在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

C1R Antibody

  • 中文名稱:
    C1R兔多克隆抗體
  • 貨號:
    CSB-PA003655LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, Rat heart tissue
      All lanes: C1R antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 81 kDa
      Observed band size: 81 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA003655LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA003655LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) C1R Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    C1 R antibody; C1R antibody; C1R_HUMAN antibody; Complement C1r antibody; Complement C1r subcomponent antibody; Complement C1r subcomponent light chain antibody; Complement C1r subcomponent precursor antibody; Complement component 1 r subcomponent antibody; Complement component 1 subcomponent r antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Complement C1r subcomponent protein (65-192AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,C1R Antibody (CSB-PA003655LA01HU),的標記方式是Non-conjugated。對于C1R Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA003655LB01HU C1R Antibody, HRP conjugated ELISA
    FITC CSB-PA003655LC01HU C1R Antibody, FITC conjugated
    Biotin CSB-PA003655LD01HU C1R Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
  • 基因功能參考文獻:
    1. The serine protease domains of C1r and C1s are at the periphery of the C1r2s2 tetramer both when alone or within the nonactivated C1 complex. The C1 complex adopts a conformation incompatible with intramolecular activation of C1. Instead, intermolecular proteolytic activation between neighboring C1 complexes bound to a complement-activating surface occurs. Many structurally unrelated molecular patterns can activate C1. PMID: 28104818
    2. We identified a novel, homozygous, loss-of-function mutation (p.Pro445Leufs*11) in the C1R gene. Using the Sanger method of DNA sequencing in 14 family members, we confirmed the presence of the mutation in 4 patients with early-onset systemic lupus erythematosus and in an asymptomatic 9-year-old girl. Complement levels were low in sera from patients with truncated C1r protein. PMID: 28544690
    3. Periodontal Ehlers-Danlos Syndrome in at least the great majority of cases results from specific classes of heterozygous mutations in C1R and C1S. PMID: 27745832
    4. We confirmed increased levels of C1R and VTN in sera from patients with Joint hypermobility syndrome by western blot analyses PMID: 26709396
    5. C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin and nucleophosmin 1. T PMID: 26231209
    6. C1r specificity is well suited to its cleavage targets and that efficient cleavage of C1s is achieved through both active site and exosite contributions. PMID: 23589288
    7. a structural rearrangement as a switch between functional states of human C1r PMID: 20970424
    8. These results provide further structural insights into the architecture of the C1 complex, and the interactions between C1r and C1s. PMID: 20592021
    9. The modular C1r protein is the first protease activated in the classical complement pathway, a key component of innate immunity. PMID: 20796027
    10. Detailed mapping of C1q post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
    11. Using a recombinant CUB2-CCP1 domain pair and the individual CCP1 module, we showed that binding of Ca(2+) induces the folding of the CUB2 domain and stabilizes its structure. PMID: 20178990
    12. These findings show no evidence for association between C1r codon 135 polymorphism and Alzheimer's Disease in our population. PMID: 12499050
    13. Six common and rare alleles, C1R*1, C1R*2, C1R*5, C1R*8, C1R*9, and C1R*13, were characterized by five mutations at amino acid positions 114, 135, 146, 167 and 244, in exons 4, 5 and 7 where the PMID: 12914573
    14. The activated CCP1-CCP2-SP fragment makes up a dimer in a head-to-tail fashion similarly to the previously characterized zymogen. PMID: 17996945
    15. The catalytic properties of C1r, the protease that mediates activation of the C1 complex of complement, are mediated by its C-terminal region, comprising two complement control protein (CCP) modules followed by a serine protease (SP) domain PMID: 11445589

    顯示更多

    收起更多

  • 相關疾病:
    Ehlers-Danlos syndrome, periodontal type, 1 (EDSPD1)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Peptidase S1 family
  • 數據庫鏈接:

    HGNC: 1246

    OMIM: 130080

    KEGG: hsa:715

    UniGene: Hs.524224



主站蜘蛛池模板: 风韵丰满熟妇啪啪区老熟熟女| 亚洲高清国产拍精品闺蜜合租| 色欧美片视频在线观看| 亚洲精品无码久久久久久| 亚洲最大成人一区久久久| 精品免费国产一区二区| 国产精品亚洲专区无码破解版| 最近更新中文字幕| 久久久亚洲欧洲日产国码606| 少妇性荡欲视频| 日韩国产精品无码一区二区三区| 日产精品中文一区二区三区 | 午夜福利伦伦电影理论片在线观看| 亚洲国产精品久久久久秋霞影院 | 日韩中文字幕免费视频| 日日av色欲香天天综合网| 国产v亚洲v天堂a无码99| 亚洲性无码av在线dvd| 97碰碰碰人妻无码视频| 欧美性猛交xxxx富婆| aaa欧美色吧激情视频| 亚洲欧洲精品成人久久曰影片| 东北少妇不带套对白| 天堂在线资源中文在线8| 国产男女免费完整视频在线| 夜夜爽日日澡人人添| 人妻无码一区二区三区 tv| 亚洲美女高清aⅴ视频免费| 最近最新中文字幕高清免费| 亚洲精品自在在线观看| 在线成人a毛片免费播放| 牲高潮99爽久久久久777| 亚洲色丰满少妇高潮18p| 国内揄拍国产精品人妻门事件 | 日本午夜免费啪视频在线| 欧美性猛交xxxxx按摩欧美| 国产精品久久久久久亚洲色| 国产精品成人av在线观看春天| 国产精品亚洲w码日韩中文 | 国产成人精品视频ⅴa片软件竹菊| 亚洲中文字幕无码av永久|