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  4. BNIP2 Antibody

BNIP2 Antibody

  • 中文名稱：
    BNIP2兔多克隆抗體
  • 貨號：
    CSB-PA050117
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    BNIP2
  • 別名：
    BCL2/adenovirus E1B 19 kDa protein interacting protein 2 antibody; BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 antibody; BCL2/adenovirus E1B 19kDa interacting protein 2 antibody; BNIP 2 antibody; Bnip2 antibody; BNIP2_HUMAN antibody; NIP2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human BNIP-2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IF, FCM, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    FC 1:200-1:400
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
  • 基因功能參考文獻：
    1. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. PMID: 25472445
    2. BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain. PMID: 25378581
    3. Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2. PMID: 21130087
    4. Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing. PMID: 20704564
    5. Transfection of the bnip2 cDNA in neuroblastoma cell line results in massive cell death counteracted by Bcl-2 overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells PMID: 11744098
    6. BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1 PMID: 12944407
    7. BNIP-2 in vivo induces cell dynamics by recruiting Cdc42 PMID: 15652341
    8. Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. PMID: 17961507

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.
  • 數據庫鏈接：

    HGNC: 1083

    OMIM: 603292

    KEGG: hsa:663

    STRING: 9606.ENSP00000267859

    UniGene: Hs.592515



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