在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CALD1 Antibody

  • 中文名稱:
    CALD1兔多克隆抗體
  • 貨號:
    CSB-PA060174
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CAD antibody; CALD 1 antibody; CALD1 antibody; CALD1_HUMAN antibody; Caldesmon 1 antibody; Caldesmon 1 Isoform 1 antibody; Caldesmon 1 Isoform 2 antibody; Caldesmon 1 Isoform 3 antibody; Caldesmon 1 Isoform 4 antibody; Caldesmon 1 Isoform 5 antibody; Caldesmon antibody; Caldesmon1 antibody; CDM antibody; H CAD antibody; HCAD antibody; L CAD antibody; LCAD antibody; MGC21352 antibody; NAG22 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human Caldesmon around the non-phosphorylation site of S759.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration.
  • 基因功能參考文獻:
    1. rs 3807337 polymorphism of CALD1 gene is associated with diabetic nephropathy occurrence in type 1 diabetes. PMID: 28255976
    2. ANXA1 and CALD1 proteins are independent markers for tamoxifen therapy outcome and are associated to fast tumor progression. PMID: 26657294
    3. Data indicate that low-molecular-weight caldesmon isoforms (L-CAD) promotes migration and invasiveness of urothelial bladder carcinoma (BC) cells. PMID: 26430961
    4. Caldesmon and smoothelin staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas. PMID: 24551305
    5. caldesmon is not useful in distinguishing between peritoneal epithelioid mesotheliomas and papillary serous carcinomas involving the peritoneum PMID: 23196794
    6. The data suggest that PKGIbeta enhances breast cancer cell motility and invasive capacity, at least in part, by phosphorylating CaD. PMID: 23418348
    7. Caldesmon is a possible predictor of endometrial dysregulation in patients with endometriosis. PMID: 23575144
    8. Caldesmon expression inhibits cancer cell migration and invasiveness. PMID: 23265641
    9. Disruption of the normal inhibitory function of human caldesmon 1 enhances intestinal peristalsis in both wild-type zebrafish larvae and mutant larvae that lack enteric nerves PMID: 22316291
    10. Data found phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium. PMID: 21738699
    11. Our results show a differential behavior of h- and l-caldesmon isoforms in epithelium and stroma of colon adenocarcinoma and lymph node metastases. PMID: 21626272
    12. Novel biological cascade that involved the phosphorylation activation of CaD by PFTK1 kinase in promoting formation of actin stress fibers. PMID: 21184254
    13. An involvement of caldesmon in the susceptibility to diabetic nephropathy in type 1 diabetes, independently from environmental glucose levels. PMID: 20801058
    14. h-caldesmon is useful in distinguishing atypical polypoid adenomyoma from myoinvasive endometrioid carcinoma PMID: 21131830
    15. Stretch activates myometrium via ERK, caldesmon and focal adhesion signaling PMID: 19834610
    16. Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID: 19764806
    17. The effect of a C-terminal fragment of CaD (H32K) on the kinetics of the in vitro actin polymerization by monitoring the fluorescence of pyrene-labeled actin, was studied. PMID: 19889635
    18. Specific but variable expression of h-caldesmon in leiomyosarcomas PMID: 11759055
    19. Motifs of the caldesmon family. PMID: 11996092
    20. results suggest a role for the caldesmon gene in susceptibility to diabetic nephropathy in type 1 diabetes PMID: 15047636
    21. Alternative splicing contributes to dysfunctionality of glioma neovascularization. PMID: 15161654
    22. plays a crucial role in mediating the effects of Ca(2+)-calmodulin on the dynamics of the actin cytoskeleton PMID: 15226374
    23. unphosphorylated, but not ERK-phosphorylated, caldesmon could stabilize actin filaments and resist F-actin severing or depolymerization in both smooth muscle and nonmuscle cells PMID: 15456752
    24. These results suggest that CaD is critically involved in the regulation of the actin cytoskeleton and migration in EC, and that p38 MAPK-mediated CaD phosphorylation may be involved in endothelial cytoskeletal remodeling. PMID: 15521070
    25. Serum l-CaD level as determined by ELISA is a good discriminator between glioma patients versus patients with other intracranial tumor. PMID: 15958622
    26. K-cyclin expression modulates the activity of caldesmon and through this the microfilament functions in cells PMID: 16115893
    27. Phosphorylation of caldesmon by PAK is a dynamic process required to regulate actin dynamics and membrane protrusions in wound-induced cell migration. PMID: 16800003
    28. low molecular weight isoform CaD undergoes a DNA replication-associated switch in localization from the cytoplasm to the nuclei of endothelial cells/endothelial progenitor cells in human tumor vasculature PMID: 17582218
    29. Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. PMID: 17631293
    30. A subset of the tumor-specific splicing alterations (ACTN1, CALD1, and VCL) was found in all three organs and may represent general cancer-related splicing events. PMID: 18353764
    31. GR directly bound to the two glucocorticoid-response element-like sequences in the human CALD1 promoter and transactivated the CALD1 gene, thereby up-regulating the CaD protein. PMID: 18772142
    32. Vaginal caldesmon expression is significantly decreased in women with anterior vaginal wall prolapse compared to normal subjects PMID: 19582387

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Cytoplasm, cytoskeleton, stress fiber.
  • 蛋白家族:
    Caldesmon family
  • 組織特異性:
    High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
  • 數據庫鏈接:

    HGNC: 1441

    OMIM: 114213

    KEGG: hsa:800

    STRING: 9606.ENSP00000354826

    UniGene: Hs.490203



主站蜘蛛池模板: 国产午夜精品无码一区二区 | 女人扒下裤让男人桶到爽| 成人特级毛片www免费版| 67194熟妇在线观看线路1| 99久久精品日本一区二区免费| 永久免费无码成人网站| 久久久女人与动物群交毛片| 国产全是老熟女太爽了| 精品国产品香蕉在线| 亚洲欧美色一区二区三区| 人人妻人人爽人人澡欧美一区| 日韩做a爰片久久毛片a片| 国产高清自产拍av在线| 人人妻人人狠人人爽| 亚洲欧洲日产最新| 亚洲高清国产拍精品26u| 国产熟人av一二三区| 日本少妇被黑人xxxxx| 粉嫩被粗大进进出出视频| 国语对白嫖老妇胖老太| 国产熟妇乱xxxxx大屁股网| 99精品一区二区三区无码吞精| 亚洲精品无码专区在线观看| 国产精品无码久久综合网| 欧美最猛黑人xxxxx猛交| 东京热一区二区三区无码视频| 亚洲 综合 校园 欧美 制服| 无码免费中文字幕视频| 99久久99久久精品免费看蜜桃| 久久精品国产亚洲一区二区| 少妇人妻中文字幕hd| 377p欧洲日本亚洲大胆| 十八禁视频网站在线观看| 亚洲欧洲日产韩国在线看片| 99大香伊乱码一区二区| 黄a大片av永久免费| 国产成人麻豆精品午夜福利在线| 欧美 亚洲 国产 制服 中文| 久久精品伊人一区二区三区| 野狼av午夜福利在线| 日韩去日本高清在线|