品| 久久无码专区国产精品s| 医院人妻闷声隔着帘子被中出 | 国产-第1页-浮力影院| 国产免费人成在线视频网站| 香港三级日本三级韩级人妇| 久久不见久久见免费影院| 亚洲人成影院在线无码按摩店| 免费两性的视频网站| 中文字幕久久精品波多野结百度| 性高湖久久久久久久久aaaaa| 伊人久久精品在热线热| 午夜香蕉成视频人网站| 亚洲国产精品尤物yw在线观看| 中文字幕乱码人妻二区三区| 国产公妇仑乱在线观看| 99久久精品6在线播放| 亚洲午夜未满十八勿入网站| 九九精品成人免费国产片| 日韩av无码中文无码电影| 狠狠躁夜夜躁人人躁婷婷视频| 国产精品186在线观看在线播放| 中文字幕丰满伦子无码| 亚洲欲色欲香天天综合网| 国产午夜精品一区理论片飘花| 狠狠躁夜夜躁人人爽天天| 人妻丰满熟妇av无码区动漫| 国产黄a三级三级三级|