在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CADM1 Antibody

  • 中文名稱:
    CADM1兔多克隆抗體
  • 貨號:
    CSB-PA112392
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, using CADM1 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CADM1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from C-terminal of Human CADM1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. May contribute to the less invasive phenotypes of lepidic growth tumor cells.
  • 基因功能參考文獻(xiàn):
    1. miRNA-873 promoted Hepatocellular Carcinoma progression by targeting TSLC1. PMID: 29734164
    2. High CADM1 expression is associated with KSHV infection. PMID: 29698475
    3. the immunohistochemical expression of CADM1 has the potential to contribute as an auxiliary tool to the differential diagnosis between nevi and melanomas. PMID: 28843749
    4. These findings suggest that CADM1 expression is a novel prognostic factor for peripheral T cell lymphoma, not otherwise specified PMID: 28940014
    5. miR-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1, and an inverse correlation between miR-21 and CADM1 expression in vivo. MiR-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer PMID: 27055844
    6. We conclude that CADM1 was not associated with cell-cell interaction between lymphoma cells and macrophages, although CADM1 may be a useful marker of ATLL for diagnostic procedures. PMID: 28420814
    7. miR-21 overexpression promotes cardiac fibrosis via STAT3 signaling pathway by decrease CADM1 expression, indicating miR-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation. PMID: 28335740
    8. Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (cg16962115, FDR = 1.24E-04), CADM1 (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02) PMID: 28637314
    9. CADM1 mRNA expression was highly upregulated in normal tissues compared to esophageal squamous cell carcinoma tissues, indicating that the loss of CADM1 expression influenced the pathogenesis, invasion, and metastasis of ESCC. PMID: 28510248
    10. Eight and five of the nine samples were negative for cell adhesion molecule 1 and Osterix respectively. The other markers showed no statistical significance(CD151,ALP). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues PMID: 28651491
    11. Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re... PMID: 27072493
    12. High expression of CADM1 on most HTLV-1-infected cells in the face of enhanced cytotoxic T lymphocyte counterselection implies that CADM1 confers a strong benefit on the virus. PMID: 27105228
    13. Decreased expression of TSLC1 is associated with the differentiation in ovarian epithelial cancer. TSLC1 might be used as a molecular marker of severity in early stage ovarian cancer, and to help differentiating benign and malignant ovarian tumors. PMID: 27146728
    14. Suppression of tumorigenesis by CADM1 may be mediated by the Rb-E2F1 pathway. PMID: 27298105
    15. CADM1 prevents squamous cell carcinoma progression by reducing STAT3 activity PMID: 27035095
    16. Decreased expression of TSLC1 is correlated with the malignancy of non-muscle invasive bladder cancer tissues and low TSLC1 expression may serve as a predictor for bladder cancer recurrence and progression. PMID: 26894268
    17. CADM1 deletion is associated with neuroblastoma and ganglioneuroma. PMID: 26463893
    18. Hypermethylation of CADM1 gene may be highly associated with the development of cervical cancer. PMID: 26552048
    19. Our study showed that miR-126, by down-regulation CADM1, enhances migration and invasion in gastric cancer cells. PMID: 26464628
    20. This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas PMID: 26772392
    21. CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia PMID: 26219541
    22. SynCAM1 delineates the postsynaptic perimeter of the synaptic cleft as determined by immunoelectron microscopy. PMID: 26687224
    23. increased CADM1 shedding appeared to contribute to the development of emphysema by generating alphaCTF and the ICD in lung epithelial cells. PMID: 26259600
    24. CADM1 shedding is increased in idiopathic interstitial pneumonia and contributes to alveolar epithelial cell apoptosis. PMID: 26231557
    25. Results show that CADM1 is downregulated in HPV-positive cervical cancers and that epigenetic alteration of CADM1 was more frequent in this type of cancer. The restoration of CADM1 expression may be a potential strategy for cervical cancer therapy. PMID: 25845528
    26. The use of CADM1, MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus. PMID: 26473640
    27. CADM1 induction was repressed in primary samples from AML patients at relapse. PMID: 25491945
    28. Our study reveals a novel mechanism of chronic NF-kappaB activation by CADM1 in HTLV-1 infected cells PMID: 25774694
    29. Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. PMID: 25268382
    30. In the absence of SynCAMs, selective axon-axon interactions are perturbed resulting in aberrant pathfinding of sensory axons. PMID: 25335893
    31. Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata. PMID: 24964098
    32. In a population-based association study, we confirm a role for CADM1 variants in increasing the risk of VT by interaction with protein C pathway abnormalities. PMID: 25306186
    33. The significant association of IGSF4 with HPV-positive head and neck squamous cell carcinoma suggests that HPV-positive tumors are to a greater extent driven by promoter hypermethylation in this tumor suppressor gene. PMID: 25569158
    34. HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation. PMID: 25065733
    35. CADM1/TSLC1 is an antiinvasive gene, the overexpression of which inhibits the invasion of A375 cells. PMID: 25215547
    36. Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as triage tool on cervical scrapes of HPV positive women. PMID: 25667975
    37. TSLC1-AS1 was a tumor suppressor of glioma and a mediator of TSLC1 expression. PMID: 25031725
    38. The study showed that CADM1 is a direct target of miR-1246 leading to its down regulation in hepatocellular carcinoma cells. PMID: 25159494
    39. DNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer PMID: 25281766
    40. Loss of CADM1 expression is an independent prognostic factor especially associated with the development of brain metastases in breast cancer patients. PMID: 24833255
    41. We showed that the CADM1 versus CD7 plot is capable of discriminating clonally expanding HTLV-I-infected cells in indolent and acute-type T-cell leukemia-lymphomas and in asymptomatic carriers PMID: 24727323
    42. MPP3 and Dlg, membrane-associated guanylate kinase homologs (MAGuK) proteins, connect CADM1 with p85 of PI3K by forming a multi-protein complex at the periphery of cells. PMID: 24503895
    43. Data suggest that cell adhesion molecule 1 (CADM1) is a key adhesion receptor, which regulates mast cells (MCs) net adhesion. PMID: 24465823
    44. TGF-beta upregulates miR-182 expression to promote gallbladder cancer metastasis by targeting CADM1. PMID: 24445397
    45. CADM1 ectodomain shedding appeared to cause alveolar cell apoptosis in emphysematous lungs by producing alphaCTF that accumulated in mitochondria. PMID: 24092566
    46. The paper shows that CADM1 regulates mast cell net adhesion, both directly through CADM1-dependent adhesion, and indirectly through the regulation of other adhesion receptors. The latter is likely to occur via docking of KIT and polymerization of cortical F-actin. CADM1 is involved in docking of KIT to the cell surface and phosphotyrisine signaling, and polymerization of cortical F-actin. PMID: 24465823
    47. SynCAM, a novel putative tumor suppressor, suppresses growth and invasiveness of glioblastoma. PMID: 23907434
    48. Infection of NCI-H460, A549, and H1299 lung cancer cells with Ad.sp-E1A(Delta24)-TSLC1 induced apoptosis. PMID: 23503473
    49. Data suggest that tumor suppressor in lung cancer 1 (TSLC1) as tumor suppressor may play prominent roles in development and progression of cutaneous squamous cell carcinoma (CSCC) via regulation of different biological processes. PMID: 23812766
    50. The cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM. PMID: 23871486

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
  • 蛋白家族:
    Nectin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 5951

    OMIM: 605686

    KEGG: hsa:23705

    STRING: 9606.ENSP00000395359

    UniGene: Hs.370510



主站蜘蛛池模板: 精品无码国产av一区二区三区| 亚洲精品四区麻豆文化传媒| 国产少妇高潮在线观看| 香港三级日本三级韩级人妇| 国内精品九九久久精品| 免费无码又爽又刺激高潮| 男女同房做爰爽免费| 欧美性性性性o00xx| 无遮挡十八禁污污污网站| 欧洲美女粗暴牲交免费观看 | 久久无码av三级| 中文字幕卡二和卡三的视频| 六月丁香亚洲综合在线视频| 国产在线视频一区二区三区98| 无码专区一va亚洲v专区在线 | 女人爽到高潮潮喷18禁网站| av中文无码乱人伦在线观看| 国产一区二区不卡在线看| 欧美日韩精品一区二区在线观看| 中国妇女做爰视频| 麻豆精品国产精华精华液好用吗 | 欧美香蕉爽爽人人爽| 精品国产电影久久九九| 国产精品对白刺激久久久| 99久久精品日本一区二区免费| 日本www一道久久久免费| 国产成人精品一区二区秒播| 免费观看成人毛片a片| 日日拍夜夜嗷嗷叫国产| 无码国产一区二区三区四区| 色天使久久综合给合久久97色| 国内精品九九久久精品| 欧美孕妇乳喷奶水在线观看| 女人高潮抽搐潮喷小视频| 米奇7777狠狠狠狠视频影院| аⅴ资源中文在线天堂| 欧美变态暴力牲交videos| 国产精品嫩草99av在线| 青青草视频在线观看| 性生交大片免费看l| 女人的天堂a国产在线观看|