在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

BUB3 Antibody

  • 中文名稱:
    BUB3兔多克隆抗體
  • 貨號:
    CSB-PA001070
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using Bub3 Polyclonal Antibody
    • Western Blot analysis of A549 cells using Bub3 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Aa2-050 antibody; AU019800 antibody; AU021329 antibody; AU043350 antibody; AW146323 antibody; BUB 3 antibody; BUB 3L antibody; BUB3 (budding uninhibited by benzimidazoles 3; yeast) homolog antibody; bub3 antibody; BUB3 budding uninhibited by benzimidazoles 3 homolog antibody; BUB3 mitotic checkpoint protein antibody; BUB3_HUMAN antibody; BUB3L antibody; Budding uninhibited by benomyl antibody; Budding uninhibited by benzimidazoles 3 antibody; Budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) antibody; Budding uninhibited by benzimidazoles 3 homolog (yeast) antibody; Budding uninhibited by benzimidazoles 3 homolog antibody; Budding uninhibited by benzimidazoles 3; S. cerevisiae; homolog of antibody; C78067 antibody; hBUB3 antibody; Mitotic checkpoint component antibody; Mitotic checkpoint protein bub3 antibody; OTTHUMP00000020679 antibody; OTTHUMP00000020680 antibody; WD repeat type I transmembrane protein A72.5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human Bub3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
  • 基因功能參考文獻:
    1. Small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the spindle assembly checkpoint signaling cascade. PMID: 28943088
    2. The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 and Bub3, for which the BubR1 Gle2 binding sequence motif is essential. PMID: 27030009
    3. We show that kinetochore recruitment of BUBR1 and BUB3 by BUB1 is dispensable for SAC activation PMID: 26148513
    4. a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments PMID: 26526612
    5. the mechanisms of BUB3 in mitotic checkpoint signaling PMID: 25814666
    6. Data show sequential multisite regulation of the microtubule-associated protein KNL1-kinase-adaptor complex BUB1/BUB3 interaction. PMID: 25661489
    7. Data indicate that cell cycle protein Bub3-mediated kinetochore recruitment of BubR1 kinase enhances mitotic checkpoint signaling. PMID: 25246557
    8. Results suggest that these USP7-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC) component Bub3. PMID: 25003721
    9. Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC kinase Bub1. Crucially, they also cause a checkpoint defect, showing that recognition of phosphorylated targets by Bub3 is required for checkpoint signaling PMID: 24066227
    10. Results showed that neither variants in BUB3 nor variants in MAD2L1 caused any significant effect on the risk of breast cancer PMID: 24711138
    11. Mutations in BUB1 and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age. PMID: 23747338
    12. These results indicate that Bub3 and Cdc20 play additional roles in the integration of cell cycle arrest as transcriptional repressors. PMID: 15388328
    13. Allelic loss at 10q26 in osteosarcoma is reported in the region of BUB3. PMID: 15796961
    14. subpopulation of dynein, containing the DYNLT3 light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole PMID: 17289665
    15. Using RNA interference and high-resolution microscopy, we analyzed kinetochore-microtubule attachments in Bub3-depleted cells and compared them to those in Bub1- or BubR1-depleted cells. PMID: 18199686
    16. Results suggest a novel molecular mechanism leading to aneuploidy involving interference of TAp73alpha with Bub1 and Bub3 resulting in an altered mitotic checkpoint. PMID: 19182530

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome, centromere, kinetochore.
  • 蛋白家族:
    WD repeat BUB3 family
  • 數據庫鏈接:

    HGNC: 1151

    OMIM: 603719

    KEGG: hsa:9184

    STRING: 9606.ENSP00000357858

    UniGene: Hs.418533



主站蜘蛛池模板: 真人做人试看60分钟免费视频| 国产欧美日韩综合精品一区二区| 波多野结衣av无码| 国产成人精品午夜福利在线播放| 免费看女人与公拘交酡过程| 亚洲伊人成综合网2222| 精品久久久久久无码人妻热| 精品无码av无码专区| 亚洲综合一区国产精品| 亚洲中文字幕无码av在线| 久久精品中文字幕无码绿巨人| 国产精品卡1卡2卡三卡四| 亚洲精品久久久无码大桥未久| 亚洲伊人成综合网| 久久无码人妻丰满熟妇区毛片| 久青草国产97香蕉在线影院| 人妻少妇无码中文幕久久| 国产av无码国产av毛片| 欧美午夜精品久久久久久浪潮| 亚洲精品一区二区三区麻豆| 亚洲欧洲美洲在线观看| 亚洲精品久久久久久久蜜桃| 色狠狠av一区二区三区| 亚洲一区二区三区无码av| 狠狠色狠狠色综合网| 久久人妻无码一区二区| 色老99久久九九爱精品| 成人伊人青草久久综合网| 国产精品水嫩水嫩| 欧美人与动牲交a欧美| 国产1卡二卡3卡四卡乱码视频| 日韩国产人妻一区二区三区| 国产午夜精品理论片| 欧美人妻体内射射| 亚洲精品成人网站在线观看| 亚洲熟熟妇xxxx| 成人免费午夜无码视频在线播放| 国产亚洲精品综合一区| 国产成人无码aⅴ片在线观看| 99热99这里只有高清国产| 西西人体做爰大胆性自慰|