在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Botulinum neurotoxin type E Antibody, HRP conjugated

Rare Species
  • 中文名稱:
    Botulinum neurotoxin type E兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA327013LB01DUK
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Clostridium butyricum N/A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    N/A
  • 別名:
    Botulinum neurotoxin type E antibody; BoNT/E antibody; Bontoxilysin-E) [Cleaved into: Botulinum neurotoxin E light chain antibody; LC antibody; EC 3.4.24.69); Botulinum neurotoxin E heavy chain antibody; HC)] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Clostridium butyricum
  • 免疫原:
    Recombinant Clostridium butyricum Botulinum neurotoxin type E protein (2-422AA)
  • 免疫原種屬:
    Clostridium butyricum
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin E which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter release.; Has proteolytic activity. After translocation into the eukaryotic host cytosol, LC hydrolyzes the '180-Arg-|-Ile-181' bond in SNAP25, blocking neurotransmitter release.; Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of light chain (LC) into host cytosol. Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD). The RBD is responsible for the adherence of the toxin to the cell surface. It simultaneously recognizes 2 coreceptors; host polysialated gangliosides and the receptor proteins SV2A and SV2B in close proximity on host synaptic vesicles. Interaction with SV2 proteins requires SV2 glycosylation. The N-terminus of the TD wraps an extended belt around the perimeter of the LC, protecting Zn(2+) in the active site; it may also prevent premature LC dissociation from the translocation channel and protect toxin prior to translocation. The TD inserts into synaptic vesicle membrane to allow translocation into the host cytosol. Binds ganglioside GD1a in vitro.
  • 亞細胞定位:
    [Botulinum neurotoxin type E]: Secreted.; [Botulinum neurotoxin E light chain]: Secreted. Host cytoplasm, host cytosol.; [Botulinum neurotoxin E heavy chain]: Secreted. Host cell junction, host synapse, host presynaptic cell membrane. Host cytoplasmic vesicle, host secretory vesicle, host synaptic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Peptidase M27 family


主站蜘蛛池模板: 熟妇的奶头又大又长奶水视频| 精品无码久久久久久久动漫| 真实国产精品vr专区| 亚洲无线码在线一区观看| 老头把我添高潮了a片| 无码国模大尺度视频在线观看| 欧美亚洲一区二区三区| 国产真实老熟女无套内射| 国产欧美日韩亚洲18禁在线| 国产高清不卡无码视频| 国产精品vr专区| 成在线人视频免费视频| 国产剧情无码播放在线看| 影音先锋人妻每日资源站| 欧美午夜精品久久久久久浪潮| 亚洲国产精品嫩草影院| 国产在线视频主播区| 色婷婷狠狠97成为人免费| 日韩新无码精品毛片| 女子spa高潮呻吟抽搐| 久久国产成人精品av| 女人被狂躁高潮啊的视频在线看| 欧洲美熟女乱又伦免费视频| 蜜臀av午夜一区二区三区| 国产极品视觉盛宴| 婷婷丁香五月缴情视频| 97久久国产成人免费网站| av狠狠色超碰丁香婷婷综合久久| 日韩成人无码中文字幕| 国产精品区免费视频| 蜜桃av麻豆av果冻传媒| 国产成+人欧美+综合在线观看| 国产成人av激情在线播放| 精品无码久久久久国产手机版| 国产l精品国产亚洲区久久| .精品久久久麻豆国产精品 | 强 暴 疼 哭 处 女 身子视频| 亚洲国产美国国产综合一区| 国模大尺度啪啪| 5d肉蒲团之性战奶水| 国产乱人伦真实精品视频|