在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

C1R Antibody

  • 中文名稱:
    C1R兔多克隆抗體
  • 貨號:
    CSB-PA003655LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, Rat heart tissue
      All lanes: C1R antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 81 kDa
      Observed band size: 81 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA003655LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA003655LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) C1R Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    C1 R antibody; C1R antibody; C1R_HUMAN antibody; Complement C1r antibody; Complement C1r subcomponent antibody; Complement C1r subcomponent light chain antibody; Complement C1r subcomponent precursor antibody; Complement component 1 r subcomponent antibody; Complement component 1 subcomponent r antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Complement C1r subcomponent protein (65-192AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,C1R Antibody (CSB-PA003655LA01HU),的標記方式是Non-conjugated。對于C1R Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA003655LB01HU C1R Antibody, HRP conjugated ELISA
    FITC CSB-PA003655LC01HU C1R Antibody, FITC conjugated
    Biotin CSB-PA003655LD01HU C1R Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
  • 基因功能參考文獻:
    1. The serine protease domains of C1r and C1s are at the periphery of the C1r2s2 tetramer both when alone or within the nonactivated C1 complex. The C1 complex adopts a conformation incompatible with intramolecular activation of C1. Instead, intermolecular proteolytic activation between neighboring C1 complexes bound to a complement-activating surface occurs. Many structurally unrelated molecular patterns can activate C1. PMID: 28104818
    2. We identified a novel, homozygous, loss-of-function mutation (p.Pro445Leufs*11) in the C1R gene. Using the Sanger method of DNA sequencing in 14 family members, we confirmed the presence of the mutation in 4 patients with early-onset systemic lupus erythematosus and in an asymptomatic 9-year-old girl. Complement levels were low in sera from patients with truncated C1r protein. PMID: 28544690
    3. Periodontal Ehlers-Danlos Syndrome in at least the great majority of cases results from specific classes of heterozygous mutations in C1R and C1S. PMID: 27745832
    4. We confirmed increased levels of C1R and VTN in sera from patients with Joint hypermobility syndrome by western blot analyses PMID: 26709396
    5. C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin and nucleophosmin 1. T PMID: 26231209
    6. C1r specificity is well suited to its cleavage targets and that efficient cleavage of C1s is achieved through both active site and exosite contributions. PMID: 23589288
    7. a structural rearrangement as a switch between functional states of human C1r PMID: 20970424
    8. These results provide further structural insights into the architecture of the C1 complex, and the interactions between C1r and C1s. PMID: 20592021
    9. The modular C1r protein is the first protease activated in the classical complement pathway, a key component of innate immunity. PMID: 20796027
    10. Detailed mapping of C1q post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
    11. Using a recombinant CUB2-CCP1 domain pair and the individual CCP1 module, we showed that binding of Ca(2+) induces the folding of the CUB2 domain and stabilizes its structure. PMID: 20178990
    12. These findings show no evidence for association between C1r codon 135 polymorphism and Alzheimer's Disease in our population. PMID: 12499050
    13. Six common and rare alleles, C1R*1, C1R*2, C1R*5, C1R*8, C1R*9, and C1R*13, were characterized by five mutations at amino acid positions 114, 135, 146, 167 and 244, in exons 4, 5 and 7 where the PMID: 12914573
    14. The activated CCP1-CCP2-SP fragment makes up a dimer in a head-to-tail fashion similarly to the previously characterized zymogen. PMID: 17996945
    15. The catalytic properties of C1r, the protease that mediates activation of the C1 complex of complement, are mediated by its C-terminal region, comprising two complement control protein (CCP) modules followed by a serine protease (SP) domain PMID: 11445589

    顯示更多

    收起更多

  • 相關疾病:
    Ehlers-Danlos syndrome, periodontal type, 1 (EDSPD1)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Peptidase S1 family
  • 數據庫鏈接:

    HGNC: 1246

    OMIM: 130080

    KEGG: hsa:715

    UniGene: Hs.524224



主站蜘蛛池模板: 亚洲日本中文字幕乱码在线| 中文字幕无码人妻少妇免费| 2021精品国夜夜天天拍拍| 亚洲精品成人福利网站| 久久久无码精品亚洲日韩啪啪网站 | 国内揄拍国内精品对白| 久久国产免费观看精品a片| 国产精品福利视频导航| 无遮无挡爽爽免费毛片| 国产真实野战在线视频| 猫咪免费人成网站在线观看| 影音先锋每日av色资源站| 亚洲国产成人一区二区在线| 国产无套护士在线观看| 四虎影视在线永久免费观看| 水蜜桃色314在线观看| 中文字幕人妻熟女人妻洋洋| 亚洲国产日韩在线人成蜜芽| 极品少妇伦理一区二区| 日韩经典午夜福利发布| 暖暖 免费 高清 日本 在线| 色综合天天综合欧美综合| 国产精品一区二区无线| 亚洲第一综合天堂另类专| 天堂va欧美va亚洲va好看va| 精品人成视频免费国产| 黑森林福利视频导航| 日韩a无v码在线播放| 国产成人高清亚洲一区妲妃| 精品国产av一二三四区| 欧美性猛交xxxx乱大交丰满| 亚洲乱码中文论理电影| 最新日韩精品中文字幕| 小sao货水好多真紧h无码视频 | 亚洲一区二区三区播放| 欧美性生交大片免费看| 免费两性的视频网站 | 国精产品48x国精产品| 欧美xxxxx高潮喷水| 国产女人与公拘交在线播放| 亚洲精品国偷自产在线99人热|