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  4. C1QTNF9 Antibody

C1QTNF9 Antibody

  • 中文名稱：
    C1QTNF9兔多克隆抗體
  • 貨號：
    CSB-PA003654PA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA003654PA01HU diluted at 1:100 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) C1QTNF9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    C1QTNF9
  • 別名：
    Complement C1q and tumor necrosis factor-related protein 9A (Complement C1q and tumor necrosis factor-related protein 9), C1QTNF9, C1QTNF9A
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Complement C1q and tumor necrosis factor-related protein 9A protein (58-72aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，C1QTNF9 Antibody (CSB-PA003654PA01HU)，的標(biāo)記方式是Non-conjugated。對于C1QTNF9 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA003654PB01HU C1QTNF9 Antibody, HRP conjugated ELISA
    FITC CSB-PA003654PC01HU C1QTNF9 Antibody, FITC conjugated
    Biotin CSB-PA003654PD01HU C1QTNF9 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.
  • 基因功能參考文獻(xiàn)：
    1. suggesting the protective potentials of C1q tumour necrosis factor-related protein 9 in the progression of peripheral arterial disease in human type 2 diabetes mellitus PMID: 29543038
    2. Authors demonstrate that CTRP9 regulates growth, differentiation, and apoptosis of HaCaT human keratinocytes. We found that CTRP9 augmented expression of transforming growth factor beta 1 (TGFbeta1) by transcription factor activator protein 1 (AP-1) binding activity and phosphorylation of p38 in a dose-dependent manner. PMID: 29145717
    3. CTRP9 inhibits the cholesterol-induced Vascular smooth muscle cell phenotype switch and cell dysfunction by activating PRKAA1. PMID: 28524645
    4. results revealed increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests a compensatory response to insulin resistance, inflammatory milieu and endothelial dysfunction; however, more studies are needed to confirm this PMID: 29381773
    5. CTRP9 levels are elevated in obesity and significantly decrease following weight loss surgery. PMID: 26982010
    6. Plasma CTRP9 levels are associated with atherosclerosis in diabetic patients without CKD, independently of obesity, adiponectin, and traditional cardiovascular risk factors PMID: 28070523
    7. The up-regulation of CTRP9 during hypertrophic heart disease facilitates maladaptive cardiac remodeling and left ventricular dysfunction. PMID: 27821723
    8. Results demonstrate that CTRP9 alleviates hepatic steatosis through relief of endoplasmic reticulum stress via the AMPK-mediated induction of autophagy. PMID: 26419929
    9. Study demonstrates that CTRP9 attenuates cytokine-induced vascular inflammation in endothelial cells mediated by AMPK activation. PMID: 26523509
    10. Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients. Serum CTRP9 is an independent protective factor of CAD PMID: 26457306
    11. Serum CTRP9 concentration was significantly and positively associated with arterial stiffness in patients with type 2 diabetes PMID: 25105737
    12. Serum CTRP9 concentrations were positively associated with favorable glucose or metabolic phenotypes and absence of metabolic syndrome, independent of serum total adiponectin concentrations. PMID: 24357853

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  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Expressed predominantly in adipose tissue.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28732

    OMIM: 614285

    KEGG: hsa:338872

    STRING: 9606.ENSP00000333737

    UniGene: Hs.362854



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