在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CA4 Antibody, FITC conjugated

CA4 Antibody, FITC conjugated

  • 中文名稱：
    CA4兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA004372LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CA4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CA4
  • 別名：
    CA IV antibody; CA4 antibody; CAH4_HUMAN antibody; CAIV antibody; Car4 antibody; Carbonate dehydratase IV antibody; Carbonic anhydrase 4 antibody; Carbonic dehydratase antibody; Carbonic dehydratase IV antibody; EC 4.2.1.1 antibody; Retinitis pigmentosa 17 (autosomal dominant) antibody; RP17 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Carbonic anhydrase 4 protein (75-200AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
  • 基因功能參考文獻(xiàn)：
    1. CA4 is a novel tumour suppressor in Colorectal cancer through the inhibition of the Wnt signalling pathway by targeting the WTAP-WT1-TBL1 axis. CA4 methylation may serve as an independent biomarker for the recurrence of Colorectal cancer . PMID: 26071132
    2. Carbonic anhydrase 4 is lost in papillary thyroid carcinoma but not thyroid nodules PMID: 24880201
    3. Although CA IV has been shown to be active in mediating CO2 and HCO3 (-) transport in many important tissues like kidney and lung, and in isolated cells from brain and muscle, the gene for CA IV appears not to be essential. PMID: 24146379
    4. Coexpression of CAIV with MCT1 and MCT4 resulted in a significant increase in MCT transport activity. PMID: 24338019
    5. membrane-associated CA IV contributes robust catalytic activity intracellularly, and this activity participates in regulating H(+) dynamics in the cytosol PMID: 23297198
    6. Two SNPs of carbonic anhydrase IV, which are responsible for amino acid changes, were found. The frequencies of these SNPs were not significantly different between the caries-free group and the group with caries PMID: 22021688
    7. compared the subcellular localization and post-translational processing of wild-type (WT)- and retinitis pigmentosa 17 mutant-CAIV in three cell types PMID: 20626030
    8. The results suggest that the expression level of carbonic anhydrase IV may be important to maintain retina function in retinitis pigmentosa. PMID: 20450258
    9. renal injury inflicted by expression of human carbonic anhydrase IV folding mutants was markedly enhanced by haploinsufficiency of the endoplasmic reticulum cochaperone p58(IPK). PMID: 20308551
    10. binding by extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger PMID: 11994299
    11. carbonic anhydrase IV binds EC4 of NBC1, and this interaction is essential for full NBC1 activity PMID: 14567693
    12. mutation was found to cosegregate with the retinitis pigmentosa RP17 phenotype in two large families PMID: 15090652
    13. CA inhibitors may have long-term adverse effects on vision. PMID: 15563508
    14. characterized the CA IV expressed in Capan-1 cells PMID: 17409381
    15. A novel mutation has been identified in CA4 that provides further evidence that impaired pH regulation may underlie photoreceptor degeneration in retinitis pigmentosa PMID: 17652713
    16. CAIV p.R14W sequence variant found in one of the patients with Bothnia dystrophy phenotype is benign polymorphism in population of northern Sweden. PMID: 18344446
    17. Apoptosis induced by the CA IV mutants could be prevented, at least partially, by treating the cells with dorzolamide, a CA inhibitor PMID: 19211803

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Retinitis pigmentosa 17 (RP17)
  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Alpha-carbonic anhydrase family
  • 組織特異性：
    Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1375

    OMIM: 114760

    KEGG: hsa:762

    STRING: 9606.ENSP00000300900

    UniGene: Hs.89485



主站蜘蛛池模板： 久久人人爽天天玩人人妻精品 | 日本少妇春药特殊按摩3| 99精品视频九九精品视频| 国产精品无码av天天爽播放器| 孕妇怀孕高潮潮喷视频孕妇| 亚洲伊人色欲综合网无码中文 | 综合 欧美 亚洲日本| 丝袜老师办公室里做好紧好爽 | 久久综合香蕉国产蜜臀av | 免费大片av手机看片不卡| 国产综合久久久久久鬼色| 国产99久久久国产精品～～牛| 东京热人妻无码一区二区av| 永久免费无码网站在线观看个| 大屁股熟女一区二区三区| 少妇人妻互换不带套| 2019最新久久久视频精品| 本道久久综合无码中文字幕| 一本色综合亚洲精品蜜桃冫| 亚洲精品成人无限看| 熟女毛多熟妇人妻在线视频| 亚洲国产精品无码专区影院| 同性男男黄g片免费网站| 日本高清视频www| 无套内射chinesehd熟女| 国产成人精品av| 国产午夜精品无码| 性欧美俄罗斯极品| 丝袜足控一区二区三区| 综合网日日天干夜夜久久| 少妇高潮太爽了在线观看| 免费无码成人av片在线| 色妞ww精品视频7777| 高清无码视频直接看| 日本韩国的免费观看视频| 人人爽人人爽人人片av亚洲| 日韩精品一区二区三区免费视频| 久久精品无码一区二区app| 成人乱码一区二区三区av66| 亚洲第一无码精品立川理惠| 无码区日韩特区永久免费系列 |