在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

BUB3 Antibody

  • 中文名稱:
    BUB3兔多克隆抗體
  • 貨號:
    CSB-PA001070
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using Bub3 Polyclonal Antibody
    • Western Blot analysis of A549 cells using Bub3 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Aa2-050 antibody; AU019800 antibody; AU021329 antibody; AU043350 antibody; AW146323 antibody; BUB 3 antibody; BUB 3L antibody; BUB3 (budding uninhibited by benzimidazoles 3; yeast) homolog antibody; bub3 antibody; BUB3 budding uninhibited by benzimidazoles 3 homolog antibody; BUB3 mitotic checkpoint protein antibody; BUB3_HUMAN antibody; BUB3L antibody; Budding uninhibited by benomyl antibody; Budding uninhibited by benzimidazoles 3 antibody; Budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) antibody; Budding uninhibited by benzimidazoles 3 homolog (yeast) antibody; Budding uninhibited by benzimidazoles 3 homolog antibody; Budding uninhibited by benzimidazoles 3; S. cerevisiae; homolog of antibody; C78067 antibody; hBUB3 antibody; Mitotic checkpoint component antibody; Mitotic checkpoint protein bub3 antibody; OTTHUMP00000020679 antibody; OTTHUMP00000020680 antibody; WD repeat type I transmembrane protein A72.5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human Bub3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
  • 基因功能參考文獻:
    1. Small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the spindle assembly checkpoint signaling cascade. PMID: 28943088
    2. The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 and Bub3, for which the BubR1 Gle2 binding sequence motif is essential. PMID: 27030009
    3. We show that kinetochore recruitment of BUBR1 and BUB3 by BUB1 is dispensable for SAC activation PMID: 26148513
    4. a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments PMID: 26526612
    5. the mechanisms of BUB3 in mitotic checkpoint signaling PMID: 25814666
    6. Data show sequential multisite regulation of the microtubule-associated protein KNL1-kinase-adaptor complex BUB1/BUB3 interaction. PMID: 25661489
    7. Data indicate that cell cycle protein Bub3-mediated kinetochore recruitment of BubR1 kinase enhances mitotic checkpoint signaling. PMID: 25246557
    8. Results suggest that these USP7-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC) component Bub3. PMID: 25003721
    9. Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC kinase Bub1. Crucially, they also cause a checkpoint defect, showing that recognition of phosphorylated targets by Bub3 is required for checkpoint signaling PMID: 24066227
    10. Results showed that neither variants in BUB3 nor variants in MAD2L1 caused any significant effect on the risk of breast cancer PMID: 24711138
    11. Mutations in BUB1 and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age. PMID: 23747338
    12. These results indicate that Bub3 and Cdc20 play additional roles in the integration of cell cycle arrest as transcriptional repressors. PMID: 15388328
    13. Allelic loss at 10q26 in osteosarcoma is reported in the region of BUB3. PMID: 15796961
    14. subpopulation of dynein, containing the DYNLT3 light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole PMID: 17289665
    15. Using RNA interference and high-resolution microscopy, we analyzed kinetochore-microtubule attachments in Bub3-depleted cells and compared them to those in Bub1- or BubR1-depleted cells. PMID: 18199686
    16. Results suggest a novel molecular mechanism leading to aneuploidy involving interference of TAp73alpha with Bub1 and Bub3 resulting in an altered mitotic checkpoint. PMID: 19182530

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome, centromere, kinetochore.
  • 蛋白家族:
    WD repeat BUB3 family
  • 數據庫鏈接:

    HGNC: 1151

    OMIM: 603719

    KEGG: hsa:9184

    STRING: 9606.ENSP00000357858

    UniGene: Hs.418533



主站蜘蛛池模板: 777米奇影视第四色| 国产亚洲精品久久久久蜜臀| 亚洲免费人成在线视频观看| 亚洲色无码国产精品网站可下载| 奇米777狠狠色噜噜狠狠狠| 久久人人97超碰国产公开| 免费久久人人爽人人爽av| 久久久天堂国产精品女人| 中文字幕精品视频在线看免费 | 免费很黄无遮挡的视频| 日韩夜夜高潮夜夜爽无码| 少妇性l交大片毛多| 亚洲乱色伦图片区小说| 免费国产在线精品一区二区三区| 少妇系列之白嫩人妻| 熟妇人妻无码xxx视频| 少妇性荡欲视频| 在线观看午夜亚洲一区| 看曰本女人大战黑人视频| 久久婷婷五月综合色首页| 国产老太睡小伙子视频| 亚洲国产精品第一区二区 | 国产精品老汉av| 人妻性奴波多野结衣无码| 无码毛片aaa在线| 精品夜夜澡人妻无码av| 久久久久久无码日韩欧美| av中文无码韩国亚洲色偷偷| 无码人妻熟妇av又粗又大| 成人区精品一区二区不卡| 亚洲精品久久国产高清小说| 午夜福利电影| 伊人久久综合成人网| 极品无码国模国产在线观看| 少妇人妻无码专区视频| 新狼窝色av性久久久久久| 国产性―交―乱―色―情人| 日本少妇自慰免费完整版| 精品国产乱码久久久久久免费| 在线播放十八禁视频无遮挡| 成人国产精品秘片多多|