在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BRAT1 Antibody

BRAT1 Antibody

  • 中文名稱：
    BRAT1兔多克隆抗體
  • 貨號：
    CSB-PA757659LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, PC3 whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate, A549 whole cell lysate
      All lanes: BRAT1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 89, 31, 32 kDa
      Observed band size: 89 kDa
    • IHC image of CSB-PA757659LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA757659LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) BRAT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    BRAT1
  • 別名：
    BAAT 1 antibody; BAAT1 antibody; BRAT 1 antibody; brat1 antibody; BRAT1_HUMAN antibody; BRCA1-associated ATM activator 1 antibody; BRCA1-associated protein required for ATM activation protein 1 antibody; BRCA1-associated protein required for ATM activation-1 antibody; C7orf27 antibody; chromosome 7 open reading frame 27 antibody; HEAT repeat containing protein C7orf27 antibody; MGC22916 antibody; RMFSL antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human BRCA1-associated ATM activator 1 protein (603-821AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，BRAT1 Antibody (CSB-PA757659LA01HU)，的標記方式是Non-conjugated。對于BRAT1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA757659LB01HU BRAT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA757659LC01HU BRAT1 Antibody, FITC conjugated
    Biotin CSB-PA757659LD01HU BRAT1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors.
  • 基因功能參考文獻：
    1. Biallelic sequence variants in BRAT1 have been reported to cause a variety of ocular and systemic manifestations, but to our knowledge, this is the first report of inner retinal dysfunction manifest as selective loss of full-field ERG scotopic and photopic b-wave amplitudes. PMID: 28635423
    2. compared with RMFSL, BRAT1 mutations can result in both moderately severe presentations evident by later-onset epilepsy and survival past infancy, as well as milder presentations that include intellectual disability, ataxia/dyspraxia, and cerebellar atrophy. PMID: 27282546
    3. our data expand the clinical symptoms and demonstrate variability in the natural clinical course of BRAT1-associated phenotypes. Patients with early onset seizures, postnatal microcephaly, feeding problems, and muscular hypertonia or contractures should hence be screened for BRAT1 mutations. PMID: 27282648
    4. we report two affected siblings with compound heterozygous truncating mutations in BRAT1 and intra-familial phenotypic heterogeneity, with a less severe disease course in the female sibling. This phenotypic variability should be taken into account when treating patients with BRAT1-associated neurodegenerative disease. PMID: 27480663
    5. We conclude that BRAT1 should be added to the growing list of genes related to early-onset severe encephalopathy with epilepsy. PMID: 26535877
    6. Our results further support that mutations of BRAT1 could lead to epileptic encephalopathy. PMID: 25319849
    7. Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 into the nucleus. PMID: 25631046
    8. Findings suggest novel roles of BRAT1 in cell proliferation and mitochondrial functions. PMID: 25070371
    9. Data on crystal structure of BRCA1 binding with phosphopeptides suggest that C-terminal domain of BRCA1 interacts with BAAT1 and ATRIP with preferences for specific side chains; in BAAT1, phospho-Ser269 and Phe272 are the main interacting residues. PMID: 24073851
    10. Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. PMID: 22279524

    顯示更多

    收起更多

  • 相關疾病：
    Rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL)
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 21701

    OMIM: 614498

    KEGG: hsa:221927

    STRING: 9606.ENSP00000339637

    UniGene: Hs.520623



主站蜘蛛池模板： 天天做天天大爽天天爱| 久久天堂av综合合色蜜桃网| 国产精品成人一区二区不卡| 国产精品无需播放器在线观看| 超清无码波多野吉衣中文| 亚洲人成日韩中文字幕无卡| 拍真实国产伦偷精品| 久久综合九色综合欧美98 | 熟女内射v888av| 爆乳熟妇一区二区三区| 亚洲精品国产福利一区二区| 午夜肉伦伦影院| 欧美人与动性xxxxx交性| 午夜免费男女aaaa片| 性色av免费观看| 寂寞骚妇被后入式爆草抓爆| 国产欧美在线一区二区三| 色综合天天综合欧美综合| 丰满岳乱妇久久久| 乱人伦人妻精品一区二区| 精久国产av一区二区三区孕妇| 亚洲精品国产av天美传媒| 丝袜高跟麻麻浓精受孕人妻| 精品久久久久久777米琪桃花| 亚洲人成网77777亚洲色| 久久中文字幕无码专区| 国产成人无码av在线播放dvd| 乱人伦中文视频在线| 久久久国产99久久国产久麻豆| 欧美人与动牲交免费观看网| 99国产精品久久久久久久成人热| 国产精品自在线拍国产电影 | 青青青草国产线观| 久久www成人影院| 亚洲伊人成综合网| 老太脱裤让老头玩ⅹxxxx | 欧美性受xxxxzooz乱毛| 成人小说亚洲一区二区三区| 丰满岳跪趴高撅肥臀尤物在线观看 | 欧美牲交a欧美牲交aⅴ另类| 亚洲精品一区二区精华液|