在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. C2orf40 Antibody

C2orf40 Antibody

  • 中文名稱：
    C2orf40兔多克隆抗體
  • 貨號：
    CSB-PA285697
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA285697(C2orf40 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA285697(C2orf40 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    C2orf40
  • 別名：
    AUGN_HUMAN antibody; Augurin antibody; C2orf40 antibody; Esophageal cancer-related gene 4 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human C2orf40
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system. ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.
  • 基因功能參考文獻：
    1. we have provided evidence to show that Ecrg4 is constitutively expressed in atria and the conduction systems and is down-regulated in AF. PMID: 28578429
    2. mutations in Pakistani patients with dilated cardiomyopathy rs375563861 (C2orf40), rs143187236 (MYOM3), and rs564181443 (RTKN2) have 3 fold or higher allele frequency in South Asians than in the global populations PMID: 29886034
    3. ECRG4 down-regulates UBE2C expression in esophageal squamous cell carcinoma cells. PMID: 29268240
    4. Results from many studies support the discovery that ECRG4 plays a critical role in the pathogenesis of atrial fibrillation. [review] PMID: 29126922
    5. UBR5 directly binds to the tumor suppressor esophageal cancer-related gene 4, increasing its ubiquitination to reducing the protein stability of ECRG4 to promote colorectal cancer progression. PMID: 28856538
    6. positive and negative regulatory elements controlling ECRG4 expression include a counter regulation between promoter methylation and Sp1 activation. PMID: 28870864
    7. the overexpression of Beclin 1 promoted apoptosis and decreased invasion by upregulating the expression of ECRG4 in A549 lung adenocarcinoma cells. Therefore, the selection of Beclin l as a target for gene therapy represents a more effective method for the treatment of lung cancer. PMID: 27175789
    8. Downregulated ECRG4 is correlated with lymph node metastasis in nasopharyngeal carcinoma PMID: 27119734
    9. The overexpression of ECRG4 inhibited tumorigenesis. PMID: 26762416
    10. ECRG4 may be a tumor suppressor in renal cancer and serve as a prognostic marker PMID: 26276361
    11. low expression or no expression of ECRG4 in esophageal cancer tissues was closely related to the degree of tumor invasion level, TNM staging, lymph node metastasis and recurrence and survival after surgery. PMID: 26823803
    12. loss of ECRG4 protein expression may be involved in tumor progression and may serve as a prognostic biomarker for breast cancer. PMID: 26631111
    13. Overexpression of ECRG4 inhibited laryngeal cancer cell proliferation and induced cancer cell apoptosis. PMID: 26165988
    14. Our data suggest that methylation-mediated suppression of the ECRG4 gene occurs frequently in nasopharyngeal carcinoma PMID: 25707757
    15. Results identify Ecrg4 as a paracrine factor that activates microglia and is chemotactic for monocytes, with potential as an antitumor therapeutic. PMID: 25378632
    16. ECRG4 is present on the surface of human monocytes and granulocytes and its interaction with the innate immunity receptor complex supports a role for cell surface activation of ECRG4 during inflammation PMID: 25511108
    17. The expression of ECRG4 is frequently upregulated in a papillary thyroid carcinoma through the demethylation mechanism of CpG islands in the gene promoter region, and the ECRG4 has a tumor-promoting function through inducing the cell cycle transition PMID: 25326809
    18. ECRG4 is a candidate tumor suppressor gene that might be involved in the proliferation of esophageal squamous cell carcinoma PMID: 23957914
    19. results suggest that C2ORF40 acts as a tumor suppressor gene in breast cancer pathogenesis and progression and is a candidate prognostic marker for this disease PMID: 23770814
    20. overexpression of ECRG4 enhanced the chemosensitivity of gastric cancer SGC-7901 cells to 5-FU through induction of apoptosis. PMID: 23553029
    21. Aberrant DNA methylation of ECRG4 gene is associated with colorectal cancer. PMID: 22901147
    22. Aberrant ECRG4 promoter methylation may be used to monitor early gastric cancer and predict pathological staging. PMID: 22626786
    23. DNA methylation of the ECRG4 promoter causes loss of ECRG4 gene expression in the esophageal squamous cell carcinoma cell line EC9706. PMID: 22325214
    24. kDa Ecrg4 localizes to the cell surface of prostate (PC3) or kidney (HEK) epithelial cells after transfection. PMID: 22526622
    25. Tumor necrosis factor-alpha-induced apoptosis was also suppressed in ECRG4-overexpressing Jurkat cells. PMID: 22411956
    26. ECRG4 is a candidate tumor suppressor gene in breast cancer PMID: 22110708
    27. Augurin would play a constitutive inhibitory function in normal CNS while down regulation of Ecrg4 gene expression in injury, like in cancer, dysinhibits proliferation. PMID: 21935431
    28. Data show that ECRG4 interacts directly with ECRG1 to upregulate p21 protein expression, induce cell cycle G1 phase block and inhibit cancer cells proliferation in ESCC. PMID: 21288367
    29. Loss of ECRG4 is associated with glioma. PMID: 20598162
    30. ECRG4 is silenced via promoter hypermethylation in different types of human cancer cells. PMID: 20017917
    31. Inactivation of ECRG 4 gene by hypermethylation is a frequent molecular event in esophageal squamous cell carcinoma and may be involved in the carcinogenesis of this cancer. PMID: 12800218
    32. Significantly lower expression of esophageal cancer-related gene 4 is associated with esophageal squamous cell carcinoma PMID: 17786363
    33. The restoration of ECRG4 expression in ESCC cells inhibited cell proliferation, colony formation, cell cycle progression and tumor growth in vivo. ECRG4 is a novel candidate tumor suppressor gene in ESCC. PMID: 19521989

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Cytoplasm. Apical cell membrane.
  • 蛋白家族：
    Augurin family
  • 組織特異性：
    Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level).
  • 數據庫鏈接：

    HGNC: 24642

    OMIM: 611752

    KEGG: hsa:84417

    UniGene: Hs.43125



主站蜘蛛池模板： 亚洲欧美在线一区中文字幕| 久久一日本综合色鬼综合色| 欧美成人天天综合在线| 真实国产乱子伦对白在线播放 | 亚洲高清国产拍精品26u| 在线成人爽a毛片免费软件| 国产美女裸体无遮挡免费视频| 亲嘴扒胸摸屁股激烈网站| 国产999精品久久久久久| 亚洲国产午夜精品理论片在线播放| 久久香港三级台湾三级播放| 四虎国产精品一区二区| 双乳奶水饱满少妇呻吟免费看 | 人妻少妇偷人精品视频| 女子spa高潮呻吟抽搐| 无尺码精品产品视频| 国产成人亚洲精品无码电影| 国产按头口爆吞精在线视频| 免费看国产zzzwww色| 亚洲 中文字幕 日韩 无码| 日韩毛片在线视频x| 嫖妓丰满肥熟妇在线精品| 樱花草在线社区www日本影院| 亚洲日本精品国产一区vr| 777米奇色狠狠888俺也去乱| 曰韩内射六十七十老熟女影视| 国产精品成人免费一区久久羞羞| 国产自愉自愉免费精品七区| 另类亚洲综合区图片小说区| 水蜜桃av导航| 精品久久久无码人妻字幂| 无码人妻精品一区二区三| 在线播放免费人成毛片试看| 亚洲日韩国产中文其他| 国产成人精品无码免费看| 极品熟妇大蝴蝶20p| 中国性少妇内射xxxx狠干| 国产激情综合在线看| 欧美性猛交xxxx乱大交蜜桃| 日韩va中文字幕无码电影| 日韩理论午夜无码|